DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rst and Dscam

DIOPT Version :9

Sequence 1:NP_001284835.1 Gene:rst / 31290 FlyBaseID:FBgn0003285 Length:764 Species:Drosophila melanogaster
Sequence 2:XP_038943864.1 Gene:Dscam / 171119 RGDID:619992 Length:2034 Species:Rattus norvegicus


Alignment Length:821 Identity:184/821 - (22%)
Similarity:291/821 - (35%) Gaps:181/821 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 SPYTSYQNQRFAMEPQDQTAVVGARV-----------TLPCRVIN-KQGTLQWTKDDFGLGTSR- 71
            |.:.|:.|. |:.||......|.|.:           .:||.... ...||:|.     |.|.. 
  Rat     7 SLFQSFANV-FSEEPHSSLYFVNASLQEVVFASTSGTLVPCPAAGIPPVTLRWY-----LATGEE 65

  Fly    72 --DLSGFERYAMVGSDEEGDYSLDIYPV------MLDDDARYQCQVSPGPEGQPAIRSTFAGL-T 127
              |:.|.......|       :|.|:|.      .|..|..|.| .:..|.|:  |||....: .
  Rat    66 IYDVPGIRHVHPNG-------TLQIFPFPPSSFSTLIHDNTYYC-TAENPSGK--IRSQDVHIKA 120

  Fly   128 VLVPP-----EAPKITQGDVIYATEDRKVEIECVSVGGKPA--AEITWIDGLGNVLTDNIEYTVI 185
            ||..|     |..|..:|:|        ...:|:......|  ..::|            |...:
  Rat   121 VLREPYTVRVEDQKTMRGNV--------AVFKCIIPSSVEAYVTVVSW------------EKDTV 165

  Fly   186 PLPDQRRFTAKSVLRLTPK---KEHHNTNFSCQAQN--TAD-RTYRSAKIRVEVKYAPKVKVNVM 244
            .|....||...|...|..|   .|....|:.|..::  |.: |...||::.|             
  Rat   166 SLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFV------------- 217

  Fly   245 GSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPI-IGG--QK 306
             |.|..:..|:   ..|..|    .:.:...:|.|.|:|..:| :..|||..::.|: :.|  ||
  Rat   218 -SDPANSAPSI---LDGFDH----RKAMAGQRVELPCKALGHP-EPDYRWLKDNMPLELSGRFQK 273

  Fly   307 --TEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEV 369
              |.::|.| :|........|||.|..|.::....|.:.........|:.:::.|||.|||:|.|
  Rat   274 TVTGLLIEN-SRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSV 337

  Fly   370 DSNPQPEIVW-----IQHPSDRVVGTSTN-----LTFSVSNETAGRYYCKANVPGYAEISADAYV 424
            ..|...|:.|     |.:|...|..|..|     :...|.:: .|.|.|.....   ::||..||
  Rat   338 TGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSD-GGAYQCFVRKD---KLSAQDYV 398

  Fly   425 YL---KGSPAIGSQRTQYGL-VGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAV 485
            .:   .|:|.|.|..::..: ..:...:.|.....|... |:||.:...|...|||..|.::.: 
  Rat   399 QVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPT-VTWTLDDDPILKGSGHRISQMITS- 461

  Fly   486 PGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLL----MTIVGGISVVAFLL 546
            .|.|.|.|.|..||....|.|.||..|..|..:.:.::..:...|:.    :|.:.|..      
  Rat   462 EGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRD------ 520

  Fly   547 VLTILVVVYIKCK------------KRTKLPPADVISEHQIT-KNGGVSCKLEPGDRTSNYSDLK 598
                   .||.|:            |...|.|   .:..|:. :|.|          |...||::
  Rat   521 -------TYIHCRVIGYPYYSIKWYKNANLLP---FNHRQVAFENNG----------TLKLSDVQ 565

  Fly   599 VDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQ--QQSHHQHHTQT 661
            .:     |..|:|:.:....||    .||..:...|:.........:..:..  |:........:
  Rat   566 KE-----VDEGEYTCNVLVQPQ----LSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 621

  Fly   662 TTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNG--SCSNQSTTAATTTT 724
            ..||:|......|..:..|:    .:..|| :....|...|.:|...||  :|..::..||....
  Rat   622 GDLPITITWQKDGRPIPASL----GVTIDN-IDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681

  Fly   725 THVVVPSSMALSVDPR-YSAIYGNPYLRSSNSSLLPPPTAV 764
            :.::|.......|.|| ...|||...:.:.::...|.||.|
  Rat   682 SQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rstNP_001284835.1 IG_like 34..130 CDD:214653 26/117 (22%)
Ig 42..114 CDD:299845 18/92 (20%)
C2-set_2 135..225 CDD:285423 18/97 (19%)
Ig_3 265..329 CDD:290638 19/68 (28%)
I-set 346..420 CDD:254352 21/83 (25%)
Ig 360..425 CDD:299845 22/74 (30%)
Ig5_KIRREL3-like 428..524 CDD:143235 27/96 (28%)
IG_like 435..524 CDD:214653 23/89 (26%)
DscamXP_038943864.1 Ig 26..121 CDD:416386 24/109 (22%)
Ig strand A' 33..37 CDD:409353 0/3 (0%)
Ig strand B 40..49 CDD:409353 2/8 (25%)
Ig strand C 55..61 CDD:409353 3/10 (30%)
Ig strand C' 63..66 CDD:409353 0/2 (0%)
Ig strand D 72..75 CDD:409353 0/2 (0%)
Ig strand E 80..85 CDD:409353 2/4 (50%)
Ig strand F 98..106 CDD:409353 2/8 (25%)
Ig strand G 109..121 CDD:409353 4/13 (31%)
Ig 125..210 CDD:416386 20/104 (19%)
Ig strand A 126..130 CDD:409353 0/3 (0%)
Ig strand A' 132..136 CDD:409353 1/3 (33%)
Ig strand B 139..149 CDD:409353 2/17 (12%)
Ig strand C 157..163 CDD:409353 2/17 (12%)
Ig strand C' 164..167 CDD:409353 0/2 (0%)
Ig strand E 179..185 CDD:409353 1/5 (20%)
Ig strand F 191..201 CDD:409353 2/9 (22%)
IGc2 239..300 CDD:197706 20/62 (32%)
Ig strand B 242..246 CDD:409353 2/3 (67%)
Ig strand C 255..259 CDD:409353 2/3 (67%)
Ig strand F 290..295 CDD:409353 1/4 (25%)
Ig 313..395 CDD:416386 22/85 (26%)
Ig strand A 314..319 CDD:409353 0/4 (0%)
Ig strand A' 322..326 CDD:409353 0/3 (0%)
Ig strand B 329..339 CDD:409353 6/9 (67%)
Ig strand C 344..350 CDD:409353 2/5 (40%)
Ig strand C' 351..354 CDD:409353 0/2 (0%)
Ig strand E 368..374 CDD:409353 0/5 (0%)
Ig strand F 381..389 CDD:409353 3/7 (43%)
Ig 406..501 CDD:416386 26/96 (27%)
Ig strand A 406..409 CDD:409353 1/2 (50%)
Ig strand A' 415..419 CDD:409353 0/3 (0%)
Ig strand B 422..431 CDD:409353 1/8 (13%)
Ig strand C 436..442 CDD:409353 2/6 (33%)
Ig strand C' 444..447 CDD:409353 0/2 (0%)
Ig strand D 452..460 CDD:409353 3/7 (43%)
Ig strand E 464..473 CDD:409353 4/8 (50%)
Ig strand F 480..488 CDD:409353 4/7 (57%)
Ig strand G 491..501 CDD:409353 1/9 (11%)
Ig 504..593 CDD:416386 22/123 (18%)
Ig strand A 505..507 CDD:409353 0/1 (0%)
Ig strand A' 512..516 CDD:409353 1/3 (33%)
Ig strand B 519..526 CDD:409353 2/19 (11%)
Ig strand C 533..539 CDD:409353 0/5 (0%)
Ig strand C' 540..542 CDD:409353 0/1 (0%)
Ig strand D 549..553 CDD:409353 1/3 (33%)
Ig strand E 557..563 CDD:409353 2/15 (13%)
Ig strand F 571..579 CDD:409353 2/7 (29%)
Ig strand G 583..593 CDD:409353 2/9 (22%)
Ig 596..686 CDD:416386 16/94 (17%)
Ig strand A 597..599 CDD:409353 0/1 (0%)
Ig strand B 611..620 CDD:409353 1/8 (13%)
Ig strand C 625..632 CDD:409353 2/6 (33%)
Ig strand C' 634..636 CDD:409353 1/1 (100%)
Ig strand D 643..648 CDD:409353 2/5 (40%)
Ig strand E 651..658 CDD:409353 1/6 (17%)
Ig strand F 665..673 CDD:409353 2/7 (29%)
Ig strand G 676..685 CDD:409353 2/8 (25%)
Ig_DSCAM 689..784 CDD:409397 10/34 (29%)
Ig strand B 707..711 CDD:409397 0/3 (0%)
Ig strand C 720..724 CDD:409397 2/3 (67%)
Ig strand E 749..753 CDD:409397
Ig strand F 763..768 CDD:409397
Ig strand G 777..780 CDD:409397
Ig_DSCAM 785..884 CDD:409398
Ig strand B 805..809 CDD:409398
Ig strand C 818..822 CDD:409398
Ig strand E 848..852 CDD:409398
Ig strand F 862..867 CDD:409398
Ig strand G 875..878 CDD:409398
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig_3 1287..1363 CDD:404760
Ig strand B 1303..1307 CDD:409353
Ig strand C 1316..1320 CDD:409353
Ig strand E 1342..1346 CDD:409353
Ig strand F 1356..1361 CDD:409353
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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