DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rst and lrit3a

DIOPT Version :9

Sequence 1:NP_001284835.1 Gene:rst / 31290 FlyBaseID:FBgn0003285 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_001122166.1 Gene:lrit3a / 558559 ZFINID:ZDB-GENE-080723-63 Length:636 Species:Danio rerio


Alignment Length:448 Identity:76/448 - (16%)
Similarity:138/448 - (30%) Gaps:177/448 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 LDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVW------------IQHPSDRVVGTST 392
            ||....|:.......:.:.:||.|.|.|:.:..|.|.::|            :|......|..|.
Zfish   246 LDQCVKPTVMTSATKITSPLGSNVLLRCDANGFPTPTLLWTTADGSVVNNTVVQESPGEGVRWSI 310

  Fly   393 NLTFSVSNETAGRYYCKA-NVPGYAEISADAYVYL------------------------------ 426
            ....|:..:.||.|.||| ||.|    :|:||:.|                              
Zfish   311 LSLHSIVFKDAGDYRCKAKNVAG----NAEAYITLSVDGVQPTTPFPPINITKQPEDQPTTTFTP 371

  Fly   427 --------------------------------------KGSPAIGS-----QRTQYG----LVGD 444
                                                  :.||..|.     |:::.|    ...|
Zfish   372 TKMPLFTSLSPITITTRPVMTTMPPLTTRKSPIPGGGVQRSPPAGDKPAKVQQSKNGKGSIKKSD 436

  Fly   445 TARIECFASSVPRARHVSWTFNG--------------------QEISSESGHDYSILVDAVPGGV 489
            ...||....:...| .:.|:..|                    :.:.:|.|....:|...:|..|
Zfish   437 IRDIEVVEETTETA-VLLWSAEGLPSDTPLTVVYFPYDAKDDKETVDTEVGQGKLLLEYLMPNQV 500

  Fly   490 KSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGI--SVVAFLLVLTILV 552
            .:..::..|.    ||..|.       |.:.:::..::..:.::.|...|  ::...|:|:.:..
Zfish   501 YTVCLVTKSS----GKEQCV-------DFSTLEIGGEEGQNKVLMIASAIACAIAVPLIVVLLYK 554

  Fly   553 VVYIKCKKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSP 617
            ::.:.||..:             ::|.|      |.:      ||..|.   ||.:         
Zfish   555 ILCLYCKGNS-------------SRNNG------PDE------DLSKDT---YVKF--------- 582

  Fly   618 PPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHTQTTTL--PMTFLTNSS 673
              :.||......||.:        |.|..::|.|:|........:::  .||:.::||
Zfish   583 --ETLTMKQRTLNGQA--------NDLWARRQTQESERMLLCSRSSIDSQMTYKSDSS 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rstNP_001284835.1 IG_like 34..130 CDD:214653
Ig 42..114 CDD:299845
C2-set_2 135..225 CDD:285423
Ig_3 265..329 CDD:290638
I-set 346..420 CDD:254352 22/86 (26%)
Ig 360..425 CDD:299845 24/77 (31%)
Ig5_KIRREL3-like 428..524 CDD:143235 21/124 (17%)
IG_like 435..524 CDD:214653 18/112 (16%)
lrit3aNP_001122166.1 LRR_8 81..141 CDD:290566
leucine-rich repeat 83..106 CDD:275378
LRR_4 107..145 CDD:289563
leucine-rich repeat 107..130 CDD:275378
LRR_8 129..>171 CDD:290566
LRR_4 129..170 CDD:289563
leucine-rich repeat 131..154 CDD:275378
leucine-rich repeat 155..168 CDD:275378
TPKR_C2 199..249 CDD:301599 2/2 (100%)
Ig 252..343 CDD:299845 26/94 (28%)
IG_like 261..343 CDD:214653 25/85 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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