DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	679	Identity:	184/679 - (27%)
Similarity:	286/679 - (42%)	Gaps:	120/679 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSR 71
            |:||....|....||:       |..:|:|...::|....|||.:....|.:||||....||..|
Human    10 LVLLFCFRGRAGPSPH-------FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQR 67

  Fly    72 DLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPK 136
            ||.|:.||.:.|:...|.:.|.|.||.|:|:|.|:||.:     |..:||..|.|.||||||||:
Human    68 DLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQAT-----QAGLRSRPAQLHVLVPPEAPQ 127

  Fly   137 ITQGDVIYATEDRKVEIECVSVG-GKPAAEITWI-DGLGNVLTDNIEYTVIPLPDQRRFTAKSVL 199
            :..|..:.........:.|.|.| .:|..|:.|. ||   ||.|...:....|.:....:.:|.|
Human   128 VLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG---VLLDGATFHQTLLKEGTPGSVESTL 189

  Fly   200 RLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVH 264
            .|||........|.|:|::.|..|.|...|.:.::|.|:|.::                  .|.|
Human   190 TLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS------------------ASPH 236

  Fly   265 MSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIG--GQKTEMVIRNVTRKFHDAIVKCEV 327
                 .:.|..:|...|:|.|.|....|||.....|::|  |.:.|:|   ....|....|.|||
Human   237 -----TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVV---ADASFLTEPVSCEV 293

  Fly   328 QNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTST 392
            .|:||.:..|..||:.:.|..:.:|:.:..|||...|.:|....||.|.:.|.:....:|:|:..
Human   294 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGA 358

  Fly   393 NLTF-SVSNETAGRYYCK--ANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIEC--FA 452
            .|.. ||..|.||.|.|:  |.:.|....:|:|.:.:...|.:.:..:....:...||::|  ||
Human   359 TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFA 423

  Fly   453 SSVPRARHVSWTFNGQEISSESGHDYSILVDAVPG---------GVKSTLIIRDSQAYHYGK-YN 507
            |..|.|  |.|:::  |...|:|.....||:..|.         |:.|.|.|..:|...:.: :|
Human   424 SPAPDA--VVWSWD--EGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484

  Fly   508 CTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVV------------YIKCKK 560
            |:..|..|...|:..| .::.:...:.||.|::.....|::.|..|.            :.:.|.
Human   485 CSARNRLGEGGAQASL-GRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKN 548

  Fly   561 RTKLP-----------------------------PADVISEHQITKNGGVSCKLEPGDRTSNYSD 596
            ..::|                             .:|::.|.:.|        ||..|.|:.|..
Human   549 LMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEEGT--------LETKDPTNGYYK 605

  Fly   597 LK---VDISGGYVPYGDYSTHYSPPPQYL 622
            ::   |.:|.|..|.|..   :.|||..|
Human   606 VRGVSVSLSLGEAPGGGL---FLPPPSPL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	37/95 (39%)
		Ig	42..114	CDD:299845	29/71 (41%)
		C2-set_2	135..225	CDD:285423	24/91 (26%)
		Ig_3	265..329	CDD:290638	19/65 (29%)
		I-set	346..420	CDD:254352	23/76 (30%)
		Ig	360..425	CDD:299845	21/67 (31%)
		Ig5_KIRREL3-like	428..524	CDD:143235	27/107 (25%)
		IG_like	435..524	CDD:214653	26/100 (26%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	36/93 (39%)
		IGc2	38..106	CDD:197706	29/67 (43%)
		I-set	126..224	CDD:254352	26/100 (26%)
		Ig2_KIRREL3-like	141..223	CDD:143236	24/84 (29%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	25/100 (25%)
		IG_like	234..308	CDD:214653	26/81 (32%)
		Ig	312..395	CDD:299845	25/82 (30%)
		I-set	317..395	CDD:254352	24/77 (31%)
		Ig	397..501	CDD:299845	28/108 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		8/63 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148515
Domainoid	1	1.000	87	1.000	Domainoid score	I7984
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3128
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760