DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and side-VIII

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	994	Identity:	202/994 - (20%)
Similarity:	322/994 - (32%)	Gaps:	325/994 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLATIVG------MVR-SSPYTSYQNQR--------FAMEPQDQTAVVGARVTLPCRVI---- 52
            ||:|:.:.|      .|| ||..|..:|..        .|..|....:::|....|||.|.
  Fly    15 LLVLSALNGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPPVLSESIMGTVGRLPCNVTPPIY 79

  Fly    53 -NKQGTLQW-------------TKD-DFGLGTS-RDLSGFERYAMVGSDEEGDYSLDIYPVMLDD 101
             ::...:.|             |:| :|..||. .|.:..||.:.......|  :|.|.....||
  Fly    80 EDRVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSFHVEGRAG--TLTIKSTTEDD 142

  Fly   102 DARYQCQV----SPGPEGQPAIRSTFAGLTVLVPPEAPKI--TQGDVI-------YATEDRKVEI 153
            ...|:|:|    ||       .|::...|||::|||:..|  ::|..|       | .|...:.|
  Fly   143 TGEYRCRVDFQKSP-------TRNSKVNLTVIIPPESVIILDSKGVTIEDHTLGPY-NEGSGINI 199

  Fly   154 ECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQN 218
            .||::||:|...:||:.  ||.:..|..... ||.::|.....|:.||..:..|  ...:|:|:|
  Fly   200 TCVAIGGRPQPRVTWLH--GNTVYKNASVGQ-PLSERRVGNTLSLARLERRNLH--MQLTCRAEN 259

  Fly   219 -------------------------------TADRTYRSAKIRVEVKYAPKV---KVNVMGSLP- 248
                                           :|..:|:.:.:.:..:.||.:   |    ||.|
  Fly   260 NNLTTPIISSVVLDMNLRPLIVKLQGENRALSAGNSYQLSCVVIGARPAPTITWWK----GSTPM 320

  Fly   249 ----------GGAGGSV-------------------------GGAGGG-----------SVHMST 267
                      |....||                         .|...|           |:.:.|
  Fly   321 KNTHEIATPDGNLTTSVLTFTPTIDDRGKFLSCRAEQSMIPESGMEDGWKLDIYHIPVVSLELGT 385

  Fly   268 ---GSRIVEHSQVRLECRADANPSDVRYRW-----FINDEPI--IGGQKTEMVIRNVTRKFHDAI 322
               .|.:.|...|..||...:||......|     .:.:.|.  |......:|::|.:|. ...|
  Fly   386 NSLNSTLREGIDVFFECNIKSNPWIYEVSWRHNGKILTNNPAEGIAVSNQSLVLQNASRA-RSGI 449

  Fly   323 VKCEVQNSVGKSEDSET-LDISYAPSFRQRPQ-SMEADVGSVVSLTCEVDSNP-QPEIVW----- 379
            ..|...|..|..|.:.. |||.:||..|.|.: |..:.....|.:.||:|:|| :...||
  Fly   450 YTCVGSNREGDGESNPVQLDIRFAPVCRPRQRLSYSSGRHETVKVACEIDANPAEATYVWKFNAT 514

  Fly   380 ----IQHPSDRVV------------------GT----STN----------------------LTF 396
                :..|:.:|.                  ||    :||                      |..
  Fly   515 QGETVDIPASQVAVDRGRSIAHYTPMTENDYGTLLCWATNEIGDQSEPCVYTIFPAGEPDPLLNC 579

  Fly   397 SVSNETAGRYY--CKANVPGYAEISADAYVYLKGS---PAIGSQRTQY----GLV---------- 442
            :|.|:|:..:.  |.....|..:......||:.|:   |.|...:..|    |||
  Fly   580 TVLNQTSTGFQIECIEGFNGGLQQDFIMEVYMNGTTRHPKISKSKRPYFEVSGLVPGMGYNVFLI 644

  Fly   443 -------GDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQA 500
                   .:...::.:....|..:.|..||.    .|..|...:...........|..:..:.:.
  Fly   645 ANNSKGRSNATILQVYTLKDPEKQTVKITFT----KSFQGLRPAYTKTKATATTTSDCVCDEDEF 705

  Fly   501 YHYGKYNCTVVNDYGNDV----------AEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVY 555
            .:.||   .:.:|.|.|.          |.:....:..:.:|..|||.|    ||:.|.|::||.
  Fly   706 LNLGK---GISHDEGTDADQQEDLSLAYAPVIEDIRPFLGILAGIVGSI----FLVALIIVIVVR 763

  Fly   556 IK---CKKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSP 617
            ::   .:.|...       .|..:..|||.   ..|..|.|.|.:    .||....|.
  Fly   764 VRGSSGRDRNNY-------SHPGSGVGGVG---GVGGTTGNGSGM----GGGGGGVGG------- 807

  Fly   618 PPQYLTTCSTKSNGSSTIMQNNHQNQLQL----QQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLT 678
                 ||.:  .|||..::.:|:...|.:    ....|.....|.....|..:|        |..
  Fly   808 -----TTAN--GNGSLGLLASNNNGSLVIGTLGHNGGQSVQDMHRIGRETCHVT--------SSL 857

  Fly   679 GSIIGSRE-IRQDNGLPSLQSTTASVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVDPRYS 742
            .||..:.: |.||......:.||.....:....:.:.|:....:.|..|::          |.|:
  Fly   858 DSIDKNPDIIPQDGHDLDDEWTTKGHGRTYATAAMAEQNAVITSGTYDHLM----------PTYA 912

  Fly   743 AIYGNPYLRSSNSSLLPPP 761
            .:         :....|||
  Fly   913 VV---------DKKTAPPP 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	29/119 (24%)
		Ig	42..114	CDD:299845	24/95 (25%)
		C2-set_2	135..225	CDD:285423	27/129 (21%)
		Ig_3	265..329	CDD:290638	16/73 (22%)
		I-set	346..420	CDD:254352	24/130 (18%)
		Ig	360..425	CDD:299845	20/120 (17%)
		Ig5_KIRREL3-like	428..524	CDD:143235	20/129 (16%)
		IG_like	435..524	CDD:214653	17/119 (14%)
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	27/119 (23%)
		IG_like	60..166	CDD:214653	26/114 (23%)
		Ig	182..266	CDD:299845	24/89 (27%)
		Ig	296..373	CDD:299845	12/80 (15%)
		IG_like	389..464	CDD:214653	18/75 (24%)
		IGc2	394..459	CDD:197706	15/65 (23%)
		Ig_3	490..554	CDD:290638	12/63 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910