DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and si:dkey-24p1.1

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001091715.1	Gene:	si:dkey-24p1.1 / 556718	ZFINID:	ZDB-GENE-060503-631	Length:	1043	Species:	Danio rerio

Alignment Length:	934	Identity:	191/934 - (20%)
Similarity:	309/934 - (33%)	Gaps:	306/934 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YTSYQNQRFAMEP---QDQTAVVGARVT---------LPCRVINKQGTLQWTKDDFGLGTSRDLS 74
            :||..::...:|.   ::.|.|...::|         |.||..|...:.|..    .:..|.:.|
Zfish   203 WTSSPSKEMIIETEKGENGTQVTKLKLTVTWKDDNRILSCRPANSDDSCQIR----NITLSVEYS 263

  Fly    75 GFERYAMVGSDE-----------------EGDYS--------------LDIYPVMLDDDARYQCQ 108
            ..|.:|.|.|::                 |..|:              ||:..:..:|...|.|:
Zfish   264 PKETHASVSSNDVKETNSVTLSCTSRGRPEVTYTWFKKNKGKLQQISDLDLRQMKPEDSGEYYCE 328

  Fly   109 VSPG----PEGQPAIRSTFA--GLTVLVPPEAPKITQGDVIYATEDRKVEIEC-VSVGGKPAAEI 166
            ....    ...:.:|...|.  |:||..|.....|.:||.        |.::| |.....||:..
Zfish   329 AKNSLGVMKSNEISINVKFGPKGVTVTPPYNINDIKEGDT--------VTLKCSVERQNPPASRF 385

  Fly   167 TWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRV 231
            .|..  .|.:......|.|    .|:.||..            ..:.|:|.|..::. :|.::.|
Zfish   386 VWYK--NNRIQQETSETFI----DRKVTAAV------------QKYKCEANNGINKG-QSQELTV 431

  Fly   232 EVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWF- 295
            .|||:|: .:|:.                |...:..|||:      .|.|.|||:|..| |:|.
Zfish   432 NVKYSPR-NINIQ----------------GKTSVKVGSRL------ELTCSADAHPQPV-YKWTF 472

  Fly   296 ---INDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEA 357
               ::..|:   .|.::..:.||.: |.....|.|.|::|...:|..:.:.|.|  |.....|::
Zfish   473 PPGLSFSPL---SKGKLETQPVTIE-HAGEYTCGVTNTIGTKSESTNVKVLYPP--RNINLMMQS 531

  Fly   358 DVG--SVVSLTCEVDSNPQPEIVWIQH-------PSDRVVGTSTN----LTFSVSNETAGRYYCK 409
            :|.  .|:|:.|.|.|.|..:....::       |..|...|...    :..:|:...||.|.|.
Zfish   532 EVREFEVISVICTVQSFPTSKFTVTKNLDNLLNIPECRRNSTEYENKVIIFLNVTESDAGTYKCT 596

  Fly   410 A-NVPGYAEISADAYVY---------LKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWT 464
            | |..|..|.:....|.         .||.....|:.|          :.|.|.|.|......||
Zfish   597 AKNTEGQEETNKKLTVLYAPKNVTASFKGDQKSASELT----------LTCEACSNPPVSSYEWT 651

  Fly   465 -----------------FNGQEISSESG-------------------------------HD---- 477
                             ||..|| |:||                               |:
Zfish   652 KLNNGQFETLKQHQQLHFNSLEI-SDSGQYVCIAYNAIGKAKSPPLDIRVKYTPNITIVHNTTTS 715

  Fly   478 --------YSILVDAVPGGVK--------STLIIRDSQAY-----HYGKYNCTVVNDYG-NDVAE 520
                    .|.:.||.|...:        :|.::...|.:     :.|.|.||..||.| :...:
Zfish   716 AQWNLPVYLSCIADAHPPATEYKWYRQEDNTTVLSQQQNFTVLPQNPGLYYCTATNDIGLSRSKQ 780

  Fly   521 IQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQ----------- 574
            |.|....|:|:.:.||   ..:.||||| |:||:::..:...|     :.|:.|
Zfish   781 IALFVSTSLSVFLKIV---LPIIFLLVL-IVVVIFLIRRNIIK-----IRSDQQSGADNLLCLFP 836

  Fly   575 --ITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQ 637
              ::::..|......|.|.:...:|.:|...    |...:..|...|.                |
Zfish   837 AFLSRSSRVQNLFLLGSRNNTQENLSLDDPN----YAQVNLSYPIQPS----------------Q 881

  Fly   638 NNHQNQ----------------LQLQQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSRE 686
            |..|.|                ::|.|::|:.|.....|.|    ..:.|:|...:|....|..|
Zfish   882 NPTQGQDLNPRPKPNIQTVYAAIKLPQKKQKRHSPKQQQKT----GNMDNTSMNYVTLDFKGQNE 942

  Fly   687 IRQDNGLPSLQSTTASV-------VSSSPNGSCSNQSTTAA------------TTTTTHVVVPSS 732
            .|:.  :|...:..|.|       .|.:.|....|.|:..|            .|:....|..|:
Zfish   943 PRKI--MPETSAVYAMVSRNKQAKSSQAENSDYENVSSACAPKLPLTNMEWESDTSEEEEVNYST 1005

  Fly   733 MALSVDPRYSAIYGNPYLRSSNSS 756
            ::.|..|....:..|.....|:||
Zfish  1006 VSCSTKPAVKEVKPNQKRHFSSSS 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	26/144 (18%)
		Ig	42..114	CDD:299845	19/115 (17%)
		C2-set_2	135..225	CDD:285423	18/90 (20%)
		Ig_3	265..329	CDD:290638	19/67 (28%)
		I-set	346..420	CDD:254352	22/87 (25%)
		Ig	360..425	CDD:299845	18/78 (23%)
		Ig5_KIRREL3-like	428..524	CDD:143235	31/169 (18%)
		IG_like	435..524	CDD:214653	29/162 (18%)
si:dkey-24p1.1	NP_001091715.1	Ig	37..153	CDD:299845
		IG_like	276..345	CDD:214653	8/68 (12%)
		IGc2	280..334	CDD:197706	7/53 (13%)
		IG_like	364..431	CDD:214653	18/93 (19%)
		Ig_2	365..433	CDD:290606	19/94 (20%)
		IG_like	443..518	CDD:214653	23/101 (23%)
		IGc2	451..508	CDD:197706	20/67 (30%)
		IG_like	532..612	CDD:214653	19/79 (24%)
		Ig	<570..602	CDD:299845	8/31 (26%)
		IG_like	616..694	CDD:214653	17/88 (19%)
		Ig_2	631..700	CDD:290606	15/79 (19%)
		IG_like	721..791	CDD:214653	16/69 (23%)
		Ig_2	721..785	CDD:290606	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910