DRSC/TRiP Functional Genomics Resources

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Protein Alignment kirre and Kirrel2

DIOPT Version :9

Sequence 1:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_038957463.1 Gene:Kirrel2 / 100359836 RGDID:1308456 Length:711 Species:Rattus norvegicus


Alignment Length:704 Identity:188/704 - (26%)
Similarity:294/704 - (41%) Gaps:96/704 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 HFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLD 147
            ||..:|:|...::|....|||.:....|.:|||||...||..|:|.|:.||.:.|:...|...|.
  Rat    33 HFLQQPEDMVVLLGQEARLPCALGAYRGLVQWTKDGLALGGERDLPGWSRYWISGNSASGQHDLH 97

  Fly   148 IYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQ 212
            |.|:.|:|:|.|:||.     .:.|:|||.|:|.|:||||||::..|..:.........|.|.|:
  Rat    98 IKPVELEDEASYECQA-----SQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSR 157

  Fly   213 G-GKPAAEITWI-DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTAD 275
            | .:||.|:.|. ||   :...|..:.:..|.|....|..:.|.|.|..:....|..|:|::.|.
  Rat   158 GDARPAPELLWFRDG---IRLDGTSFHQITLRDKATGTVENTLFLTPSSQDDGATLICRARSQAL 219

  Fly   276 RTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGD 340
            .|.|...:.|.::|.|.|.:|.     ......||.:|...|||.|.|....|||......:.|.
  Rat   220 PTGRDTAVTLSLQYPPMVTLSA-----EPQTAQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGA 279

  Fly   341 FTTKMIIHNVSRQYHDAI-----VKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVS 400
            ...::.:      ..||.     |.|||.||||.:.:|..|::.:||:.:.:|..|..|:|...|
  Rat   280 RGPRLEV------VADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKPVSVDVGKDAS 338

  Fly   401 MRCDVAGNPEPEIEWISENSDQVVGVAAELKL-KVSSETAGRYFCKA------VVNGFPEIGAEA 458
            ..|...|||.|.|.|......||:.....|:| .|:.|.||.|.|:|      |..|    .|:|
  Rat   339 FSCVWRGNPLPRISWTRLGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGVGGG----TAQA 399

  Fly   459 TLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHL 523
            .|.|...|::|:.......:.|..::.|:.|:.|..:.::||::...:...|...  ::.|....
  Rat   400 RLTVNAPPVVTALHPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSLGR--FLVEAFPA 462

  Fly   524 PE-------GVRAALIIRDSKATHFGK-YNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFC 580
            ||       |:.:.|.|..::.:.|.. :||:..|..|...:.|.|.|. ..:|.:.:|.|:...
  Rat   463 PEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRR-DLLPTVRLVAGAASA 526

  Fly   581 VAIILMIVM-IIIVYRKRRSRKKPMPADVIPEASRG------------------------GDKLN 620
            ...:.|::. :::...:..|..|......||.:|.|                        .|.:.
  Rat   527 ATSLFMVITGVVLCCWRHGSLSKQKNLVRIPGSSEGSSAHGPEEETGSSEDRGPIVHTDHNDLVL 591

  Fly   621 ELKSELRSKAYDVEYSEAGGDGLAINLTQSP-----MPDVQMKGATLGVP----------LAGPV 670
            |....|.:|.....|.:..|..::::|.::|     :|.....|.. |.|          |..|.
  Rat   592 EENEALETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPPSPMGLP-GTPTYYDFKPHLDLVPPC 655

  Fly   671 KFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQANGYAHYFEYALDYSPP 724
            :.....:|      |....|.:...|..:....|.|..:.....|.|| ..|||
  Rat   656 RLYRARAG------YLTTPHPRAFTNYMKPTSFGPPDLSSGTPPFPYA-TLSPP 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kirreNP_001245505.1 Ig 87..183 CDD:299845 36/95 (38%)
IG_like 88..182 CDD:214653 36/93 (39%)
C2-set_2 189..279 CDD:285423 24/91 (26%)
Ig_2 307..379 CDD:290606 24/76 (32%)
I-set 382..462 CDD:254352 29/86 (34%)
IGc2 396..446 CDD:197706 19/50 (38%)
Ig 466..561 CDD:299845 21/102 (21%)
IG_like 478..561 CDD:214653 19/90 (21%)
Kirrel2XP_038957463.1 IG_like 38..127 CDD:214653 36/93 (39%)
Ig strand A' 40..44 CDD:409353 1/3 (33%)
Ig strand B 48..57 CDD:409353 3/8 (38%)
Ig strand C 62..66 CDD:409353 2/3 (67%)
Ig strand D 75..85 CDD:409353 5/9 (56%)
Ig strand E 88..100 CDD:409353 3/11 (27%)
Ig strand F 107..115 CDD:409353 4/12 (33%)
Ig strand G 117..127 CDD:409353 6/9 (67%)
Ig 133..231 CDD:416386 27/100 (27%)
Ig strand A 134..137 CDD:409353 1/2 (50%)
Ig strand A' 140..144 CDD:409353 0/3 (0%)
Ig strand B 151..158 CDD:409353 3/6 (50%)
Ig strand C 164..169 CDD:409353 1/4 (25%)
Ig strand C' 172..174 CDD:409353 1/4 (25%)
Ig strand D 177..184 CDD:409353 1/6 (17%)
Ig strand E 191..199 CDD:409353 2/7 (29%)
Ig strand F 208..216 CDD:409353 3/7 (43%)
Ig strand G 222..228 CDD:409353 1/5 (20%)
Ig_3 234..303 CDD:404760 21/79 (27%)
Ig strand B 252..256 CDD:409353 1/3 (33%)
Ig strand C 266..270 CDD:409353 2/3 (67%)
Ig strand E 283..286 CDD:409353 0/2 (0%)
Ig strand F 292..301 CDD:409353 2/8 (25%)
Ig strand G 309..312 CDD:409353 0/2 (0%)
Ig 326..403 CDD:416386 28/80 (35%)
Ig strand A' 327..332 CDD:409353 1/4 (25%)
Ig strand B 335..344 CDD:409353 2/8 (25%)
Ig strand C 350..354 CDD:409353 1/3 (33%)
Ig strand C' 357..359 CDD:409353 0/1 (0%)
Ig strand D 362..365 CDD:409353 0/2 (0%)
Ig strand E 366..371 CDD:409353 1/4 (25%)
Ig strand F 379..387 CDD:409353 4/7 (57%)
Ig strand G 393..403 CDD:409353 4/13 (31%)
Ig 405..509 CDD:416386 21/105 (20%)
Ig strand A 406..410 CDD:409353 1/3 (33%)
Ig strand A' 412..415 CDD:409353 0/2 (0%)
Ig strand B 423..430 CDD:409353 1/6 (17%)
Ig strand C 437..442 CDD:409353 1/4 (25%)
Ig strand C' 444..447 CDD:409353 0/2 (0%)
Ig strand D 455..462 CDD:409353 1/6 (17%)
Ig strand E 472..479 CDD:409353 2/6 (33%)
Ig strand F 490..497 CDD:409353 2/6 (33%)
Ig strand G 500..507 CDD:409353 1/6 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342411
Domainoid 1 1.000 87 1.000 Domainoid score I7807
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 259 1.000 Inparanoid score I3044
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 1 1.000 - - FOG0001084
OrthoInspector 1 1.000 - - mtm8946
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1593
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.760

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