DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and Ncam1

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	966	Identity:	184/966 - (19%)
Similarity:	311/966 - (32%)	Gaps:	310/966 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VGARVTLPCRVINKQGTLQWTKDDF------GLGTSRDLSGF-----------ERYAMVGSDEEG 88
            :|..|:|...::..||.:...:..|      |....:|:|.|           :|.::|.:|::.
Mouse    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDS 78

  Fly    89 DYSLDIYPVMLDDDARYQCQVS--PGPEGQPAIR-STFAGLTVLVPPEAPKITQGDVIYATEDRK 150
            . :|.||...:||...|:|.|:  .|.:.:..:. ..|..|.....|...:..:|      ||
Mouse    79 S-TLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEG------ED-- 134

  Fly   151 VEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQ 215
            ..|.|..|...|...|....|...:|..::.:.|:         :.:.|::...|:.....:.|:
Mouse   135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL---------SNNYLQIRGIKKTDEGTYRCE 190

  Fly   216 AQNTADRTYRSAKIRVEVKYAPKVK-----VNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHS 275
            .:..|........|:|.|...|.|:     ||...:|            |.|
Mouse   191 GRILARGEINFKDIQVIVNVPPTVQARQSIVNATANL------------GQS------------- 230

  Fly   276 QVRLECRADANPSDVRYRWFINDEP-----------IIGGQKTEMVIRNVTRKFHDAIVKCEVQN 329
             |.|.|.||..| :....|..:.||           |.....:|:.||||. |..:|...|..:|
Mouse   231 -VTLVCDADGFP-EPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVD-KNDEAEYVCIAEN 292

  Fly   330 SVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTS--- 391
            ..|:.:.|..|.:...|...........::...|:||||...:|.|.|.|  ..|.|.:.:.
Mouse   293 KAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW--RTSTRNISSEEKA 355

  Fly   392 -----------------------TNLTF-SVSNETAGRYYCKA-NVPGYAEISADAYVYLKGSPA 431
                                   ::||. |:....||.|.|.| |..|  :.|...|:.::.:|.
Mouse   356 SWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPK 418

  Fly   432 IGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYS-ILVDAVPGGVKSTLII 495
            :......|...|:...|.|...:.|.|. :||..:||.:.|.   :|| |.:...|..  |.|.:
Mouse   419 LQGPVAVYTWEGNQVNITCEVFAYPSAT-ISWFRDGQLLPSS---NYSNIKIYNTPSA--SYLEV 477

  Fly   496 RDSQAYHYGKYNCTVVNDYGNDVAE---IQLQAKKSVSLLMT---------------IVGGISVV 542
            .......:|.||||.||..|.:..|   :|.....|.|:...               ..||:.::
Mouse   478 TPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPIL 542

  Fly   543 AFLL---------------------VLTILVVVYIKCKKR------------------------- 561
            .:..                     :..|:.::.:|.:.|
Mouse   543 KYKAEWKSLGEESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISAATEFKTQ 607

  Fly   562 --------------TKLP--------PADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDI--- 601
                          |.:|        |..|:....::|....:.||| |....:.:.:||::
Mouse   608 PVHSPPPLAPANSSTLVPLSPRATTWPLPVLPTTDLSKGEPSAPKLE-GQMGEDGNSIKVNLIKQ 671

  Fly   602 -SGGYVPYGDYSTHYSPPPQYLTTCSTK-----------SNGSSTIMQNN------HQNQLQLQQ 648
             .||           ||...||.....|           .:||..:|..:      ::..:..:.
Mouse   672 DDGG-----------SPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 725

  Fly   649 QQQQSHHQHHT-QTTTLPMTFLTNSS--GGSLTGSIIG--------------------------- 683
            ||.:|...|.. :|:..|.....|.|  .|..||:|:|
Mouse   726 QQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLM 790

  Fly   684 ---------------SREIRQDNGLPSLQSTTASVV------SSSPNGSCS-----NQST----- 717
                           .:::.:.....|...:...:|      ..:||....     |::|
Mouse   791 CIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEP 855

  Fly   718 --TAATTTTTHVVVPSSMAL-----SVDPRYSAIYGNPYLRSS--NSSLLPPPTAV 764
              .|.||.|...::||...:     ::...::....:|...::  .||:.||.|.|
Mouse   856 ELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNSPTSETTTLTSSIAPPATTV 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	24/108 (22%)
		Ig	42..114	CDD:299845	22/90 (24%)
		C2-set_2	135..225	CDD:285423	15/89 (17%)
		Ig_3	265..329	CDD:290638	18/74 (24%)
		I-set	346..420	CDD:254352	22/101 (22%)
		Ig	360..425	CDD:299845	23/92 (25%)
		Ig5_KIRREL3-like	428..524	CDD:143235	28/99 (28%)
		IG_like	435..524	CDD:214653	27/92 (29%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273	20/95 (21%)
		IG	124..190	CDD:214652	14/82 (17%)
		Ig3_NCAM-1_like	211..308	CDD:143207	29/124 (23%)
		Ig_NCAM-1	307..413	CDD:143277	24/109 (22%)
		Ig_3	417..494	CDD:372822	23/82 (28%)
		FN3	509..606	CDD:238020	7/96 (7%)
		fn3	649..731	CDD:365830	18/93 (19%)
		PHA03247	<905..1140	CDD:223021	4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900