DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and DIP-kappa

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	108/522 - (20%)
Similarity:	180/522 - (34%)	Gaps:	116/522 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQD----------QTAVVGARVTLPCRVINKQG-T 57
            ||.:....|:..:.....:|....|:.|.|..|          .|..||....:.|.|.|.:| .
  Fly    40 TMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYK 104

  Fly    58 LQWTKDDFGLGTS---RDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAI 119
            :.|.:.|.....|   ..:|...|.::..:|....| |.|..|...|...|.|||:..|     :
  Fly   105 VAWVRVDTQTILSIHHNVISQNSRISLTYNDHRSWY-LHIKEVEETDRGWYMCQVNTDP-----M 163

  Fly   120 RSTFAGLTVLVPPEAPK-ITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYT 183
            ||....|.|:|||...: :|..|:: ..|.:.:.:.| ...|.|...:.|....|..:....|:.
  Fly   164 RSRKGYLQVVVPPIIVEGLTSNDMV-VREGQNISLVC-KARGYPEPYVMWRREDGEEMLIGGEHV 226

  Fly   184 VIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLP 248
            .:        ....:|.:|.....|...:.|.|.|....:. |.::.:.|::.|      |.|:|
  Fly   227 NV--------VDGELLHITKVSRLHMAAYLCVASNGVPPSI-SKRVHLRVQFPP------MLSIP 276

  Fly   249 GGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRW-------FINDEPIIGGQ- 305
            ....|:..|                 ..|.|||..:|.|:.:.| |       .|:|....|.:
  Fly   277 NQLEGAYLG-----------------QDVILECHTEAYPASINY-WTTERGDMIISDTSRAGDKY 323

  Fly   306 KTEMVIRNVTRKFHDAI----------VKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVG 360
            :|...:...|:.....|          .:|..:||:|:::.:..||        :.|....|.:.
  Fly   324 ETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLD--------EMPTPTTAIIS 380

  Fly   361 SVVSLTCEVD-----------SNPQPEI---VWIQHPSDRVVGTSTNLTFSVSNETAGRYYCKAN 411
            .:..|....|           :|..|:.   .|.........|.:.:     :|:|..|     |
  Fly   381 EMSLLNRSYDGKRRHRNKFDSANALPDYGVEEWRDGAQGNNAGNNGD-----NNQTPVR-----N 435

  Fly   412 VPGYAEISADAYVY--LKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVS--WTFNGQEISS 472
            .||....||.:...  |.....:|.:...:|:      .:..:||:|.|...|  |......:|:
  Fly   436 PPGAFHNSAGSLAQHNLLAKIMLGIKTQSFGI------FKRLSSSLPLAAGQSFLWLSTLSLVSA 494

  Fly   473 ES 474
            .|
  Fly   495 PS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	28/109 (26%)
		Ig	42..114	CDD:299845	20/75 (27%)
		C2-set_2	135..225	CDD:285423	15/90 (17%)
		Ig_3	265..329	CDD:290638	15/81 (19%)
		I-set	346..420	CDD:254352	14/87 (16%)
		Ig	360..425	CDD:299845	14/78 (18%)
		Ig5_KIRREL3-like	428..524	CDD:143235	10/49 (20%)
		IG_like	435..524	CDD:214653	9/42 (21%)
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	26/97 (27%)
		IG_like	82..174	CDD:214653	27/97 (28%)
		IG_like	184..267	CDD:214653	15/93 (16%)
		IGc2	191..255	CDD:197706	13/72 (18%)
		IG_like	282..368	CDD:214653	19/103 (18%)
		Ig	288..367	CDD:143165	18/79 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810