DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and ncam1a

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	931	Identity:	183/931 - (19%)
Similarity:	312/931 - (33%)	Gaps:	278/931 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VGARVTLPCRVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARY 105
            ||......|.|:.....:.|    |.....:.|.|....::..:||... :|.||...:|....|
Zfish    33 VGESKFFLCEVVGDAKEIDW----FAPNGEKLLPGRPDISISKTDESSS-TLTIYNANVDHAGMY 92

  Fly   106 QCQVSPG-PEGQ-PAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITW 168
            :|....| .|.| ..|...|..||....|...:..:||        ..:|.| .|...|...|.|
Zfish    93 KCVAKSGEKESQGTIIVKIFQKLTFQYAPSPQEFNEGD--------DADIIC-DVISSPPPTIIW 148

  Fly   169 IDGLGNVLTDNIEY---TVIPLPDQR-RFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKI 229
                        .|   .:.|..|.| :..:.:.|::...|:....:::|:.     |.....:|
Zfish   149 ------------RYKKMRIQPETDVRLKVLSNNHLQIRGIKKTDEGDYTCEG-----RIMARGEI 196

  Fly   230 RVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVE-------HSQVRLECRADANP 287
            .:.|   .||.|||:.|:                    .:|..|       :..|.|.|.||..|
Zfish   197 DLRV---IKVIVNVLPSI--------------------RTRYTELNATADINQAVTLACHADGYP 238

  Fly   288 SDVRYRWFINDEPIIGGQK-------TEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYA 345
             :...:|...:..:...:|       :|:.|::| .|..:...||..:|..|:..:..||::...
Zfish   239 -EPTVKWARGNTELESDEKYSLNEDGSELTIKDV-NKLDEGDYKCIARNKAGERSEEVTLNVFVQ 301

  Fly   346 PSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWI------------------QHPS--DRVVGT 390
            |..........:::...::||||...:|.|.|:|.                  :|.|  ..||..
Zfish   302 PKITFLENQTASELEEQITLTCEATGDPTPNIIWSFGRRVFTENEQASWTRPEKHKSLDGNVVVR 366

  Fly   391 S----TNLTFS-VSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIEC 450
            |    ::||.. |....||:|.|.|......:|.: .|:.::.:|.|...:..:...|:.|.|.|
Zfish   367 SDARVSSLTLKYVQFTDAGQYLCTARNSIGQDIQS-MYLEVRYAPKIQGPQAVFTWEGNPANITC 430

  Fly   451 FASSVPRARHVSWTFNGQEISSESGHDYSI-------LVDAVPGGVKSTLIIRDSQAYHYGKYNC 508
            .|.:.|.| .|.|..:||::.|.:..:..|       .::..|          ||| ..:|.|||
Zfish   431 EALAHPGA-SVLWFRDGQQLPSANTTNVKIYNTPTVSFLEVTP----------DSQ-NDFGSYNC 483

  Fly   509 TVVNDYGNDVAE-IQLQAK-------------KSVSLL----MTIVGGISVVAFLLV-------- 547
            |..|..|.:..| |.:||.             .|.:::    ....||:.|:.:...
Zfish   484 TATNVIGTESKEFILVQADVPSAPSIERVEPYSSTAMIEFEEPASSGGVPVLKYKAEWRIAGQDW 548

  Fly   548 ----------LTILVVVYIKCKKRTKLPPADVISEHQITKNGGVSCKLEP--------GDRTSNY 594
                      |.::.:|.:|.:...::..:.:..:.:...:...|.|.:|        .:..::.
Zfish   549 TDREYELEDGLNLITIVGLKPETTYEVKISAINGKGEGESSAPESFKTQPVRLPFRMSPETPTSI 613

  Fly   595 SDLKVDISGGYVP----------YGDYSTHY-------SPPPQYLTTCSTKS-----------NG 631
            .....||.|...|          ..:...|:       ||...||.....|:           :.
Zfish   614 PPTTADIKGEPNPPKLEAKPQSTGNEMKVHFIKQDDGGSPIKHYLVRYRAKNRQDWKPEIRMPDA 678

  Fly   632 SSTIMQN----NHQNQLQLQQQQQQSHHQHHTQT-TTLP-MTFLTNSSGGSLTGSIIG------- 683
            |..|:..    |.:.::.:..:.|:...:..|.: .||| .|.:..:|.|..||:|:|
Zfish   679 SDYIVLRGLDWNTEYEVYVIAENQRGRSEPGTLSFRTLPEPTAIPETSSGLGTGAIVGILIVVFI 743

  Fly   684 -----------------------------------SREIRQDNGLPSLQSTTASVV------SSS 707
                                               |::|.:.....:...:...:|      ..:
Zfish   744 LLLFGVDVTCYFLNKCGLLMCIAVNFCGKSGPSAKSKDIEEGKAAFTKDESKEPIVEVRTEEERT 808

  Fly   708 PN----GSCSNQSTT-------AATTTTTHV-VVPS-----------------SMALSVDPRYSA 743
            ||    |......||       ||.||.|.| ::||                 ::..|.||:.:.
Zfish   809 PNHEGGGPTEPNETTPLTDPEHAADTTATVVDLLPSVTTNSDPGTESPASDSTTLTTSTDPKPTP 873

  Fly   744 IYGNPYLRSSNSSLLPPPTAV 764
            ....|  :.|.:|...||.||
Zfish   874 QSSTP--KPSVTSPTSPPQAV 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	23/90 (26%)
		Ig	42..114	CDD:299845	16/72 (22%)
		C2-set_2	135..225	CDD:285423	16/93 (17%)
		Ig_3	265..329	CDD:290638	16/77 (21%)
		I-set	346..420	CDD:254352	23/98 (23%)
		Ig	360..425	CDD:299845	23/89 (26%)
		Ig5_KIRREL3-like	428..524	CDD:143235	28/103 (27%)
		IG_like	435..524	CDD:214653	26/96 (27%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	20/83 (24%)
		I-set	21..111	CDD:254352	20/82 (24%)
		IG_like	121..200	CDD:214653	18/104 (17%)
		IGc2	128..189	CDD:197706	15/86 (17%)
		Ig	208..301	CDD:299845	21/114 (18%)
		IG_like	219..298	CDD:214653	18/80 (23%)
		Ig	300..406	CDD:299845	24/106 (23%)
		IG_like	308..406	CDD:214653	23/98 (23%)
		ig	413..498	CDD:278476	25/96 (26%)
		IG_like	415..498	CDD:214653	25/94 (27%)
		fn3	505..589	CDD:278470	7/83 (8%)
		FN3	624..715	CDD:238020	12/90 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900