DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and SDK2

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	696	Identity:	142/696 - (20%)
Similarity:	230/696 - (33%)	Gaps:	264/696 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLATIVGM--VRS-------SPYTSYQNQRFAMEP-QDQTAVVGARVTLPCRVINKQGTLQWTK 62
            ||:.|::.:  :|:       |||       |..|| :.|..:.|.|:.|.|..   :|:  |..
Human     4 LLIWTLLALHQIRAARAQDDVSPY-------FKTEPVRTQVHLEGNRLVLTCMA---EGS--WPL 56

  Fly    63 DDFGLGTSRDLSGFE---RY---------------------------------AMVGSDEEG--- 88
            :...|..:|:|:.|.   ||                                 |.:||.|||
Human    57 EFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKH 121

  Fly    89 -------------------------------------------DYSLDIYPVMLDDDARYQCQVS 110
                                                       :.:|.|...:..|..||..|..
Human   122 QSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAV 186

  Fly   111 PGPEG-----QPAIRSTFAGL---------TVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGK 161
            ....|     || |..|...:         |:::||:...:..|       ..:|.:|||: ..:
Human   187 NDKNGDNKTSQP-ITLTVENVGGPADPIAPTIIIPPKNTSVVAG-------TSEVTLECVA-NAR 242

  Fly   162 PAAE--ITW-IDG--LGNVLTDNIEYTVIPLP---DQRRFTAKSVLR---------------LTP 203
            |..:  |.| .||  |...::|:.....||.|   |...:..::|||               |.|
Human   243 PLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP 307

  Fly   204 -----KKEHHNT-------NFSCQAQNTADRT---YRSAKIRVEVKYAPKVKVNVMGSLPGGAGG 253
                 :.|.|.|       :..|||:.....:   |:.|.: |||:...:.:..
Human   308 PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV-VEVEKLTRFRQR----------- 360

  Fly   254 SVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKF 318
                                                       ||    ||.:...::.:.|..|
Human   361 -------------------------------------------ND----GGLQISGLVPDDTGMF 378

  Fly   319 HDAIVKCEVQNSVGKSEDSETLDI-SYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQH 382
                 :|..:|:.|:.:.|..|.: |.||:..:.|.......|..|.|.||....|:|.|.|  .
Human   379 -----QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITW--Q 436

  Fly   383 PSDRVVGT------------STNLTFSVSN-ETAGRYYCKA-NVPGYAEISADAYVYLKGSPAIG 433
            ..:|::.:            |.:|..|.:: ..||.|.|.| |..|..|.|||..|:.: :....
Human   437 KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWAR-TRITK 500

  Fly   434 SQRTQYGLVGDTARIECFASSVPRA--RHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIR 496
            ..:.|..:.|..|.:.|..:..||.  |:: |..:|..:.:|| |. .|.:|.     ..:|.|.
Human   501 PPQDQSVIKGTQASMVCGVTHDPRVTIRYI-WEKDGATLGTES-HP-RIRLDR-----NGSLHIS 557

  Fly   497 DSQAYHYGKYNCTVVNDYGNDVAEIQLQAKK-------SVSLLMTI 535
            .:.:...|.|.|.|::..|||.....|:.::       .|:.|.|:
Human   558 QTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTV 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	32/192 (17%)
		Ig	42..114	CDD:299845	24/153 (16%)
		C2-set_2	135..225	CDD:285423	27/127 (21%)
		Ig_3	265..329	CDD:290638	7/63 (11%)
		I-set	346..420	CDD:254352	23/87 (26%)
		Ig	360..425	CDD:299845	24/78 (31%)
		Ig5_KIRREL3-like	428..524	CDD:143235	23/97 (24%)
		IG_like	435..524	CDD:214653	23/90 (26%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845	17/93 (18%)
		IG_like	40..109	CDD:214653	12/73 (16%)
		I-set	120..203	CDD:254352	10/83 (12%)
		Ig	132..210	CDD:299845	11/78 (14%)
		IG_like	222..304	CDD:214653	19/89 (21%)
		IGc2	233..286	CDD:197706	15/53 (28%)
		I-set	308..397	CDD:254352	22/152 (14%)
		Ig	326..394	CDD:143165	18/131 (14%)
		I-set	402..492	CDD:254352	26/91 (29%)
		Ig	416..492	CDD:299845	24/77 (31%)
		Ig	502..586	CDD:299845	24/91 (26%)
		IG_like	502..586	CDD:214653	24/91 (26%)
		FN3	590..681	CDD:238020	3/14 (21%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900