DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and side

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	201/976 - (20%)
Similarity:	312/976 - (31%)	Gaps:	367/976 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AVVGARVTLPCRVI-----NKQGTLQWTKDDFGLGT-SRDLSG----FERYAMVGS--------- 84
            |.:|..|.|||.:.     :....|.|.||..|:.. |.|..|    ...:|.:.|
  Fly   102 AALGKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFS 166

  Fly    85 --DEEGDYSLDIYPVMLDDDARYQCQV----SPGPEGQPAIRSTFAGLTVLVPPEAPKI------ 137
              |...|..|.|..|..:|...|:|:|    ||       .|:....||::||||.|:|
  Fly   167 IGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSP-------TRNFRHNLTLVVPPEEPRIFDAQGK 224

  Fly   138 ----------------------------------------------------------------- 137

  Fly   225 EISQMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTTR 289

  Fly   138 ----------TQG---------DV---IY--------------ATEDRKVEIECVSVGGKPAAEI 166
                      .||         ||   :|              .|..:.:.|.|.|.|..|||:|
  Fly   290 DFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKI 354

  Fly   167 TWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNT--ADRTYRSAKI 229
            ||:  |......|.|.||....:....|. |:|.|....|:.|...:|:|.|.  :.......:|
  Fly   355 TWL--LDGEPIRNAEVTVHSDKEDGNITT-SILTLKVTSENDNAELTCRATNPWFSGGAIEDKRI 416

  Fly   230 RVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIV---EHSQVRLECRADANPSDVR 291
             :.|.|.|.|.|::....|                    ||:|   |...|..:|||||.|....
  Fly   417 -IRVAYPPTVSVHLANEDP--------------------SRLVTRAEGQNVTFKCRADARPPVTS 460

  Fly   292 YRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSE-TLDISYAPSFRQRPQSM 355
            |.||.|... :.|:.||::......:.......|...|:.|::..|. ||.:.::|  |.:..:.
  Fly   461 YSWFKNGMR-MSGESTEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQFSP--RCKSGTE 522

  Fly   356 EADVGSV----VSLTCEVDSNPQPEIV---WIQHPSDRVV----------GTSTNLTF------- 396
            :..:|:|    :.:.||||::| |:.|   |..:.:..|.          |.::.:|:
  Fly   523 QTSIGAVSLHSILVKCEVDADP-PDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSE 586

  Fly   397 -----------------------------------SVSNETAGRYYCKANVPG------YAEISA 420
                                               .:.|:|.....|.|...|      ..|:..
  Fly   587 LITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRNDTVLEVVCVAGSDGGLSQYFMLEVVG 651

  Fly   421 DAYVYLKGSP--AIGSQRTQY----GLVGDT--ARIECFASSVPRARHVSWTFNGQEISS----- 472
            ...:| .|.|  :.|..|.|:    || ||.  :.:...|:|.|       .|..||.|.
  Fly   652 GDPLY-SGDPGGSAGQGRGQFSEAIGL-GDNEISTLNDQATSAP-------IFRMQENSPQFRLN 707

  Fly   473 --ESGHDYSILVDAV--PGGVKSTLIIRDSQ-AYHYGKYNCTVVND------------------- 513
              |.|.:|..||.||  .|..:..::|.:.: |...|.|:.:::::
  Fly   708 NLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVGGSG 772

  Fly   514 ----YGNDVAEIQLQAKKSVSLLM--TIVGGISVVAFLLVLTILVVVYIKCKKRTKLP-PADVIS 571
                .|...:......|:|..|::  .:|.|..||..::|..|:||    |:.|.:.| |.:|..
  Fly   773 SSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVV----CRHRPRPPEPQEVRK 833

  Fly   572 EHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIM 636
            ..:..:|...|..:|..:..      :::..||..  .|.....:||..:|  |    .|..
  Fly   834 SMRPARNDVPSMYIEEDELN------ELEEGGGRA--ADIRARVAPPNSHL--C----GGGG--- 881

  Fly   637 QNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGL----PSLQ 697
                                       :||.....||||::.| :.|......::.:    |||.
  Fly   882 ---------------------------MPMPGGVGSSGGAIVG-VAGPHHYISESFIQYAQPSLN 918

  Fly   698 STT---ASVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVDPRYSAIYGNPYLRSSNSSLLP 759
            ...   ..|.||.|   ||..||.::.     |:......|..||            :|.::..|
  Fly   919 GDVLLPLLVTSSQP---CSTNSTISSV-----VLAMPQAKLCPDP------------ASRNTAWP 963

  Fly   760 P 760
            |
  Fly   964 P 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	30/115 (26%)
		Ig	42..114	CDD:299845	26/96 (27%)
		C2-set_2	135..225	CDD:285423	32/198 (16%)
		Ig_3	265..329	CDD:290638	19/66 (29%)
		I-set	346..420	CDD:254352	21/138 (15%)
		Ig	360..425	CDD:299845	19/129 (15%)
		Ig5_KIRREL3-like	428..524	CDD:143235	29/136 (21%)
		IG_like	435..524	CDD:214653	26/127 (20%)
side	NP_001247334.1	V-set	95..211	CDD:284989	30/115 (26%)
		IG_like	100..211	CDD:214653	30/115 (26%)
		Ig	235..301	CDD:299845	0/65 (0%)
		Ig	326..408	CDD:299845	25/84 (30%)
		IG_like	329..407	CDD:214653	25/80 (31%)
		IG_like	435..511	CDD:214653	24/76 (32%)
		Ig_2	442..511	CDD:290606	21/69 (30%)
		FN3	<700..735	CDD:238020	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910