DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and DIP-eta

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	89/452 - (19%)
Similarity:	163/452 - (36%)	Gaps:	128/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RFAMEPQDQTAVVGARVTLPCRVINKQG--TLQWTKDDFGLGTSRDLSGFERYAM-------VGS 84
            :|:....:.||.||....|.| |:...|  .:.|.:.|     ::.:...:.:.:       :.:
  Fly    44 KFSSPIVNMTAPVGRDAFLTC-VVQDLGPYKVAWLRVD-----TQTILTIQNHVITKNQRIGIAN 102

  Fly    85 DEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDR 149
            .|...:::.|..:...|...|.||::..|     ::|....|.|:|||:.........:...|..
  Fly   103 SEHKTWTMRIKDIKESDKGWYMCQINTDP-----MKSQMGYLDVVVPPDILDYPTSTDMVVREGS 162

  Fly   150 KVEIECVSVGGKPAAEITWIDGLG---NVLTD----NIEYTVIPLPDQRRFTAKSVLRLTPKKEH 207
            .|.::|.:. |.|...|||....|   .:.|.    :||.|.:.:|:.||              |
  Fly   163 NVTLKCAAT-GSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRR--------------H 212

  Fly   208 HNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIV 272
            |...:.|.|.|....:. |.:|.:.|.:.|  .:.|...|.|.                     |
  Fly   213 HMGAYLCIASNGVPPSV-SKRITLVVHFPP--MITVQNQLIGA---------------------V 253

  Fly   273 EHSQVRLECRADANPSDVRYRW-------------FINDEPIIGGQKTEMVIR-NVTRKFHDAIV 323
            |...|.|:|.::|.|..:.| |             :..:...|||.:..|.:. |...:......
  Fly   254 EGKGVTLDCESEAYPKSINY-WTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSY 317

  Fly   324 KCEVQNSVGKSEDSETL------DISYAPSF------RQRPQSMEADVGSVVSLTCEVDSNPQPE 376
            :|..:||:|.::.:..|      .::|..:|      ::|.:|.|:
  Fly   318 RCVAKNSLGDTDGTIKLYRIPPNAVNYVENFEARHKGKKRTKSSES------------------- 363

  Fly   377 IVWIQHPSDRVVGTSTNLTFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQ 438
                .||:.....:..::      |..|:.  ||::    .:.|::...:.|:.|.||:|.|
  Fly   364 ----HHPARAQEHSGEDM------ENPGKR--KADL----SLGAESIDSIYGNSAAGSRRRQ 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	20/104 (19%)
		Ig	42..114	CDD:299845	13/80 (16%)
		C2-set_2	135..225	CDD:285423	21/96 (22%)
		Ig_3	265..329	CDD:290638	15/77 (19%)
		I-set	346..420	CDD:254352	10/79 (13%)
		Ig	360..425	CDD:299845	7/64 (11%)
		Ig5_KIRREL3-like	428..524	CDD:143235	6/11 (55%)
		IG_like	435..524	CDD:214653	2/4 (50%)
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	19/100 (19%)
		IG_like	51..137	CDD:214653	18/96 (19%)
		IG_like	153..237	CDD:214653	23/99 (23%)
		Ig	161..224	CDD:299845	19/77 (25%)
		IG_like	252..335	CDD:214653	18/104 (17%)
		Ig	258..333	CDD:143165	16/75 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810