DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and dscamb

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	804	Identity:	169/804 - (21%)
Similarity:	268/804 - (33%)	Gaps:	257/804 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SSPYTSYQ---NQR--FAMEP-QDQTAVVGARVTLPCRVIN-KQGTLQWTKDDFGLGTSRDLSGF 76
            |:...|||   |.|  .::.| ::.||:.|....:.||:|. ...:::|.||...|..:.....|
Zfish   489 SAGSVSYQARINVRGPASIRPMKNVTAIAGRDTYIHCRIIGYPYYSIKWYKDSNLLPFNHRQRAF 553

  Fly    77 ERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGD 141
                      |.:.:|.:..|...|:..|.|.|...||.| ..||..  :||.||   |.|...|
Zfish   554 ----------ENNGTLKLSNVQNSDEGEYTCYVLVDPEKQ-IHRSVH--VTVKVP---PLIQHSD 602

  Fly   142 VIYATEDRKVEIECVSVGGKPAAEITW------IDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLR 200
            ...|:..::|.|.||.:.|.....|||      |:....|..|||::|             |.||
Zfish   603 SQSASIGQRVFIPCVVISGDLPMSITWHKDGRPINASLGVTIDNIDFT-------------SSLR 654

  Fly   201 LTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHM 265
            ::...|.||.:::|.|:|.|
Zfish   655 ISNLSEIHNGSYTCIARNEA--------------------------------------------- 674

  Fly   266 STGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNS 330
                ..||||                                                   :|
Zfish   675 ----AAVEHS---------------------------------------------------IQ-- 682

  Fly   331 VGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQH------PSDRVVG 389
                     |.:...|.|..:|:..:...|..|:|.|....||.|.||| .|      |..:.:.
Zfish   683 ---------LIVKVPPHFEVQPKDQDGIYGKSVTLNCSAKGNPIPTIVW-NHSKGAGVPQFQPIA 737

  Fly   390 TSTN-----------LTFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGS-QRTQYGLV 442
            .::.           |...|..|.||.|.||.:....|:||...|:.:|....|.| ..|.....
Zfish   738 LNSGSRVQLLENGSLLIKHVLEEDAGFYLCKVSNDVGADISKSMYLTVKIPAMITSYPNTTRAEQ 802

  Fly   443 GDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYN 507
            |....:.|.|.. .:...|.|......|:.:... |.:.|..|...|.|||.|..:.....|.::
Zfish   803 GHMTEMSCTAHG-EKPIKVRWEKESHIINPDMSR-YVVTVKEVGDEVISTLQILHTVREDSGFFS 865

  Fly   508 CTVVNDYGNDVAEIQLQAK---------------KSVSLLMTI--VGGISVVAFLLVLTILVVVY 555
            |..:|.||.|...|||..:               ::::|..|:  .|...:..:          .
Zfish   866 CIAINSYGEDKGIIQLIVQDRPDPPEVEIREVKDRTIALRWTMGFDGNSPITGY----------D 920

  Fly   556 IKCKKRT--------------KLPPADVISEHQI-TKNGGVSCKLEPGD-RTSNYSDLKVDISGG 604
            |..|.::              :|..|.:|..|.. |.|..:..|.:.|: |.||  :|.:
Zfish   921 INYKNKSASWASSQMTKDVSPQLNQATIIELHPASTYNIRMFAKNQIGESRPSN--ELTI----- 978

  Fly   605 YVPYGDYSTHYSPP---PQYLTTCSTKSNGSSTIMQNNHQN-QLQLQQQQQQSHHQHHTQTTTLP 665
                   :|..:||   ||.:...:..|.|.....:..|:: |..|.:..|..:.:..|..:...
Zfish   979 -------TTDEAPPDGAPQDVQLEAISSQGIKVTWKPPHKHLQNGLIRSYQVCYREFGTGGSPQY 1036

  Fly   666 MTFLTNSSGGSLTGSIIGSREIRQDN---------GL-PSLQSTTASVVSSSPNGSCSNQSTTAA 720
            .|...:::|...|.::...::..|..         |: |:.:..|.:.:...|:....|..|||.
Zfish  1037 NTINVDTTGDIETLTLDNLKKYTQYEVRVQAANRAGMGPTSEEITITTLEDVPSRPPENVVTTAT 1101

  Fly   721 TTTTTHVVVPSSMALSVDPRYSAI 744
            |        |.:::||    :||:
Zfish  1102 T--------PETISLS----WSAL 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	26/97 (27%)
		Ig	42..114	CDD:299845	16/72 (22%)
		C2-set_2	135..225	CDD:285423	28/95 (29%)
		Ig_3	265..329	CDD:290638	4/63 (6%)
		I-set	346..420	CDD:254352	25/90 (28%)
		Ig	360..425	CDD:299845	24/81 (30%)
		Ig5_KIRREL3-like	428..524	CDD:143235	25/96 (26%)
		IG_like	435..524	CDD:214653	23/88 (26%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352
		I-set	225..310	CDD:254352
		IGc2	239..300	CDD:197706
		IG_like	320..400	CDD:214653
		IGc2	328..391	CDD:197706
		IG_like	417..501	CDD:214653	4/11 (36%)
		Ig	424..498	CDD:143165	4/8 (50%)
		IG_like	511..592	CDD:214653	23/93 (25%)
		IGc2	518..576	CDD:197706	15/67 (22%)
		I-set	595..685	CDD:254352	35/216 (16%)
		Ig	612..682	CDD:143165	28/182 (15%)
		I-set	689..785	CDD:254352	27/96 (28%)
		Ig7_DSCAM	706..785	CDD:143211	23/79 (29%)
		IG_like	795..883	CDD:214653	24/89 (27%)
		Ig	803..890	CDD:299845	23/88 (26%)
		FN3	887..980	CDD:238020	17/116 (15%)
		FN3	987..1084	CDD:238020	16/96 (17%)
		FN3	1092..1185	CDD:238020	10/34 (29%)
		FN3	1190..1279	CDD:238020
		IGc2	1302..1367	CDD:197706
		FN3	1398..1471	CDD:238020
		FN3	1485..1557	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810