DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rst and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	666	Identity:	183/666 - (27%)
Similarity:	283/666 - (42%)	Gaps:	93/666 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHTMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDF 65
            :||.....|.:.|..::.|||:       |..:|:|...::|....|||.:...:|.:|||||..
  Rat    12 VLHKGIPFLSSAIPLLLGSSPH-------FLQQPEDMVVLLGQEARLPCALGAYRGLVQWTKDGL 69

  Fly    66 GLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLV 130
            .||..|||.|:.||.:.|:...|.:.|.|.||.|:|:|.|:||.|     |..:||..|.|.|:|
  Rat    70 ALGGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQAS-----QAGLRSRPAQLHVMV 129

  Fly   131 PPEAPKITQGDVIYATEDRKVEIECVSVG-GKPAAEITWI-DGLGNVLTDNIEYTVIPLPDQRRF 193
            |||||::..|..:.........:.|.|.| .:||.|:.|. ||   :..|...:..|.|.|:...
  Rat   130 PPEAPQVLGGPSVSLVAGVPGNLTCRSRGDARPAPELLWFRDG---IRLDGTSFHQITLRDKATG 191

  Fly   194 TAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGA 258
            |.::.|.|||..:.......|:|::.|..|.|...:.:.::|.|.|.:
  Rat   192 TVENTLFLTPSSQDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTL----------------- 239

  Fly   259 GGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIG--GQKTEMVIRNVTRKFHDA 321
               |....|..   |..:|...|:|.|.|....|||.....|::|  |.:.| |:.:.|  |...
  Rat   240 ---SAEPQTAQ---EGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE-VVADAT--FLTE 295

  Fly   322 IVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDR 386
            .|.|||.|:||.:..|..|::.|.|..:.:|:.:..|||...|.:|....||.|.|.|.:....:
  Rat   296 PVSCEVSNAVGSANRSTALEVLYGPILQAKPKPVSVDVGKDASFSCVWRGNPLPRISWTRLGGSQ 360

  Fly   387 VVGTSTNLTF-SVSNETAGRYYCKANV--PGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARI 448
            |:.:...|.. ||:.|.||.|.|:|..  .|....:|.|.:.:...|.:.:.......:...||:
  Rat   361 VLSSGPTLRLPSVALEDAGDYVCRAEPRRTGVGGGTAQARLTVNAPPVVTALHPAPAFLRGPARL 425

  Fly   449 ECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPG---------GVKSTLIIRDSQAYHYG 504
            :|...:.|....|.|:::  |...|:|.....||:|.|.         |:.|.|.|..:|...:.
  Rat   426 QCVVFASPAPDSVVWSWD--EGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFT 488

  Fly   505 K-YNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVV-------YIKCKKR 561
            . :||:..|..|....:|.|..:..:..:..:.|..|....|.::...||:       ..|.|..
  Rat   489 TGFNCSARNRLGEGRVQIHLGRRDLLPTVRLVAGAASAATSLFMVITGVVLCCWRHGSLSKQKNL 553

  Fly   562 TKLP-PADVISEHQITKNGGVS-------------------CKLEPGDRTSNYSDLK---VDISG 603
            .::| .::..|.|...:..|.|                   ..||..|.|:.|..::   |.:|.
  Rat   554 VRIPGSSEGSSAHGPEEETGSSEDRGPIVHTDHNDLVLEENEALETKDPTNGYYKVRGVSVSLSL 618

  Fly   604 GYVPYGDYSTHYSPPP 619
            |..|.|..   :.|||
  Rat   619 GEAPGGGL---FLPPP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	39/95 (41%)
		Ig	42..114	CDD:299845	31/71 (44%)
		C2-set_2	135..225	CDD:285423	24/91 (26%)
		Ig_3	265..329	CDD:290638	21/65 (32%)
		I-set	346..420	CDD:254352	23/76 (30%)
		Ig	360..425	CDD:299845	21/67 (31%)
		Ig5_KIRREL3-like	428..524	CDD:143235	24/105 (23%)
		IG_like	435..524	CDD:214653	23/98 (23%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	38/93 (41%)
		Ig strand A'	40..44	CDD:409353	1/3 (33%)
		Ig strand B	48..57	CDD:409353	3/8 (38%)
		Ig strand C	62..66	CDD:409353	2/3 (67%)
		Ig strand D	75..85	CDD:409353	6/9 (67%)
		Ig strand E	88..100	CDD:409353	3/11 (27%)
		Ig strand F	107..115	CDD:409353	5/12 (42%)
		Ig strand G	117..127	CDD:409353	4/9 (44%)
		Ig	133..231	CDD:416386	26/100 (26%)
		Ig strand A	134..137	CDD:409353	1/2 (50%)
		Ig strand A'	140..144	CDD:409353	0/3 (0%)
		Ig strand B	151..158	CDD:409353	2/6 (33%)
		Ig strand C	164..169	CDD:409353	1/4 (25%)
		Ig strand C'	172..174	CDD:409353	1/4 (25%)
		Ig strand D	177..184	CDD:409353	0/6 (0%)
		Ig strand E	191..199	CDD:409353	2/7 (29%)
		Ig strand F	208..216	CDD:409353	2/7 (29%)
		Ig strand G	222..228	CDD:409353	1/5 (20%)
		Ig_3	234..303	CDD:404760	24/94 (26%)
		Ig strand B	252..256	CDD:409353	1/3 (33%)
		Ig strand C	266..270	CDD:409353	2/3 (67%)
		Ig strand E	283..286	CDD:409353	1/3 (33%)
		Ig strand F	292..301	CDD:409353	3/8 (38%)
		Ig strand G	309..312	CDD:409353	0/2 (0%)
		Ig	326..403	CDD:416386	24/76 (32%)
		Ig strand A'	327..332	CDD:409353	0/4 (0%)
		Ig strand B	335..344	CDD:409353	2/8 (25%)
		Ig strand C	350..354	CDD:409353	1/3 (33%)
		Ig strand C'	357..359	CDD:409353	0/1 (0%)
		Ig strand D	362..365	CDD:409353	0/2 (0%)
		Ig strand E	366..371	CDD:409353	1/4 (25%)
		Ig strand F	379..387	CDD:409353	4/7 (57%)
		Ig strand G	393..403	CDD:409353	2/9 (22%)
		Ig	405..509	CDD:416386	24/105 (23%)
		Ig strand A	406..410	CDD:409353	1/3 (33%)
		Ig strand A'	412..415	CDD:409353	0/2 (0%)
		Ig strand B	423..430	CDD:409353	3/6 (50%)
		Ig strand C	437..442	CDD:409353	2/4 (50%)
		Ig strand C'	444..447	CDD:409353	1/2 (50%)
		Ig strand D	455..462	CDD:409353	3/6 (50%)
		Ig strand E	472..479	CDD:409353	3/6 (50%)
		Ig strand F	490..497	CDD:409353	2/6 (33%)
		Ig strand G	500..507	CDD:409353	1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342412
Domainoid	1	1.000	87	1.000	Domainoid score	I7807
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.760