DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and opcml

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001005580.1	Gene:	opcml / 449538	ZFINID:	ZDB-GENE-040927-3	Length:	342	Species:	Danio rerio

Alignment Length:	354	Identity:	77/354 - (21%)
Similarity:	135/354 - (38%)	Gaps:	62/354 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 VKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPII- 302
            |.:.::..:|.|.     .|..|..::.....:.:.....|:|..|...|  |..| :|...|:
Zfish    17 VALRLLFLVPAGV-----PARSGDSYLKDNITVRQGDSAVLKCSMDNKVS--RVAW-LNRTTILF 73

  Fly   303 -GGQKTEM-----VIRNVTRKFHDAIVKCEVQN------SVGKSEDSETLDISYAPSFRQRPQSM 355
             |.:|..:     ::.....::...|:...:.:      |:..::..|:..:........|..::
Zfish    74 TGNEKWSLDPRVVLLNTAVNEYSIKILNVNLYDEGPYVCSILTNKKPESTKVHLIVQVPARIVNV 138

  Fly   356 EADV----GSVVSLTCEVDSNPQPEIVWIQHPS--DRVV--GTSTNLTFSVSNETAGRYYCKANV 412
            ..||    ||.|||.|.....|:|.|:|....|  :|:|  |....:| .::.:.:|.|.|..:
Zfish   139 STDVSVNEGSNVSLMCLAIGRPEPSILWKFRSSKGNRIVTEGEYVEMT-GITKDMSGSYDCITS- 201

  Fly   413 PGYAEIS----ADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRA--------RHVSWTF 465
               .:||    ....|.:...|.|...|:....||....:.|.||:||.|        |.:...|
Zfish   202 ---NDISPPDVRTVQVTVNYPPVISRARSTGTAVGQKGVLWCEASAVPLADFQWFKGERRILNGF 263

  Fly   466 NGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVS 530
            ||.:|.::              |.:|.|...:.....||.|.|..:|..|...|.|.|....::.
Zfish   264 NGVKIENK--------------GKQSMLTFFNVSEEDYGNYTCVAINTLGITNASIILYGPGAIH 314

  Fly   531 LLMTIVGGISVVAFLLVLTILVVVYIKCK 559
            .:..  ..:|....||:||:|:.:.:..|
Zfish   315 DVNN--AALSPTCSLLLLTLLLTLSLLSK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653
		Ig	42..114	CDD:299845
		C2-set_2	135..225	CDD:285423
		Ig_3	265..329	CDD:290638	11/70 (16%)
		I-set	346..420	CDD:254352	23/85 (27%)
		Ig	360..425	CDD:299845	20/72 (28%)
		Ig5_KIRREL3-like	428..524	CDD:143235	27/103 (26%)
		IG_like	435..524	CDD:214653	25/96 (26%)
opcml	NP_001005580.1	Ig	41..129	CDD:299845	13/90 (14%)
		IG_like	41..129	CDD:214653	13/90 (14%)
		IG_like	139..216	CDD:214653	23/81 (28%)
		IGc2	146..202	CDD:197706	18/60 (30%)
		I-set	219..307	CDD:254352	27/101 (27%)
		ig	223..307	CDD:278476	25/97 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900