DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and DIP-gamma

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	84/387 - (21%)
Similarity:	132/387 - (34%)	Gaps:	107/387 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLATIVGMVRSSPYTSYQNQRF----AMEPQDQ--------TAVVGARVTLPCRV----INKQ 55
            :|::||..|.      .|.|||..    .::|..:        |...|....|.|.|    .||.
  Fly    12 ILIMATKCGS------GSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKV 70

  Fly    56 GTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIR 120
            |.|:.:.........|.::...|.:::..|.. .:.|.|..:...|...|.||::..|     ::
  Fly    71 GWLRASDQTVLALQGRVVTHNARISVMHQDMH-TWKLKISKLRESDRGCYMCQINTSP-----MK 129

  Fly   121 STFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITW--IDGLGNVLTDNIEYT 183
            .....:.|.|||:.........:...|.....:.|.:. |.|...:||  .||         |..
  Fly   130 KQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKAT-GNPQPRVTWRREDG---------EMI 184

  Fly   184 VIPLPDQRRFTA-----KSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKV-- 241
            :|..|..|....     .|.|||...:......:.|.|.|...... |.::.:.|::||.|:.
  Fly   185 LIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAV-SKRVSLSVQFAPMVRAPS 248

  Fly   242 NVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWF----------- 295
            .::|:..|                         |.|:|||:.:|:||.|.| |.
  Fly   249 QLLGTPLG-------------------------SDVQLECQVEASPSPVSY-WLKGARTSNGFAS 287

  Fly   296 ----------INDEPIIGGQK---TEM------VIRNVTRKFHDAIV---KCEVQNSVGKSE 335
                      ...|.::.|.|   ||.      |:..|.|.|..:.|   .|...||:|::|
  Fly   288 VSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAE 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	21/107 (20%)
		Ig	42..114	CDD:299845	17/75 (23%)
		C2-set_2	135..225	CDD:285423	19/96 (20%)
		Ig_3	265..329	CDD:290638	22/96 (23%)
		I-set	346..420	CDD:254352
		Ig	360..425	CDD:299845
		Ig5_KIRREL3-like	428..524	CDD:143235
		IG_like	435..524	CDD:214653
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	20/97 (21%)
		Ig	47..129	CDD:299845	19/87 (22%)
		Ig	140..238	CDD:299845	22/108 (20%)
		IG_like	247..355	CDD:214653	28/129 (22%)
		Ig	256..351	CDD:299845	27/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810