DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3603 and HSD17B8

DIOPT Version :9

Sequence 1:	NP_001259199.1	Gene:	CG3603 / 31289	FlyBaseID:	FBgn0029648	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_055049.1	Gene:	HSD17B8 / 7923	HGNCID:	3554	Length:	261	Species:	Homo sapiens

Alignment Length:	252	Identity:	127/252 - (50%)
Similarity:	169/252 - (67%)	Gaps:	10/252 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LAGKVALVTGAGSGIGRATCRLLARDGAKVIAVDRNLKAAQETVQELGSERS---------AALE 61
            |...:|||||||||||||....||.:||.|.|.|.:..||||||:.||...|         ||.:
Human     9 LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQ 73

  Fly    62 VDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLVTQAY 126
            .|||.|::.:..:.:....|.:.|::||:.||||:|.:||.|.|.|:|.|..||||||||||||.
Human    74 ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAA 138

  Fly   127 AKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTEVASKEFGKFGIRVNCILPGYI 191
            |:|::.... .|:|:|:||||.|:.||||.||||:|||||..|:.|::|.|:.|||.|.:|||:|
Human   139 AQALVSNGC-RGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFI 202

  Fly   192 DTPMVAVVPDSVKQEVVQRCPLGRLGQPEEIAEVIAFLASPQSSYVNGAAIEVTGGL 248
            .|||...||..|..::.:..|:|.||.||::|:|:|||||..|.|:.|.::||||||
Human   203 ATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGL 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3603	NP_001259199.1	fabG	6..248	CDD:235546	125/250 (50%)
CG3603	NP_001259199.1	BKR_SDR_c	9..248	CDD:187594	124/247 (50%)
HSD17B8	NP_055049.1	BKR_SDR_c	13..260	CDD:187594	126/248 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156701
Domainoid	1	1.000	228	1.000	Domainoid score	I2497
eggNOG	1	0.900	-	-		E2759_KOG1200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56588
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3396
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S1824
OMA	1	1.010	-	-		QHG49380
OrthoDB	1	1.010	-	-		D1226147at2759
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	1	1.000	-	-		oto89224
orthoMCL	1	0.900	-	-		OOG6_100272
Panther	1	1.100	-	-	LDO	PTHR42760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1710
SonicParanoid	1	1.000	-	-		X181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750