DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and kirrel3

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_031761736.1	Gene:	kirrel3 / 105947809	XenbaseID:	XB-GENE-922296	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	819	Identity:	225/819 - (27%)
Similarity:	350/819 - (42%)	Gaps:	156/819 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLATIVGMVRSSPYT------------SYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQW 60
            |||.|.:.:.|.|..|            |.....|..:||||..|.|..|:|.|.:....|.|.|
Frog    12 LLLLTCILLSRESGLTLGFMSKDKFRKMSEGQSSFTQQPQDQVVVAGQPVSLLCAIPGYHGLLLW 76

  Fly    61 TKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAG 125
            .||...:|..|||||:.||::.|....|::.|.|....|.|||.|:||..     |.||||..|.
Frog    77 IKDGLAIGVGRDLSGYPRYSVGGDHLSGEHHLMIQRAELQDDAMYECQAI-----QAAIRSRPAR 136

  Fly   126 LTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQ 190
            |||||||:.|.||.|.||.......:.:.|.:...||||.|||:.. |.||.....|..: |.|.
Frog   137 LTVLVPPDDPVITGGPVISIRAGDPLNLTCHADNAKPAATITWMKN-GEVLNGATYYKTL-LRDG 199

  Fly   191 RRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSV 255
            :|.:..|.|.::.....:....:|:|.|.|....:.|.:.:.:::.|.|.:.|
Frog   200 KRESIISTLFVSSSDIENGQTITCRATNKAVPGGKEATVTINIQHPPLVNLTV------------ 252

  Fly   256 GGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHD 320
                       ....::|.:.|:..|.|.|||:..:|||      ..|||    :::.||.:.::
Frog   253 -----------EPQPVLEDNVVKFHCAAKANPAVTQYRW------AKGGQ----ILKEVTDETYE 296

  Fly   321 AI---------VKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPE 376
            .:         |.|||.|::|.:..|.|:|:.:.|.....|:|:..|:||..:..|....||...
Frog   297 TVVDFSFFTEPVSCEVTNALGSTNVSRTVDVYFGPRMSSEPESITVDLGSDATFHCAWIGNPSLT 361

  Fly   377 IVWIQHPSDRVVGTSTNLTF-SVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYG 440
            |||::..|..|:.....||. :|..|.||:|.|:|.||.......|..:.:.|.|.|.|.:||:.
Frog   362 IVWMKRGSGVVLSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERDISLTVNGPPIISSTQTQHA 426

  Fly   441 LVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTL----IIR-DSQA 500
            |.|:..:|:||..|.|....::|::....:.|.:...|::...:...||.|||    |:| |.|.
Frog   427 LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVSTDEGVISTLTISNIVRADFQT 491

  Fly   501 YHYGKYNCTVVNDYGNDVAEIQLQ----------AKKSVSLLMTIVGGISV---VAFLLVLTILV 552
            .    ||||..|.:|:|...|:|:          :.:..|:.:|::.|::|   ||||:::..:|
Frog   492 I----YNCTAWNSFGSDTEIIRLKEQGPNMQSGTSMEPESVPVTVIIGVAVGAGVAFLVLMATIV 552

  Fly   553 VVYIKCKKRTKLPPADVISEHQITKNGGVSCK---------LEP--GDRTSNYSDLK-VDISGGY 605
                          |...:.:|....|.||.|         .||  |..|.::|.:| :.|..|.
Frog   553 --------------AFCCARNQRNLKGVVSAKNDIRVEIVHKEPSTGRETEDHSTIKQLMIDRGE 603

  Fly   606 VPYG--------------DYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQ----- 651
            ....              ::.....|...|.:..:.|.:.:.||..:|.|..|:...:|:
Frog   604 FQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKDHSTPTISLSNCQQDLRPANKQRVPTGM 668

  Fly   652 -----------QSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPS---LQSTTAS 702
                       |:....::|...|.|    .||...|.     .||.::.:...|   |.:...|
Frog   669 SFTNIYSTLSGQNRLYDYSQRFVLGM----GSSSIELC-----EREFQRGSMSDSSSFLDTQCDS 724

  Fly   703 VVSSS--PNGSCSNQSTTAATTTTTHVVVPSSMALSVDP 739
            .||||  .:|......::.|:.:::|....||.  :.||
Frog   725 SVSSSGKQDGYVQFDKSSKASASSSHYSQSSSQ--NSDP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	42/95 (44%)
		Ig	42..114	CDD:299845	28/71 (39%)
		C2-set_2	135..225	CDD:285423	27/89 (30%)
		Ig_3	265..329	CDD:290638	19/72 (26%)
		I-set	346..420	CDD:254352	25/74 (34%)
		Ig	360..425	CDD:299845	22/65 (34%)
		Ig5_KIRREL3-like	428..524	CDD:143235	33/100 (33%)
		IG_like	435..524	CDD:214653	29/93 (31%)
kirrel3	XP_031761736.1	IG	50..139	CDD:214652	40/93 (43%)
		IgI_2_KIRREL3-like	145..242	CDD:409416	28/98 (29%)
		Ig strand B	162..166	CDD:409416	0/3 (0%)
		Ig strand C	176..180	CDD:409416	2/3 (67%)
		Ig strand E	206..210	CDD:409416	2/3 (67%)
		Ig strand F	220..225	CDD:409416	1/4 (25%)
		Ig strand G	235..238	CDD:409416	1/2 (50%)
		Ig	331..412	CDD:416386	26/80 (33%)
		Ig strand A'	339..343	CDD:409353	1/3 (33%)
		Ig strand B	346..356	CDD:409353	2/9 (22%)
		Ig strand C	361..367	CDD:409353	3/5 (60%)
		Ig strand E	377..383	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	414..511	CDD:409479	33/100 (33%)
		Ig strand B	432..436	CDD:409479	1/3 (33%)
		Ig strand C	446..450	CDD:409479	0/3 (0%)
		Ig strand E	477..481	CDD:409479	3/3 (100%)
		Ig strand F	492..497	CDD:409479	3/8 (38%)
		Ig strand G	505..508	CDD:409479	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3020
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm9365
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060