DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and Kirrel1

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_006232737.1	Gene:	Kirrel1 / 310695	RGDID:	727883	Length:	805	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	201/747 - (26%)
Similarity:	309/747 - (41%)	Gaps:	150/747 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLD 93
            ||:.||.|||.|.|.|..|||.::|..|.:|||||...||..:.|..:.||.:|||.:.|.|:|:
  Rat    54 RFSQEPADQTVVAGHRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLE 118

  Fly    94 IYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSV 158
            |....|.|||.|:||.:     :.|:||..|.||||:|||..:|..|.||.........:.|.:.
  Rat   119 ITDAELSDDASYECQAT-----EAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPYNLTCRAF 178

  Fly   159 GGKPAAEITWI-DGL---GNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNT 219
            ..||||.|.|. ||.   |.|.:..:      |.|.:|.|..|.|.:.|........|:|::.|.
  Rat   179 NAKPAATIIWFRDGTQQEGAVTSTEL------LKDGKRETTISQLLIQPTDLDIGRVFTCRSMNE 237

  Fly   220 ADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRAD 284
            |....:...|.::|.:.|.|.:                    |:...|   ::|..:|...|:|.
  Rat   238 AIPNGKETSIELDVHHPPTVTL--------------------SIEPQT---VLEGERVIFTCQAT 279

  Fly   285 ANPSDVRYRW----FINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYA 345
            |||..:.|||    |:.::......:|     ||...|....|.|||.|.||.:..|..:::.:|
  Rat   280 ANPEILGYRWAKGGFLIEDAHESRYET-----NVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFA 339

  Fly   346 PSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSD----------------RVVGTSTNL 394
            |.....|:....|:||.|:|||....||...:.|.:..|:                :|:..|..|
  Rat   340 PRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVLSNSNQL 404

  Fly   395 TF-SVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRA 458
            .. ||:...||.|.|:|.||.......:..:|:.|.|.|.|:..|:.:.||..::|||..|.|..
  Rat   405 LLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPP 469

  Fly   459 RHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRD-SQAYHYGKYNCTVVNDYGNDVAEIQ 522
            ..::|.:....:...:...|::.......||.|||.|.: .:|.....||||..|.:|...|.||
  Rat   470 DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQ 534

  Fly   523 LQAKKSVSLLMTIVGGISVVA-FLLVLTILVVVYIKCKKR---------TKLP-PADVISEHQIT 576
            |:.::  .|.:.|:.|.::.| .|||.:...:|:...::|         .||. ..:.::...:|
  Rat   535 LEERE--VLPVGIIAGATIGAGILLVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLT 597

  Fly   577 KNGGVSCKLEPGDRTSNYS-----------------DLKVDI----------------SGGY--- 605
            .:.      :..|.|::.|                 |||.|:                :.||
  Rat   598 MHS------DREDDTTSISTATRVMKAIYSSFKDDVDLKQDLHCDTIETREEYEMKDPTNGYYNV 656

  Fly   606 -----------VPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHT 659
                       |.|.||.   :|.|       |:.:|..:...::.....||....:.....:.|
  Rat   657 RAHEDRPSSRAVLYADYR---APGP-------TRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGT 711

  Fly   660 QTTTLPMTFLTNSSGGSLTGSIIGSREIRQDN 691
            :.|         .||.|..|....:.::..:|
  Rat   712 EPT---------PSGPSAPGGTDTTSQLSYEN 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	43/95 (45%)
		Ig	42..114	CDD:299845	31/71 (44%)
		C2-set_2	135..225	CDD:285423	26/93 (28%)
		Ig_3	265..329	CDD:290638	20/67 (30%)
		I-set	346..420	CDD:254352	25/90 (28%)
		Ig	360..425	CDD:299845	22/81 (27%)
		Ig5_KIRREL3-like	428..524	CDD:143235	30/96 (31%)
		IG_like	435..524	CDD:214653	26/89 (29%)
Kirrel1	XP_006232737.1	I-set	54..148	CDD:254352	44/98 (45%)
		Ig	57..148	CDD:299845	42/95 (44%)
		Ig2_KIRREL3-like	170..251	CDD:143236	23/86 (27%)
		I-set	255..336	CDD:254352	27/108 (25%)
		Ig_2	259..337	CDD:290606	25/105 (24%)
		Ig_2	340..437	CDD:290606	25/96 (26%)
		IG_like	346..437	CDD:214653	24/90 (27%)
		Ig5_KIRREL3	439..536	CDD:143306	30/96 (31%)
		IG_like	451..536	CDD:214653	25/84 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342408
Domainoid	1	1.000	87	1.000	Domainoid score	I7807
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10089
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8946
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.660