DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	105/458 - (22%)
Similarity:	175/458 - (38%)	Gaps:	105/458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHTMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQG-TLQWTKDD 64
            ::|.:.::.|...:|..:.....|..|...|         ||...|..|.|.:..| .:.|.|.|
  Fly    24 LIHLLLIVSLLEAIGAFQPEFVESISNVSVA---------VGRDATFTCHVRHLGGYRVGWLKAD 79

  Fly    65 FGLGTSRDLSGFERYAM-------VGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRST 122
                 ::.:.......:       |...::..::|.|..|..:|...|.||::..|     ::|.
  Fly    80 -----TKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDP-----MKSQ 134

  Fly   123 FAGLTVLVPPE-APKITQGDVIYATEDRKVEIECVSVGGKPAAEITW--IDGLGNVLTDNI-EYT 183
            ...|.|::||: ..:.|..||| ..|...|.:.| ...|.|...:||  .||...||.||: ..|
  Fly   135 IGFLDVVIPPDFISEDTSSDVI-VPEGSSVRLTC-RARGYPEPIVTWRREDGNEIVLKDNVGTKT 197

  Fly   184 VIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKV-NVMGSL 247
            :.|     .|..: ||:|:....:...::.|.|.|....:. |.:|.:.:.:.|.::| |.:...
  Fly   198 LAP-----SFRGE-VLKLSKISRNEMGSYLCIASNGVPPSV-SKRISLSIHFHPVIQVPNQLVGA 255

  Fly   248 PGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFIND--EPIIGGQK---- 306
            |.|                        :.|::||..:|:|..:.| | |.|  |.|:...|
  Fly   256 PLG------------------------TDVQIECHVEASPKSINY-W-IKDTGEMIVTSGKYHVQ 294

  Fly   307 --------TEMVIRNVTRKFHDAIV---KCEVQNSVGKSEDSETLDISYAPSFRQRP-------- 352
                    |:|.:  :.|||....|   :|..:||:|:.:.|..|.....|:..:.|
  Fly   295 ESSQSMYETKMSM--IVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPNRNKNPLNGGGKGG 357

  Fly   353 ---QSMEADVGSVVSLTCEVDSNPQPEIVWIQHPS----DRVVGTSTNLTFSVSNETAGRYYCKA 410
               .|::||...::....:|....|||...:|:.|    :...|....|| .:|...   ||...
  Fly   358 GAGGSLDADANDILKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLT-PLSPHV---YYTSG 418

  Fly   411 NVP 413
            |.|
  Fly   419 NKP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	21/103 (20%)
		Ig	42..114	CDD:299845	16/79 (20%)
		C2-set_2	135..225	CDD:285423	26/92 (28%)
		Ig_3	265..329	CDD:290638	19/80 (24%)
		I-set	346..420	CDD:254352	19/83 (23%)
		Ig	360..425	CDD:299845	14/58 (24%)
		Ig5_KIRREL3-like	428..524	CDD:143235
		IG_like	435..524	CDD:214653
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	19/93 (20%)
		Ig	51..131	CDD:299845	19/98 (19%)
		I-set	144..240	CDD:254352	29/104 (28%)
		IGc2	159..228	CDD:197706	22/75 (29%)
		Ig	244..337	CDD:299845	28/120 (23%)
		I-set	244..337	CDD:254352	28/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810