DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and negr1

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	340	Identity:	81/340 - (23%)
Similarity:	129/340 - (37%)	Gaps:	58/340 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 GGSVHMSTGSRIVEHSQ---VRLEC--------RADANPSDVRY----RWFINDEPIIG-----G 304
            |.:|..:|.|..|...|   ..|.|        .|..|.|.:.|    :|  :.:|.:.     |
Zfish    35 GQTVDYTTSSESVVSRQGDTALLRCYLLDGISKGAWLNRSSIIYAGNDKW--SGDPRVSIVSNVG 97

  Fly   305 QKTEMVIR----NVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSL 365
            .|.|..::    :||   .:.:..|.:|:..........|.:...|........:..:.||.|||
Zfish    98 DKHEYSLQIQKVDVT---DEGVYTCSIQSERNLHPKLIQLIVKVPPKIYDISSDITVNEGSNVSL 159

  Fly   366 TCEVDSNPQPEIVWIQH--PSDRVV--GTSTNLTFSVSNETAGRYYCKANVPGYAEISADAYVYL 426
            .|.....|:|:|.| :|  ||.|..  |...|:| .:|.:.||.|.|.|.....:..:....|.:
Zfish   160 ICAASGKPEPKISW-RHISPSARKYESGEYLNIT-GISRDQAGDYECGAENDIASPDTKTVRVTV 222

  Fly   427 KGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKS 491
            ...|||...::.....|..|.:.|.|::|| :....|....:.|:...|    |:::.:..  :|
Zfish   223 NFPPAIHEMKSHGVRPGQVALLRCEAAAVP-SPVFEWYKGEKRINMGQG----IVINNLSS--RS 280

  Fly   492 TLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQL------------QAKKSVSLLMTIVGGISVVA- 543
            .|.:::.....||.|.|..||..|...|.:.|            .:..|...:....||..|:.
Zfish   281 VLTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTSAVSSPASNPAMYGSTGGAEVLLA 345

  Fly   544 ---FLLVLTILVVVY 555
               .:|.|:.||.||
Zfish   346 CWYLILALSSLVTVY 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653
		Ig	42..114	CDD:299845
		C2-set_2	135..225	CDD:285423
		Ig_3	265..329	CDD:290638	18/87 (21%)
		I-set	346..420	CDD:254352	24/77 (31%)
		Ig	360..425	CDD:299845	23/68 (34%)
		Ig5_KIRREL3-like	428..524	CDD:143235	24/107 (22%)
		IG_like	435..524	CDD:214653	21/100 (21%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	18/83 (22%)
		IG_like	44..136	CDD:214653	19/96 (20%)
		I-set	140..222	CDD:254352	25/83 (30%)
		IGc2	153..208	CDD:197706	23/56 (41%)
		IG_like	236..312	CDD:214653	20/82 (24%)
		IGc2	238..304	CDD:197706	18/72 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900