DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and igsf9ba

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_009289969.2	Gene:	igsf9ba / 567389	ZFINID:	ZDB-GENE-060503-729	Length:	1475	Species:	Danio rerio

Alignment Length:	979	Identity:	206/979 - (21%)
Similarity:	333/979 - (34%)	Gaps:	301/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LATIVGMVRSSPYTSYQNQR-FAMEPQDQTAVVGARVTLPCRV---INKQGT---LQWTKDDFGL 67
            :||::..|.|:..|:.|... ...|||..||..|..|.|.|.|   :|.|.|   ::|.|  ||:
Zfish     5 VATLIASVFSTRGTAAQGAHGVREEPQFVTARAGESVVLGCDVSHPLNGQQTPYVVEWFK--FGV 67

  Fly    68 GTSRDLSGFERYAMVGSDE-------EGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRS-TFA 124
            .....:: |..|......|       .|..||.|..|..:|...|:|:|....:......: ::.
Zfish    68 PIPFFIN-FRFYPPHVDPEYAGRASLHGKASLQIEQVRSEDQGWYECRVLMLEQQYDTFHNGSWV 131

  Fly   125 GLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTV----- 184
            .|||..||.... |....:.|.|...:.:.|.:. |.|...:||:.. |:.||...:|||
Zfish   132 HLTVNAPPTFSD-TPPQYVEAREGGSITLTCTAF-GNPKPVVTWLRE-GDQLTSTRKYTVSDGSL 193

  Fly   185 ----IPLPDQRRFTAKS---------VLRL---------TPKKE-----HHNTNFSCQAQN---- 218
                |...|:..::.::         ..||         ||.:.     ..|..|:|||:.
Zfish   194 TVQAITREDRGAYSCRAHSDQGEALHTTRLLVQGPPYIVTPPENITVNISQNAQFTCQAEAYPGN 258

  Fly   219 -------TADRTYRSAKIRVEVKYAPKVKVNVMGSL------PGGAG-------GSVGGAGGGSV 263
                   ..|..|....:::      :|::.:.|:|      |..||       .|:|.:...|.
Zfish   259 LTYTWYWEEDNVYFKNDLKL------RVRIFIDGTLIIYRVKPEDAGKYTCSPSNSLGISPSASA 317

  Fly   264 HMST--GSRIVEHSQV---------RLECRADANPSDVRYRWFINDEPII------GGQKTEMVI 311
            :::.  .:|:|....|         .:.|..||||.....||..:..|:.      ..|.|:..|
Zfish   318 YLTVQYPARVVNMPPVIYVPRKLSGIIRCPVDANPPVTSVRWEKDGYPLRIEKYPGWSQMTDGSI 382

  Fly   312 RNVTRKFHDAI-----VKCEVQNSVGKSEDSETLDISYAPSFRQRP-QSMEADVGSVVSLTCEVD 370
            | |.....|::     |...|..::|:|..: ||.:...|.|..|| .....:.|..:.:.|...
Zfish   383 R-VAEVTEDSLGTYTCVPYNVLGTMGQSPPA-TLVLKDPPYFNVRPGGEYRQEAGRELVIPCAAS 445

  Fly   371 SNPQ-PEIVWIQHPSDRVVG----------TSTNLTF-SVSNETAGRYYCKA-NVPGYAEISADA 422
            .:|: |.|.|      |.||          .|.:|.| |:|.|..|.:.|.| ||  ...|:|..
Zfish   446 GDPEIPTIQW------RKVGKPSRSKHNLLPSGSLQFVSLSKEDHGEWECVATNV--VTSITAST 502

  Fly   423 YVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPG 487
            .:::.|:                      :...|...|||.:.:...:|.|.|:|         |
Zfish   503 RLFVIGT----------------------SPHAPTNVHVSASTSSANVSWEPGYD---------G 536

  Fly   488 GVKSTLIIRDSQAYHYGKYNCTVVNDYG-NDVAEIQLQAKKSVSLLMTIVGGI--------SVVA 543
            |.:.|..:      .||...  |.||.| :|...|.:..    |.:..:|.|:        ||:|
Zfish   537 GFEQTFSV------WYGPVK--VKNDVGTHDWLSIPVPG----SQMWLVVQGLEPKTAYQFSVLA 589

  Fly   544 --------FLLVLTI-------------LVVVYIKC--KKRTK-------LPPAD-------VIS 571
                    |..|:|:             :::...:|  ..||:       ||||:       .:.
Zfish   590 QNKLGTGPFSEVVTVTTGGYPISTPEPLVLLTPPRCLTANRTQQGVLLTWLPPANHTSPIDRYVI 654

  Fly   572 EHQITKNGGVSCKLEPGDRTSNYS-DLKVD--------------ISGGYVPYGDYSTHYSPPPQ- 620
            |.::.:...|...|.|...|...: ||..|              :|......|..||...||.:
Zfish   655 EFRLGEKWEVLDDLIPATETEIIARDLIQDSWYEFRALAIMDDLVSESSNVVGVSSTDPFPPTEI 719

  Fly   621 ------------------YLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQS-HHQHHTQTTTLPM 666
                              :|......|..::..:...|:.:|:.::....| .|...:..:..|:
Zfish   720 SDEGLAKPVVAGIVATICFLAAAILFSTLAACFVNKQHRRKLKRKRDPPLSITHTRKSIESPPPL 784

  Fly   667 TFLTN----------------------SSGGSLTGSIIGSR------------------EIRQDN 691
            |.|..                      |||.....||..||                  ..|::.
Zfish   785 TPLPGIEPYWEEPDRSSYRPPSTSPQLSSGKISPESIASSRPPSLASVGGHGLYVKKLPSPRKEK 849

  Fly   692 GLPSLQSTTASVVSSSPNGSCSNQSTTAATTTTTH------VVVPSSMALSVDPRYSAIYGNPYL 750
            .|...:.|..::.|...:.|......|......:.      |:.|:.:..|:.||  .|.|.|::
Zfish   850 ELSLYKKTKRAITSKKYSVSKHEAEVTTPIELISRGPDGRFVMDPNDIDSSLKPR--RIEGFPFV 912

  Fly   751 RSSN 754
            ..|:
Zfish   913 EESD 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	31/109 (28%)
		Ig	42..114	CDD:299845	24/84 (29%)
		C2-set_2	135..225	CDD:285423	26/132 (20%)
		Ig_3	265..329	CDD:290638	19/85 (22%)
		I-set	346..420	CDD:254352	25/87 (29%)
		Ig	360..425	CDD:299845	22/77 (29%)
		Ig5_KIRREL3-like	428..524	CDD:143235	20/96 (21%)
		IG_like	435..524	CDD:214653	19/89 (21%)
igsf9ba	XP_009289969.2	IG	30..115	CDD:214652	27/87 (31%)
		I-set	139..225	CDD:254352	19/88 (22%)
		I-set	229..321	CDD:333254	18/97 (19%)
		Ig	345..415	CDD:325142	19/71 (27%)
		Ig	438..503	CDD:319273	21/72 (29%)
		FN3	511..606	CDD:238020	28/115 (24%)
		FN3	622..706	CDD:238020	16/83 (19%)
		Atrophin-1	<924..1361	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900