DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and Iglon5

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001157990.1	Gene:	Iglon5 / 210094	MGIID:	2686277	Length:	336	Species:	Mus musculus

Alignment Length:	398	Identity:	83/398 - (20%)
Similarity:	136/398 - (34%)	Gaps:	115/398 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRV---------INKQGTL-- 58
            ::||..|.:.|:...|.....|:..|:....:.|...|...||.|.:         :|:...|
Mouse    10 LRLLAAAALAGLAVISRGLLSQSLEFSSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYA 74

  Fly    59 ---QWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIR 120
               :||.|.            ....::.:.||  :|:.|..|.|.|:..|.|...  ...||...
Mouse    75 GNDRWTSDP------------RVRLLINTPEE--FSILITQVGLGDEGLYTCSFQ--TRHQPYTT 123

  Fly   121 STFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVI 185
            ..:  |.|.||.....|:  ..:...|...|.:.|::| |:|...:||     ..|.|.
Mouse   124 QVY--LIVHVPARIVNIS--SPVAVNEGGNVNLLCLAV-GRPEPTVTW-----RQLRDG------ 172

  Fly   186 PLPDQRRFTAK-SVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPG 249
                   ||:: .:|.::..:......:.|...|..:....|.::.|.|.|.|.: .:|
Mouse   173 -------FTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTI-TDV------ 223

  Fly   250 GAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADA-NPSDVRYRWFINDEPIIGGQ------KT 307
                             |.:|........|.|.|.| .|:|  ::|:.:|..:..|.      :|
Mouse   224 -----------------TSARTALGRAALLRCEAMAVPPAD--FQWYKDDRLLSSGSAEGLKVQT 269

  Fly   308 E-----MVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTC 367
            |     ::..||:.: |.....|...|.:|.|..|..|         .||.|:|
Mouse   270 ERTRSMLLFANVSAR-HYGNYTCRAANRLGASSASMRL---------LRPGSLE----------- 313

  Fly   368 EVDSNPQP 375
              :|.|:|
Mouse   314 --NSAPRP 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	23/109 (21%)
		Ig	42..114	CDD:299845	18/85 (21%)
		C2-set_2	135..225	CDD:285423	16/90 (18%)
		Ig_3	265..329	CDD:290638	17/75 (23%)
		I-set	346..420	CDD:254352	7/30 (23%)
		Ig	360..425	CDD:299845	3/16 (19%)
		Ig5_KIRREL3-like	428..524	CDD:143235
		IG_like	435..524	CDD:214653
Iglon5	NP_001157990.1	Ig	41..129	CDD:416386	22/105 (21%)
		Ig strand A'	41..46	CDD:409353	1/4 (25%)
		Ig strand B	48..56	CDD:409353	3/7 (43%)
		CDR1	56..60	CDD:409353	0/3 (0%)
		FR2	61..68	CDD:409353	0/6 (0%)
		Ig strand C	61..67	CDD:409353	0/5 (0%)
		CDR2	69..79	CDD:409353	1/9 (11%)
		Ig strand C'	71..74	CDD:409353	1/2 (50%)
		Ig strand C'	76..79	CDD:409353	0/2 (0%)
		FR3	80..115	CDD:409353	11/48 (23%)
		Ig strand D	84..91	CDD:409353	0/6 (0%)
		Ig strand E	94..100	CDD:409353	2/7 (29%)
		Ig strand F	107..115	CDD:409353	2/7 (29%)
		CDR3	116..120	CDD:409353	0/3 (0%)
		Ig strand G	120..129	CDD:409353	2/10 (20%)
		FR4	122..129	CDD:409353	1/8 (13%)
		Ig strand A	132..137	CDD:409353	1/4 (25%)
		Ig_3	134..199	CDD:404760	15/85 (18%)
		Ig strand A'	140..145	CDD:409353	0/4 (0%)
		Ig strand B	148..157	CDD:409353	2/8 (25%)
		Ig strand C	163..167	CDD:409353	2/8 (25%)
		Ig strand D	174..177	CDD:409353	1/2 (50%)
		Ig strand E	178..183	CDD:409353	1/4 (25%)
		Ig strand F	191..199	CDD:409353	1/7 (14%)
		Ig_3	217..295	CDD:404760	19/104 (18%)
		putative Ig strand A	218..224	CDD:409353	2/29 (7%)
		Ig strand B	234..238	CDD:409353	1/3 (33%)
		Ig strand C	247..251	CDD:409353	1/5 (20%)
		Ig strand E	274..278	CDD:409353	0/3 (0%)
		Ig strand F	288..293	CDD:409353	1/4 (25%)
		Ig strand G	301..304	CDD:409353	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900