DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rst and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	771	Identity:	197/771 - (25%)
Similarity:	311/771 - (40%)	Gaps:	128/771 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSRDLSGFE 77
            ||.:...|.:..:...||:.||.||:.|:|.||.|.|.|.|..|.:|||||...||...||..:.
Zfish    10 IVTLAIISVHRVFSGPRFSQEPADQSVVIGERVVLSCVVFNYTGIVQWTKDGLALGIGEDLRAWP 74

  Fly    78 RYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDV 142
            ||.::...:.|.|:|:|....|.||:.|:||.:     :.|:||..|.||||:||:.|.|.....
Zfish    75 RYRVLRIMDVGQYNLEITSADLTDDSLYECQAT-----EAALRSRRAKLTVLIPPDGPVIEGSPE 134

  Fly   143 IYATEDRKVEIECVSVGGKPAAEITWI-DGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKE 206
            |..|......:.|||.|.||.:.|.|. ||   ::.:....:...|.|::|.|.||.|.:.|...
Zfish   135 ILLTAGTSFNLTCVSRGAKPMSTIEWYKDG---IIVEGAHTSTEVLSDRKRVTTKSFLEIQPMDT 196

  Fly   207 HHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRI 271
            ....||:|.|.|.|....:.:.:.:.:.:.|.|.:::                       ....:
Zfish   197 DTGRNFTCVASNLAAPLGKRSTVTLNIHHPPTVILSI-----------------------EPRSV 238

  Fly   272 VEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSED 336
            :|..:|:..|:|.|||..:.||| .....|:.|.:..:........|....|.|.|.|:||.:..
Zfish   239 LEGERVKFTCQATANPPIMGYRW-AKGGVILDGARESVFETTADHSFFTEPVSCLVFNAVGSTNV 302

  Fly   337 SETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTSTNLTF-SVSN 400
            |..:|:.:.|.....|:.:..||.|.|:|.|:...||...:.|.:..|..|:..|..|.. |||.
Zfish   303 SILVDVHFGPILVVEPRPVTVDVDSDVTLNCKWSGNPPLTLTWTKKGSSMVLSNSNQLFLKSVSQ 367

  Fly   401 ETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTF 465
            ..||:|.|||.||.......:..:.:.|.|.|.|:..||.:.|:...|:|:.:|.|....:.|.:
Zfish   368 ADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPIQYAVRGEKGEIKCYIASTPPPDKIVWAW 432

  Fly   466 NGQEISSESG---HDYSILVD--AVPGG-VKSTLIIRD-SQAYHYGKYNCTVVNDYGNDVAEIQL 523
            .......|.|   ..|::...  |..|| |.|||.|.: .:|.....||||..|.:|.....|.|
Zfish   433 KENVWEKERGTLLERYTVEQSRPATQGGAVLSTLTINNVMEADFQSTYNCTAWNAFGPGTMIITL 497

  Fly   524 Q----AKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQITKNGGVSCK 584
            :    |.:.:..:..|.||....:.||:|.:..:::...::|.             :...||:.|
Zfish   498 EETDIASEDIVPVGVIAGGSVGSSILLLLLLFALIFYLYRQRK-------------SSRRGVTLK 549

  Fly   585 LEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQ 649
                      .|:||:                       |.:.::|                 .:
Zfish   550 ----------PDIKVE-----------------------TVNKETN-----------------LE 564

  Fly   650 QQQSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNGSCSN 714
            ::.:.....|:......:||.:.|....|.......:::||....:|:.......:..|.....|
Zfish   565 EEAASASTATRMVKAMYSFLPSVSLSPSTQPFKDDMDLKQDLQTETLEPKVEEYEAKDPTNGYYN 629

  Fly   715 QSTTAATTTTTHVVVPSSMALSVDPRY--------SAIYGNPYLRSSNSSLLPPPT 762
                  ...|||..|.||....:...:        ||..|.|      :::.|.||
Zfish   630 ------VRATTHDEVRSSTRSLLYQEFRAPNPASVSASTGGP------ANIHPAPT 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rst	NP_001284835.1	IG_like	34..130	CDD:214653	40/95 (42%)
		Ig	42..114	CDD:299845	29/71 (41%)
		C2-set_2	135..225	CDD:285423	28/90 (31%)
		Ig_3	265..329	CDD:290638	16/63 (25%)
		I-set	346..420	CDD:254352	26/74 (35%)
		Ig	360..425	CDD:299845	22/65 (34%)
		Ig5_KIRREL3-like	428..524	CDD:143235	31/102 (30%)
		IG_like	435..524	CDD:214653	27/95 (28%)
kirrel1b	XP_017212964.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582418
Domainoid	1	1.000	84	1.000	Domainoid score	I8167
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10089
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm6357
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.660