DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rst and hbs

DIOPT Version :9

Sequence 1:NP_001284835.1 Gene:rst / 31290 FlyBaseID:FBgn0003285 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_001286439.1 Gene:hbs / 44129 FlyBaseID:FBgn0029082 Length:1235 Species:Drosophila melanogaster


Alignment Length:701 Identity:180/701 - (25%)
Similarity:284/701 - (40%) Gaps:143/701 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 HTMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGL 67
            |.|..:...|....|.:.|.     |:|.:.|.|...:.|....|.|.|.|:.|.:|||||.|.|
  Fly    19 HVMAAVTAPTPAAQVAAPPV-----QKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFAL 78

  Fly    68 GTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPP 132
            |.|..:.||.||:::...::..|:|.|....|:|||.|||||.|. .|.||||:. |.|:::..|
  Fly    79 GFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPA-AGNPAIRAN-AKLSIVAAP 141

  Fly   133 EAPKITQGDVIYATEDRKVEIE--------CVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPD 189
            .: .:.:|   || .:.:||:|        |::....|||||.|..|...|.|..|  ..:....
  Fly   142 SS-IVIEG---YA-RNARVEVEERQNLTLHCIAENANPAAEIVWFQGEVPVSTAPI--VTVNQTA 199

  Fly   190 QRRFTAKSVLRLTPKKEHHNTNFSCQAQNTA---DRTYRSAKIRVEVKYAPKVKVNVMGSLPGGA 251
            .:|||..|.|.|.|:.|.....|||:|::.|   |...| |::::.|.|.|            ||
  Fly   200 PKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMR-AQVQLSVLYPP------------GA 251

  Fly   252 GGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTR 316
            ....|.:.|.::|..        .:|::.||:.......:..|:.|...|...|:|...:.....
  Fly   252 PFFEGYSQGETLHRG--------QEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVY 308

  Fly   317 KF------HDAIVKCEVQNSVGKSEDSETLDIS--YAPSFRQRPQSMEADVGSVVSLTC-EVDSN 372
            ||      :.|.:.||.:|.:..:.....|:::  |||.......:.:|.||..|.|:| ...||
  Fly   309 KFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSN 373

  Fly   373 PQPEIVWI--QHPSDRVVGTSTNLTFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQ 435
            ||..|.|.  ..|.|       |.|:..::.:.|.:...:|:.  ..|.:.:..::....|:.::
  Fly   374 PQARISWSINGRPLD-------NSTYKTTSSSDGGWVSSSNIS--LTIDSQSRTFIAVCHALNTE 429

  Fly   436 RTQ---------------------YG-----LVGDTARIECFASSVPRARHVSWTFNGQEISSES 474
            .||                     |.     :.|...:::|.::.......:.|..|.:.|::.|
  Fly   430 LTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPS 494

  Fly   475 GHDYSILVDAVPGGVKSTLI-IRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLM---TI 535
            .     |||:......|.|: ..|:.|.    |.|.|    .|...:|.|.|.|::.:..   |:
  Fly   495 K-----LVDSKITSELSLLVNASDNNAI----YKCKV----QNAAIDIPLFATKTLGVHFPPETV 546

  Fly   536 VGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQITKNG----GVSCKLEPG------DR 590
              .||||...||..|...:.  |...:..|||.:    ...|:|    |::....||      ..
  Fly   547 --KISVVPKNLVPGIRAKLI--CDSSSSNPPAKI----SWWKDGIPVEGLNLANRPGLWGGSVST 603

  Fly   591 TSNYSDLKVDISGGYVPYG--------DYSTHYS------PPPQYLTTCST 627
            ...|.::..|:.|  :.|.        ..|.|.:      .||::.|..||
  Fly   604 LEMYVNITQDLDG--IVYTCQSHNEVLQRSVHETISLDILYPPKFETPQST 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rstNP_001284835.1 IG_like 34..130 CDD:214653 41/95 (43%)
Ig 42..114 CDD:299845 32/71 (45%)
C2-set_2 135..225 CDD:285423 31/100 (31%)
Ig_3 265..329 CDD:290638 13/69 (19%)
I-set 346..420 CDD:254352 20/76 (26%)
Ig 360..425 CDD:299845 17/67 (25%)
Ig5_KIRREL3-like 428..524 CDD:143235 22/122 (18%)
IG_like 435..524 CDD:214653 21/115 (18%)
hbsNP_001286439.1 Ig 44..122 CDD:299845 33/77 (43%)
IG_like 45..137 CDD:214653 41/93 (44%)
Ig 153..231 CDD:299845 26/79 (33%)
IG_like 258..342 CDD:214653 17/91 (19%)
Ig 266..327 CDD:299845 13/68 (19%)
IG_like 357..>414 CDD:214653 19/65 (29%)
Ig 360..427 CDD:299845 18/75 (24%)
Ig <468..526 CDD:299845 16/70 (23%)
I-set 547..633 CDD:254352 21/93 (23%)
Ig 556..631 CDD:299845 15/82 (18%)
I-set 644..735 CDD:254352 4/9 (44%)
IGc2 668..725 CDD:197706
IG_like 751..829 CDD:214653
IGc2 753..815 CDD:197706
Ig 852..928 CDD:143165
FN3 935..1017 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45451327
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.950

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