DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3526 and Rnf125

DIOPT Version :9

Sequence 1:	NP_726832.2	Gene:	CG3526 / 31277	FlyBaseID:	FBgn0040355	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001351902.1	Gene:	Rnf125 / 67664	MGIID:	1914914	Length:	233	Species:	Mus musculus

Alignment Length:	224	Identity:	51/224 - (22%)
Similarity:	69/224 - (30%)	Gaps:	82/224 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RTHELSGSPSM----------------PRRRQIGHTSGHCNVRCDGC------GNNRMTFYRYKC 47
            ||.|.||...:                |.|.:.||      |.|..|      .||:.|     |
Mouse    20 RTLERSGDSELPITSFDCSVCLEVLHQPVRTRCGH------VFCRSCIATSIKNNNKWT-----C 73

  Fly    48 LHC-------------------LDYDLCSDCKENGVSNGLHSLDHPLQCLMDRDALELH------ 87
            .:|                   .:|..|::|             ..|.||.|   :..|
Mouse    74 PYCRAYLPSEGVPATDIAKRMKSEYQNCAEC-------------GTLVCLSD---MRAHIRTCEK 122

  Fly    88 FAGEPIPILCADSFT----CPVCGEMGFSVEDLRTHCQDNHRMARTVCICPVCAAVPLSQPSHI- 147
            :..:..|:|.....|    ||.| :.....:.|..||..:||..|....||:|.:.|...||..
Mouse   123 YIDKYGPLLELGDTTARCVCPFC-QRELDEDCLLDHCIIHHRSERRPVFCPLCHSRPDESPSTFN 186

  Fly   148 AHIANHLMFSPSHRATGDPMIDISATSQA 176
            ..:..||..  ||....|..||.....:|
Mouse   187 GSLIRHLQV--SHTLFYDDFIDFDIIEEA 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3526	NP_726832.2	ZZ_PCMF_like	30..78	CDD:239078	12/72 (17%)
CG3526	NP_726832.2	zf-Di19	99..149	CDD:283297	16/54 (30%)
Rnf125	NP_001351902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		4/6 (67%)
		RING_Ubox	35..77	CDD:327409	11/52 (21%)
		Interaction with the C2HC RNF-type zinc finger. /evidence=ECO:0000250\|UniProtKB:Q96EQ8	43..45		0/1 (0%)
		Interaction with the RING-type zinc finger. /evidence=ECO:0000250\|UniProtKB:Q96EQ8	110..114		2/6 (33%)
		Linker region. /evidence=ECO:0000250\|UniProtKB:Q96EQ8	121..129		0/7 (0%)
		zf-Di19	142..>174	CDD:310299	11/32 (34%)
		Required for interaction with ubiquitin and for autoubiquitination	211..225		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870