DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and kirrel2

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001135598.1	Gene:	kirrel2 / 100216155	XenbaseID:	XB-GENE-854070	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	230/807 - (28%)
Similarity:	342/807 - (42%)	Gaps:	125/807 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSRD 72
            |||...||::....:.::    |:.:|.|:..|.|..|||||.||..:|.:|||.|...||..||
Frog     6 LLLWIHVGLLLGKSFGAH----FSQQPSDKVIVAGKSVTLPCVVIGYRGVVQWTMDGLALGAERD 66

  Fly    73 LSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKI 137
            |.|:.||::||....|:::|.|..|.|.|||.|:||.:     |.|:||..|.||||:||..|.|
Frog    67 LPGWSRYSVVGDPSLGEHNLHIEGVELSDDAIYECQAT-----QAALRSQRARLTVLLPPGDPMI 126

  Fly   138 TQGDVIYATEDRKVEIECVSVGGKPAAEITWI-DGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRL 201
            ....|.....:....:.|::...||||||||. ||   ...|:..||...|.|.:...:.|.|.:
Frog   127 PGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDG---KKLDSAVYTKELLSDGKSEGSASSLLI 188

  Fly   202 TPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMS 266
            ||......::::|:.:|.|....|...:.:.|:|.|||.:                    ||...
Frog   189 TPSLADSGSSYTCRVRNEALPEGREKSVTLSVQYPPKVTL--------------------SVEPP 233

  Fly   267 TGSRIVEHSQVRLECRADANPSDVRYRWFINDEPI-IGGQKTEMVIRNVTRKFHDAIVKCEVQNS 330
            |   |.|...|...|.|.:||....|||.....|: :.|.|..:   .|...|..|.|.|||.||
Frog   234 T---ITEGGSVTFLCGAVSNPEVTGYRWAKGGVPLAVSGDKYTV---EVDHTFFTAPVSCEVSNS 292

  Fly   331 VGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGT-STNL 394
            ||.|..|..:::.:.|.....|:.|..|:|...|..|....||.|...|.:..:..|:.. :|.|
Frog   293 VGASNVSTAVNVLFGPRLLTEPRPMTVDIGDDASFFCGWTGNPTPTQFWSKKGTGEVLSNGNTLL 357

  Fly   395 TFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRAR 459
            ...|:.|.||.|.|||.||.......:..:.::|.|.|.|:......:|..||:||...|.|...
Frog   358 LTKVTREDAGIYVCKAIVPRMGSTEKEVTLTVRGPPIITSEMHYETTLGGKARMECLIESTPAPD 422

  Fly   460 HVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDS-QAYHYGKYNCTVVNDYGND--VAEI 521
            .:.|.::.|.:...|...:|:..:....|..|.|:|..: |:....::||:.:|.||.|  :..:
Frog   423 RIVWAWDKQSLEDGSWGRFSVETEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSL 487

  Fly   522 QLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQITK---NGGVSC 583
            :.||...::||:..||..::..|:||:|.::     |.:|    |...:.:.||..   :|....
Frog   488 RQQAALPLTLLLIAVGSGTLCIFVLVITSIL-----CCRR----PKKAVKDTQILAVDVSGSEPS 543

  Fly   584 KLEPGD----------------RTS--NYSDL---KVDISGGY-------------VPYGDYSTH 614
            :..|.|                |||  .:||:   ..|.:.||             :.|.::|
Frog   544 ERHPSDSEEDLKEPLHTDTESQRTSQTEHSDIPDEPQDPTNGYYKVRAHEDTRPTTITYPEFS-- 606

  Fly   615 YSPP-PQYLTT------CSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLTNS 672
             ||| |.|.||      |.|.| |...|....|:   .....:...||.....::.||.
Frog   607 -SPPRPLYSTTSSLSPLCPTPS-GPPKIYDYAHR---YATTPRSGGHHMPQGSSSHLPQ------ 660

  Fly   673 SGGSLTGSIIGSREIRQ-DNGLPSLQSTTASVVSSSPNGSCS-NQSTTAATTTTTHVV-VPSSM- 733
                      |:..:.| ...||.:.:......:..|.|... .|..|......||:. .||.:
Frog   661 ----------GTTHLPQGPMHLPQVPTHLPQAPTYLPQGPTHLPQGPTHLPQGPTHLPHGPSHLQ 715

  Fly   734 -ALSVDPRYSAIYGNPYLRSSNSSLLP 759
             .||..|...:.:..||.|:..|.:.|
Frog   716 QGLSHLPPGPSQHSAPYARAFCSYVRP 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	45/95 (47%)
		Ig	42..114	CDD:299845	34/71 (48%)
		C2-set_2	135..225	CDD:285423	26/90 (29%)
		Ig_3	265..329	CDD:290638	21/64 (33%)
		I-set	346..420	CDD:254352	24/74 (32%)
		Ig	360..425	CDD:299845	20/65 (31%)
		Ig5_KIRREL3-like	428..524	CDD:143235	26/98 (27%)
		IG_like	435..524	CDD:214653	22/91 (24%)
kirrel2	NP_001135598.1	IG_like	28..117	CDD:214653	43/93 (46%)
		Ig2_KIRREL3-like	139..220	CDD:143236	24/83 (29%)
		Ig_2	225..294	CDD:372793	27/94 (29%)
		Ig	308..389	CDD:386229	24/80 (30%)
		Ig	391..488	CDD:386229	26/96 (27%)
		Atrophin-1	529..>765	CDD:367360	52/237 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3020
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm9365
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060