DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_011240777.1	Gene:	Igsf9b / 235086	MGIID:	2685354	Length:	1443	Species:	Mus musculus

Alignment Length:	780	Identity:	154/780 - (19%)
Similarity:	247/780 - (31%)	Gaps:	219/780 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EPQDQTAVVGARVTLPCRVIN------KQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDY- 90
            ||:..||..|..|.|.|.||:      ....::|.|  ||:    .:..|.::.......:.:|
Mouse    31 EPEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFK--FGV----PIPIFIKFGYYPPHVDPEYA 89

  Fly    91 ---------SLDIYPVMLDDDARYQCQVSPGPEGQPAIRS-TFAGLTVLVPPEAPKITQGDVIYA 145
                     ||.:..|..:|...|:|:|....:......: ::..||:..||...: |....|.|
Mouse    90 GRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE-TPPQYIEA 153

  Fly   146 TEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNT 210
            .|...:.:.|.:. |.|...:||:.. |.:|..:.:|.|          :...|.:|........
Mouse   154 KEGGSITMTCTAF-GNPKPIVTWLKE-GTLLGASAKYQV----------SDGSLTVTSVSREDRG 206

  Fly   211 NFSCQAQNTADRTYRSAKIRVE-----VKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSR 270
            .::|:|.:.......:..:.|:     |.....:.||:
Mouse   207 AYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNI--------------------------- 244

  Fly   271 IVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTR--------KFHDA-IVKCE 326
               .....|.|||:|.|.::.|.|:..||.:......::.:|.:..        |..|| ...|.
Mouse   245 ---SQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCV 306

  Fly   327 VQNSVGKSED-SETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIV-WIQHPSDRVVG 389
            ..||:|:|.. |..|.:.|.......|..:...||....:.|.||:.|...:| |  :...|.:.
Mouse   307 PSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKW--NKDGRPLQ 369

  Fly   390 TSTNLTFSV-----------SNETAGRYYC-KANVPGYAEISADAYVYLKGSPAI----GSQRTQ 438
            ...||.:::           :.|..|.|.| ..|..|....||.|.:.||..|..    |.:..|
Mouse   370 VEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQ 434

  Fly   439 YGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHY 503
            .  .|....|.|.|:..| ...::|...|:  .|.|.|      :|:|.|   :|..|......:
Mouse   435 E--AGRELLIPCAAAGDP-FPVITWRKVGK--PSRSKH------NALPSG---SLQFRALSKEDH 485

  Fly   504 GKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPAD 568
            |::.|...|                            ||..:...|.|.|:      .|......
Mouse   486 GEWECVATN----------------------------VVTSITASTHLTVI------GTSPHAPG 516

  Fly   569 VISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSS 633
            .:..|.......||  .|||            ..|||..  .:|..|.|
Mouse   517 SVRVHVSMTTANVS--WEPG------------YDGGYEQ--TFSVWYGP---------------- 549

  Fly   634 TIMQNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPSLQS 698
                        |.::.|...|...:.:.....::|.                      :.||:.
Mouse   550 ------------LMKRAQFGPHDWLSLSVPPGPSWLL----------------------VDSLEP 580

  Fly   699 TTA---SVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVDPRYSAIYGNPYLRSSNSSLLPP 760
            .||   ||::.:..|:.:........|....|..|..:.|...||  .:..|...:....|.|||
Mouse   581 ETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVTPPR--CLTANRTQQGVLLSWLPP 643

Fly 761 760
Mouse 644 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	24/112 (21%)
		Ig	42..114	CDD:299845	19/87 (22%)
		C2-set_2	135..225	CDD:285423	17/89 (19%)
		Ig_3	265..329	CDD:290638	15/72 (21%)
		I-set	346..420	CDD:254352	18/86 (21%)
		Ig	360..425	CDD:299845	19/77 (25%)
		Ig5_KIRREL3-like	428..524	CDD:143235	21/99 (21%)
		IG_like	435..524	CDD:214653	19/88 (22%)
Igsf9b	XP_011240777.1	Ig	43..117	CDD:319273	17/79 (22%)
		I-set	141..227	CDD:369462	18/98 (18%)
		Ig	231..323	CDD:386229	24/121 (20%)
		Ig	<355..416	CDD:386229	14/62 (23%)
		Ig	440..504	CDD:319273	19/103 (18%)
		FN3	512..607	CDD:238020	23/160 (14%)
		FN3	623..705	CDD:238020	7/23 (30%)
		PHA03247	<900..1248	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900