DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and wrapper

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	99/470 - (21%)
Similarity:	185/470 - (39%)	Gaps:	89/470 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 TGSRIVEHSQVRLECRADANPSDVRY-RWFINDEPIIGGQKTE--------------MVIRNV-- 314
            |..:..|:..|:|.|..:   :..|| ||..:|..::..:..|              :.:.||
  Fly    42 TTVKTYENDTVQLPCTLN---TPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQS 103

  Fly   315 --TRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSM-EADVGSVVSLTCEVDSNPQPE 376
              |..::     ||:.:..|.......:::..||.....|..: |..:|::..:.||....|||.
  Fly   104 SDTGDYY-----CEMNSDSGHVVQQHAIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPV 163

  Fly   377 IVW------IQHPSDRVVGTSTNLTFSV-SNETAGRYYCKANVPGYAEIS-ADAYVYLKGSPAIG 433
            |.|      ||..|:  .|...:|...: |...||...|.|: .|..|.: |:.|:::..||.:.
  Fly   164 ITWRLNGNVIQPQSN--TGNRQSLILEIKSRNQAGLIECVAS-NGVGEPAVANVYLHVLFSPEVS 225

  Fly   434 -SQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEI-------SSESGHDYSILVDAVPGGVK 490
             .|...|..:|..|.:||...:.|.|. |.|..:|..:       :.||....:..||.....|:
  Fly   226 IPQPVVYTKLGSRAHLECIVEAAPAAT-VKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVR 289

  Fly   491 STLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVL---TILV 552
            ..|:::..:....|:|.|...|........::|..:....|.....|..|..:.:||.   ::|.
  Fly   290 HMLVVKSVRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQTESLLP 354

  Fly   553 VVYIKCKKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKV--DISGGYVPYGDYSTH- 614
            ::..|.|.| ::|..:|..:.:                 :|:::|.:  ..:.|.:....|:.|
  Fly   355 IMEFKLKFR-QIPSNNVTRQVR-----------------TNWTELTIPAQATNGLIYITTYTLHG 401

  Fly   615 YSPPPQY-LTTCSTKSNG---SSTIMQ---------NNHQNQLQLQQQ--QQQSHHQHHTQTTTL 664
            ..|...| ::..:..|.|   :|.|::         .|:..:.:||..  ::..|::...::..|
  Fly   402 LQPASLYEVSVLARNSFGWSDNSKIVRFATGGEVELPNYSTESELQDDFTEEDFHNEITQRSEVL 466

  Fly   665 PMTFLTNSSGGSLTG 679
            ..:.:.||  ||:.|
  Fly   467 SASMMFNS--GSVNG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653
		Ig	42..114	CDD:299845
		C2-set_2	135..225	CDD:285423
		Ig_3	265..329	CDD:290638	16/80 (20%)
		I-set	346..420	CDD:254352	23/82 (28%)
		Ig	360..425	CDD:299845	22/72 (31%)
		Ig5_KIRREL3-like	428..524	CDD:143235	23/103 (22%)
		IG_like	435..524	CDD:214653	21/95 (22%)
wrapper	NP_477404.1	Ig	41..124	CDD:299845	17/89 (19%)
		IG_like	41..118	CDD:214653	16/83 (19%)
		IG_like	145..218	CDD:214653	22/75 (29%)
		Ig	147..219	CDD:299845	22/74 (30%)
		I-set	224..323	CDD:254352	21/99 (21%)
		IGc2	236..314	CDD:197706	19/78 (24%)
		FN3	339..431	CDD:238020	20/109 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810