DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	878	Identity:	236/878 - (26%)
Similarity:	358/878 - (40%)	Gaps:	199/878 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFS 145
            |..|:.||.||:.|:|.||.|.|.|....|.:|||||...||...:|..:.||.::...:.|.::
Zfish    24 GPRFSQEPADQSVVIGERVVLSCVVFNYTGIVQWTKDGLALGIGEDLRAWPRYRVLRIMDVGQYN 88

  Fly   146 LDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECV 210
            |:|....|.||:.|:||.     .|..:|||.||||||:||:.|.|.....::.|......|.||
Zfish    89 LEITSADLTDDSLYECQA-----TEAALRSRRAKLTVLIPPDGPVIEGSPEILLTAGTSFNLTCV 148

  Fly   211 SQGGKPAAEITWI-DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTA 274
            |:|.||.:.|.|. ||   ::.:|.....|.|:|.:|:|.:|.|::.|........|||.|.|.|
Zfish   149 SRGAKPMSTIEWYKDG---IIVEGAHTSTEVLSDRKRVTTKSFLEIQPMDTDTGRNFTCVASNLA 210

  Fly   275 DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTG 339
            ....:.:.:.|.:.:.|.||:|:     ....:.||..|..:|||.|||..:.|||.....::.|
Zfish   211 APLGKRSTVTLNIHHPPTVILSI-----EPRSVLEGERVKFTCQATANPPIMGYRWAKGGVILDG 270

  Fly   340 D----FTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVS 400
            .    |.|     .....:....|.|.|.||||.:..|..:|:.|||:....|..|..|:.:.|:
Zfish   271 ARESVFET-----TADHSFFTEPVSCLVFNAVGSTNVSILVDVHFGPILVVEPRPVTVDVDSDVT 330

  Fly   401 MRCDVAGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIG---AEATLY 461
            :.|..:|||...:.|..:.|..|:..:.:|.|| ||...||:|.|||:|   |.||   .|.||.
Zfish   331 LNCKWSGNPPLTLTWTKKGSSMVLSNSNQLFLKSVSQADAGQYVCKAIV---PRIGVGETEVTLT 392

  Fly   462 VKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPE- 525
            |...|||:|..:|:...|.:.:|.|...|.|..:.|:|:::..:.......    :.|.:.:.:
Zfish   393 VNGPPIISSEPIQYAVRGEKGEIKCYIASTPPPDKIVWAWKENVWEKERGT----LLERYTVEQS 453

  Fly   526 -------GVRAALIIRDSKATHF-GKYNCTVMNSYGGDSLVITL----LREPGNIPVLLVVMGSM 578
                   .|.:.|.|.:.....| ..||||..|::|..:::|||    :.....:||.::..||:
Zfish   454 RPATQGGAVLSTLTINNVMEADFQSTYNCTAWNAFGPGTMIITLEETDIASEDIVPVGVIAGGSV 518

  Fly   579 --FCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLN-ELKSELRSKAYDVEYSEAGG 640
              ..:.::|:..:|..:||:|:|             ||.|..|. ::|.|..:|..::| .||..
Zfish   519 GSSILLLLLLFALIFYLYRQRKS-------------SRRGVTLKPDIKVETVNKETNLE-EEAAS 569

  Fly   641 DGLAINLTQ---SPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQET-- 700
            ...|..:.:   |.:|.|.:.      |...|.|.|.....|.                |.||
Zfish   570 ASTATRMVKAMYSFLPSVSLS------PSTQPFKDDMDLKQDL----------------QTETLE 612

  Fly   701 ----AYKGSPQANGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSAT---------LP 752
                .|:.....|||.:                        |....:..:.|:|         .|
Zfish   613 PKVEEYEAKDPTNGYYN------------------------VRATTHDEVRSSTRSLLYQEFRAP 653

  Fly   753 HSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLLQNGIDSRFSAIYGNPYLRTN-- 815
            :.|:.:.:.||..|...|.   ..|:|.:.:                    |.:..|.|...|
Zfish   654 NPASVSASTGGPANIHPAP---TGRYEARPT--------------------SRMAHNTYAHFNTI 695

  Fly   816 ---SSLLPPLPPPS-------------TANPAA--------TPA-----PPPYHAARHGHAHHAN 851
               |.:.||..|.|             :.||.|        ||.     .||..|   |.|:
Zfish   696 ARASQIQPPANPVSKTTDYPAERGLLESTNPLAFDSYAYSTTPQYRLGFAPPLEA---GPAY--- 754

  Fly   852 GGLKHFVGGAVITTSPVGNVNINGGGGGGSTPS 884
               :.:..|..:.||...||        |..||
Zfish   755 ---EMYPTGQGVGTSQDANV--------GKYPS 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	39/95 (41%)
		IG_like	88..182	CDD:214653	37/93 (40%)
		C2-set_2	189..279	CDD:285423	29/90 (32%)
		Ig_2	307..379	CDD:290606	24/75 (32%)
		I-set	382..462	CDD:254352	30/83 (36%)
		IGc2	396..446	CDD:197706	17/50 (34%)
		Ig	466..561	CDD:299845	24/103 (23%)
		IG_like	478..561	CDD:214653	19/91 (21%)
kirrel1b	XP_017212964.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582417
Domainoid	1	1.000	84	1.000	Domainoid score	I8167
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm6357
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.660