DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and SDK1

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_689957.3	Gene:	SDK1 / 221935	HGNCID:	19307	Length:	2213	Species:	Homo sapiens

Alignment Length:	570	Identity:	112/570 - (19%)
Similarity:	183/570 - (32%)	Gaps:	202/570 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QLLLLATIV---------------GMVRSSPYTSYQNQR-----------FAMEPQDQTAVVG-A 43
            ||::|||..               |..::||:......|           ..:.|.:::.|.| :
Human   245 QLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSS 309

  Fly    44 RVTLPC----RVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDAR 104
            ..||.|    |.: :..::.|.::  |:..:..|..|.|...:.:....            |...
Human   310 ETTLECIASARPV-EDLSVTWKRN--GVRITSGLHSFGRRLTISNPTSA------------DTGP 359

  Fly   105 YQCQVS-PGPEGQPAIRSTFAGLTVLVPP---EAPKITQGDVIYATEDRKVEIECVSVGGKPAAE 165
            |.|:.: ||...:||..:.|  |.::.||   ..|:    ..|.|..:..|:|.|.::|
Human   360 YVCEAALPGSAFEPARATAF--LFIIEPPYFTAEPE----SRISAEVEETVDIGCQAMG------ 412

  Fly   166 ITWIDGLGNVLTDNIEYTVIPLPDQRRF-TAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKI 229
                               :|||..:.: .|.|:.||               ||
Human   413 -------------------VPLPTLQWYKDAISISRL---------------QN----------- 432

  Fly   230 RVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRW 294
                   |:.||...|.|                              |::   ...|.|
Human   433 -------PRYKVLASGGL------------------------------RIQ---KLRPED----- 452

  Fly   295 FINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDI-SYAPSFRQRPQSMEAD 358
                                     ..|.:|...|..|:.:....||: :.||.|.|||......
Human   453 -------------------------SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVT 492

  Fly   359 VGSVVSLTCEVDSNPQPEIVW-----------IQHPSDRVVGTSTNLTFSVSNETAGRYYC-KAN 411
            .|....|.|||...|:|.|.|           ::.|...::.:.......|..:.||.|.| .||
Human   493 DGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557

  Fly   412 VPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRA--RHVSWTFNGQEISSES 474
            ..|....||...|:.:.| .:........:.|.||.:.|.|:..||.  |:| |..:...::..|
Human   558 TEGSLNASATLTVWNRTS-IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV-WKKDNVALTPSS 620

  Fly   475 GHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQ 524
            .....:..|       .:|:|..:.:...|.|:|.:|::.|||....:|:
Human   621 TSRIVVEKD-------GSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLE 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	21/101 (21%)
		Ig	42..114	CDD:299845	15/77 (19%)
		C2-set_2	135..225	CDD:285423	16/90 (18%)
		Ig_3	265..329	CDD:290638	5/63 (8%)
		I-set	346..420	CDD:254352	23/85 (27%)
		Ig	360..425	CDD:299845	20/76 (26%)
		Ig5_KIRREL3-like	428..524	CDD:143235	22/97 (23%)
		IG_like	435..524	CDD:214653	21/90 (23%)
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		I-set	104..188	CDD:254352
		Ig	122..176	CDD:143165
		Ig	219..265	CDD:299845	5/19 (26%)
		IGc2	312..364	CDD:197706	12/66 (18%)
		I-set	386..475	CDD:254352	30/213 (14%)
		Ig	404..472	CDD:143165	25/188 (13%)
		I-set	480..570	CDD:254352	25/89 (28%)
		Ig	494..570	CDD:299845	20/75 (27%)
		I-set	575..664	CDD:254352	23/98 (23%)
		Ig	580..664	CDD:299845	22/92 (24%)
		FN3	668..759	CDD:238020
		fn3	771..857	CDD:278470
		FN3	872..967	CDD:238020
		FN3	972..1054	CDD:238020
		FN3	1070..1166	CDD:238020
		FN3	1176..1271	CDD:238020
		fn3	1279..1365	CDD:278470
		FN3	1378..1471	CDD:238020
		FN3	1477..1572	CDD:238020
		FN3	1580..1694	CDD:238020
		FN3	1704..1797	CDD:238020
		FN3	1802..1883	CDD:238020
		FN3	1903..1996	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2098
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2207..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900