DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and sns

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	848	Identity:	204/848 - (24%)
Similarity:	320/848 - (37%)	Gaps:	221/848 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HTMQLLLLATIVGMVRSSPYTSY-QNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFG 66
            |...|.|||.||  :.|:|..|: |.|:|...|.|...:.||...:.|.|.|..|.:|||||.|.
  Fly    48 HLQLLRLLAVIV--LASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFA 110

  Fly    67 LGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVP 131
            ||.|..:.||.||:::|..::|.|:|.|....::|||.|||||.|. ....|||:. |.|||:.|
  Fly   111 LGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPA-RLNSAIRAN-AKLTVISP 173

  Fly   132 PEAPKI---TQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQR-- 191
            |.:.:|   :....:...|::.::::|:....||||:|.|..|       |:||.    |::|
  Fly   174 PASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRG-------NVEYK----PEKRED 227

  Fly   192 --------RFTAKSVLRLTPKKEHHNTNFSCQAQNTA---DRTYRSAKIRVEVKYAPKVKVNVMG 245
                    |||..|.|:|.|..:...|.::|||::.|   |...| |.:::.|.|.|
  Fly   228 TVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMR-ATVQLSVLYPP-------- 283

  Fly   246 SLPGGAGGSVGGAGGGSVHM---STGSRIVEHSQVRLECRADANPSDVRYRWFINDEPI-----I 302
                           |..::   |.|..:.....|.|.||:.......:..|:.|...|     .
  Fly   284 ---------------GPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRT 333

  Fly   303 GGQKTEMVIRNVTRKFHD--AIVKCEVQNSVGKSEDSETLDIS--YAPSFRQRPQSMEADVGSVV 363
            .|:.:|. |...|.:..|  |..:||..|.:.::.....:::|  :||:........||.||.:|
  Fly   334 SGRLSEN-IYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIV 397

  Fly   364 SLTC-EVDSNPQPEIVWIQHPSDRVVGTSTNLTFSVSNETAGRYYCKANVPGYAEISADAYV--- 424
            .||| ...|||..||.|:  ...|.|..:|:.|. ||.|  |.:...:|:....|.:..:.|
  Fly   398 PLTCTTAPSNPPAEIKWM--VGGRQVRNATSKTI-VSPE--GGWTTTSNITAVVEPNKRSLVVIC 457

  Fly   425 --------------------YLKGSPAI-GSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQ 468
                                |....|.| |....|....|...::.|.:|.......::|..|.:
  Fly   458 HGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDK 522

  Fly   469 EISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLM 533
            .|:|        ::.|....|.:.:.|..:.:.:..:|.|    :..|...||.|....::|
  Fly   523 RINS--------VIRAADKSVSAEITILANVSDNQAQYRC----EASNSATEIPLFQSTTLS--- 572

  Fly   534 TIVGGISVVAFL----------------LVLTILVVVYIKCKKRTKLPPADVISEHQITKNG--- 579
                    |.|.                :..||:      |...:..|||.:    ...|:|
  Fly   573 --------VHFAPETVKIRIEPEELRPGMEATII------CDSSSSNPPAKL----SWWKDGIPI 619

  Fly   580 -GVSCKLEPGDRTSNYSDLKVDISGGYVPYGD------------------------YSTHYSPPP 619
             |::...:||......|.|:..::......|.                        |...:.|||
  Fly   620 EGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPP 684

  Fly   620 QYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLT------ 678
                       .|:.:.......|:.||           |:....|:|:.....|.::.
  Fly   685 -----------SSTAVGVEGESLQVSLQ-----------TRANPTPVTYKWTKDGTTIPQDGDHR 727

  Fly   679 -----GSIIGSREIRQDNGLPSLQSTTASVVSSSPNGSCSN------QSTTAATTTTTHVVVPSS 732
                 ||:..:|..|.|.|:.|..:      |:|..|:..|      ..||..:.:...||.|..
  Fly   728 IFADGGSLNFTRLHRDDAGIYSCSA------SNSQGGATLNITVVVEYGTTIKSVSENIVVNPGE 786

  Fly   733 MAL 735
            .|:
  Fly   787 DAM 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	42/95 (44%)
		Ig	42..114	CDD:299845	33/71 (46%)
		C2-set_2	135..225	CDD:285423	28/105 (27%)
		Ig_3	265..329	CDD:290638	17/73 (23%)
		I-set	346..420	CDD:254352	25/74 (34%)
		Ig	360..425	CDD:299845	22/88 (25%)
		Ig5_KIRREL3-like	428..524	CDD:143235	19/96 (20%)
		IG_like	435..524	CDD:214653	16/88 (18%)
sns	NP_001036532.1	I-set	73..170	CDD:254352	41/98 (42%)
		Ig	76..155	CDD:299845	34/78 (44%)
		IG_like	186..279	CDD:214653	29/104 (28%)
		Ig	197..279	CDD:299845	28/93 (30%)
		IG_like	296..376	CDD:214653	16/80 (20%)
		Ig	300..361	CDD:299845	15/61 (25%)
		Ig	380..454	CDD:299845	25/78 (32%)
		IG_like	490..573	CDD:214653	18/105 (17%)
		Ig	501..560	CDD:299845	12/70 (17%)
		Ig	584..666	CDD:299845	14/91 (15%)
		IG_like	585..666	CDD:214653	14/90 (16%)
		I-set	678..767	CDD:254352	22/116 (19%)
		IGc2	692..757	CDD:197706	16/81 (20%)
		Ig	788..849	CDD:143165	1/2 (50%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950