DRSC/TRiP Functional Genomics Resources

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Protein Alignment rst and Kirrel2

DIOPT Version :9

Sequence 1:NP_001284835.1 Gene:rst / 31290 FlyBaseID:FBgn0003285 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:674 Identity:181/674 - (26%)
Similarity:281/674 - (41%) Gaps:109/674 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLHTMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDF 65
            ||.:..|:.|....|...|||:       |..:|:|...::|....|||.:...:|.:|||||..
Mouse     1 MLASALLVFLCCFKGHAGSSPH-------FLQQPEDMVVLLGEEARLPCALGAYRGLVQWTKDGL 58

  Fly    66 GLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLV 130
            .||..|||.|:.||.:.|:...|.:.|.|.||.|:|:|.|:||.|     |..:||..|.|.|:|
Mouse    59 ALGGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQAS-----QAGLRSRPAQLHVMV 118

  Fly   131 PPEAPKITQGDVIYATEDRKVEIECVSVG-GKPAAEITWI-DGLGNVLTDNIEYTVIPLPDQRRF 193
            |||||::..|..:.........:.|.|.| .:||.|:.|. ||   :..|...:....|.|:...
Mouse   119 PPEAPQVLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDG---IRLDGSSFHQTTLKDKATG 180

  Fly   194 TAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGA 258
            |.::.|.|||..........|:|::.|..|.|...:.:.::|.|.|.::                
Mouse   181 TVENTLFLTPSSHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLS---------------- 229

  Fly   259 GGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIG--GQKTEMVIRNVTRKFHDA 321
                   :....:.|..:|...|:|.|.|....|||.....|::|  |.:.| |:.:.|  |...
Mouse   230 -------AEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE-VVADAT--FLTE 284

  Fly   322 IVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDR 386
            .|.|||.|:||.:..|..|::.|.|..:.:|:|:..|||...|.:|....||.|.|.|.:....:
Mouse   285 PVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRGNPLPRITWTRMGGSQ 349

  Fly   387 VVGTSTNLTF-SVSNETAGRYYCKANV--PGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARI 448
            |:.:...|.. ||:.|.||.|.|:|..  .|.....|.|.:.:...|.:.:.:.....:...||:
Mouse   350 VLSSGPTLRLPSVALEDAGDYVCRAEPRRTGLGGGKAQARLTVNAPPVVTALQPAPAFLRGPARL 414

  Fly   449 ECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPG---------GVKSTLIIRDSQAYHYG 504
            :|...:.|....|.|:::  |...|:|.....||:|.|.         |:.|.|.|..:|...:.
Mouse   415 QCVVFASPAPDSVVWSWD--EGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFT 477

  Fly   505 K-YNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVV-------YIKCKKR 561
            . :||:..|..|....:|.|..:..:..:..:.|..|....||::...||:       ..|.|..
Mouse   478 TGFNCSARNRLGEGRVQIHLGRRDLLPTVRIVAGAASAATSLLMVITGVVLCCWRHGSLSKQKNL 542

  Fly   562 TKLP----------------------------PADVISEHQITKNGGVSCKLEPGDRTSNY---S 595
            .::|                            .:|::.|.:..        ||..|.|:.|   .
Mouse   543 VRIPGSSEGSSSRGPEEETGSSEDRGPIVHTDHSDLVLEEKEA--------LETKDPTNGYYRVR 599

  Fly   596 DLKVDISGGYVPYGDYSTHYSPPP 619
            .:.|.:|.|..|.|..   :.|||
Mouse   600 GVSVSLSLGEAPGGGL---FLPPP 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rstNP_001284835.1 IG_like 34..130 CDD:214653 39/95 (41%)
Ig 42..114 CDD:299845 31/71 (44%)
C2-set_2 135..225 CDD:285423 23/91 (25%)
Ig_3 265..329 CDD:290638 20/65 (31%)
I-set 346..420 CDD:254352 24/76 (32%)
Ig 360..425 CDD:299845 21/67 (31%)
Ig5_KIRREL3-like 428..524 CDD:143235 24/105 (23%)
IG_like 435..524 CDD:214653 23/98 (23%)
Kirrel2NP_766486.1 IG 27..116 CDD:214652 38/93 (41%)
Ig 122..220 CDD:416386 25/100 (25%)
Ig strand A 123..126 CDD:409353 1/2 (50%)
Ig strand A' 129..133 CDD:409353 0/3 (0%)
Ig strand B 140..147 CDD:409353 2/6 (33%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 1/4 (25%)
Ig strand C' 161..163 CDD:409353 1/4 (25%)
Ig strand D 166..173 CDD:409353 0/6 (0%)
Ig strand E 180..188 CDD:409353 2/7 (29%)
Ig strand F 197..205 CDD:409353 2/7 (29%)
Ig strand G 211..217 CDD:409353 1/5 (20%)
Ig_3 223..292 CDD:404760 22/94 (23%)
Ig strand B 241..245 CDD:409353 1/3 (33%)
Ig strand C 255..259 CDD:409353 2/3 (67%)
Ig strand E 272..275 CDD:409353 1/3 (33%)
Ig strand F 281..290 CDD:409353 3/8 (38%)
Ig strand G 298..301 CDD:409353 0/2 (0%)
Ig 315..392 CDD:416386 25/76 (33%)
Ig strand A' 316..321 CDD:409353 1/4 (25%)
Ig strand B 324..333 CDD:409353 2/8 (25%)
Ig strand C 339..343 CDD:409353 1/3 (33%)
Ig strand C' 346..348 CDD:409353 0/1 (0%)
Ig strand D 351..354 CDD:409353 0/2 (0%)
Ig strand E 355..360 CDD:409353 1/4 (25%)
Ig strand F 368..376 CDD:409353 4/7 (57%)
Ig strand G 382..392 CDD:409353 2/9 (22%)
Ig 394..498 CDD:416386 24/105 (23%)
Ig strand A 395..399 CDD:409353 1/3 (33%)
Ig strand A' 401..404 CDD:409353 0/2 (0%)
Ig strand B 412..419 CDD:409353 3/6 (50%)
Ig strand C 426..431 CDD:409353 2/4 (50%)
Ig strand C' 433..436 CDD:409353 1/2 (50%)
Ig strand D 444..451 CDD:409353 3/6 (50%)
Ig strand E 461..468 CDD:409353 3/6 (50%)
Ig strand F 479..486 CDD:409353 2/6 (33%)
Ig strand G 489..496 CDD:409353 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576 1/33 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838626
Domainoid 1 1.000 87 1.000 Domainoid score I7972
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 259 1.000 Inparanoid score I3111
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 1 1.000 - - FOG0001084
OrthoInspector 1 1.000 - - mtm8709
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1593
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.760

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