DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and kirrel3b

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	835	Identity:	218/835 - (26%)
Similarity:	345/835 - (41%)	Gaps:	177/835 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYS 91
            |..|:.:|||...|.|..|||||.:....|.:.|.:|...||..|||||:.|||:||....|::.
Zfish    28 NAVFSQQPQDLVVVAGQPVTLPCSIPGYHGVVLWLRDGLALGVGRDLSGYPRYAVVGDHGSGEHH 92

  Fly    92 LDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECV 156
            |.|..|.|.|||.::||..     |.|:||..|.|||||||:.|.||.|.|:.......:.:.|.
Zfish    93 LRIQKVELMDDAVFECQAI-----QAAMRSRPARLTVLVPPDDPMITGGPVVSLRAGDPLNLTCH 152

  Fly   157 SVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTAD 221
            :...||||.|.||.. |.|| :...|:...|.|.||.:..|.|.::...........|:|.|.|.
Zfish   153 ADNAKPAASIIWIRN-GEVL-NGAMYSKTLLRDGRRESTVSTLYISASNIESGQKIICRASNKAV 215

  Fly   222 RTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADAN 286
            ...:...:.:::::.|.|.::|                       ....::|.:.|:..|.|.||
Zfish   216 PNGKETSVTIDIQHLPLVNLSV-----------------------EPQPVLEGNLVKFHCSAKAN 257

  Fly   287 PSDVRYRWFINDEPI--IGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFR 349
            |...:|:|......|  :.|...|::   |...|....|.|||.|.:|.:..|..:|:.:.|...
Zfish   258 PPVTQYKWAKGGSVIKEVSGDTYEVI---VDHSFFTEPVSCEVTNPLGSTNISRNVDVYFGPRMA 319

  Fly   350 QRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTSTNLTF-SVSNETAGRYYCKANVP 413
            ..|||::.|:||.....|....||...|||::..|..|:.....||. ||..|.||:|.|:|.||
Zfish   320 AEPQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENILTLKSVRQEDAGKYVCRAVVP 384

  Fly   414 GYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDY 478
            .......:..:.:.|.|.|.|.:|.....|:..:|:||..|.|....::|::....:.|.:...|
Zfish   385 RVGAAEKEVSLTVNGPPTISSTQTHQAPHGEKGQIKCFIRSTPPPDRIAWSWKETVLESGTSGRY 449

  Fly   479 SILVDAVPGGVKSTL-----IIRDSQAYHYGKYNCTVVNDYGNDVAEIQL--QAKKSVSLLMTIV 536
            ::...:...||.|||     :..|.|..    ||||..|.:|:|...|:|  |.....||.:.::
Zfish   450 TVETVSTEDGVLSTLTMSNIVPADFQTI----YNCTAWNSFGSDTEIIRLKEQGGSQDSLPVAVI 510

  Fly   537 GGISVVAFLLVLTILVVVYIKCKKRTK------------------LPPADVISEHQI-----TKN 578
            .|::|.||:..:.::..:...|..|::                  ||.:....:.::     |:|
Zfish   511 IGVAVGAFVAFIVLMGTIGAFCCTRSQRKKSAHLCTEDAHLVMPTLPTSICAQQRELASKIKTEN 575

  Fly   579 --GGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIM----- 636
              |.||.|          :|::|:|     .:.|::....         |.:.:|...:|
Zfish   576 LKGVVSAK----------NDIRVEI-----VHKDHNAARE---------SEEHSGMKQLMIERGE 616

  Fly   637 --QNNHQNQLQ-LQQQQQQSHH---------------QHHTQTTTLPMTFLTNSSGGSLTGSIIG 683
              |.:...||: ||:::::..|               :||...||:        :|...|
Zfish   617 FQQESVLKQLEVLQEEEKEYQHIKDPTNGYYSVNTFKEHHGTPTTM--------AGNQTT----- 668

  Fly   684 SREIRQD--------NGLPSLQSTT--ASVVSSSPN---------------------------GS 711
              |:|:|        ..:|:..|.|  .|.:.:.||                           ||
Zfish   669 --ELRRDPATATTGKQRVPTGMSFTNIYSTLGAGPNRLYDYSQRFVLGMGSSSIELCEREFQRGS 731

  Fly   712 CSNQS----TTAATTTTTHVVVPSSMALSVDPRYSAIYGNPYLRSS--NSSLLPP 760
            .|:.|    |...::.:::......:....|.:.||...:.|.:||  ||.|..|
Zfish   732 MSDSSSFLDTQCDSSVSSYSKQDGYVQFDKDSKASASSSSHYSQSSSQNSDLTRP 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	43/95 (45%)
		Ig	42..114	CDD:299845	31/71 (44%)
		C2-set_2	135..225	CDD:285423	27/89 (30%)
		Ig_3	265..329	CDD:290638	18/65 (28%)
		I-set	346..420	CDD:254352	27/74 (36%)
		Ig	360..425	CDD:299845	22/65 (34%)
		Ig5_KIRREL3-like	428..524	CDD:143235	30/102 (29%)
		IG_like	435..524	CDD:214653	26/95 (27%)
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653	41/93 (44%)
		Ig2_KIRREL3-like	146..227	CDD:143236	22/82 (27%)
		Ig_2	235..312	CDD:316418	22/102 (22%)
		I-set	316..397	CDD:333254	27/80 (34%)
		Ig5_KIRREL3	399..496	CDD:143306	29/100 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm6357
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870