Protein Alignment w and ABCG2

DIOPT Version :9

• Sequence 1: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_001335914.1
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 210/655 - (32%)
• Similarity: 344/655 - (52%)
• Gaps: 60/655 - (9%)

  Fly    74 NMDIFGAVNQ------PGSGWRQLVNRTRGLFCNERHI-----------PAPR---KHLLKNVCG 118
            |:::|..|:|      |.:....|...|.|...:..:|           |..:   |.:|.|:.|
Human     5 NVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNING 69

  Fly   119 VAYPGELLAVMGSSGAGKTTLLNALAFR-SPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDD 182
            :..|| |.|::|.:|.||::||:.||.| .|.|:    ||..|:||.|..| ..:....||.|||
Human    70 IMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGL----SGDVLINGAPRPA-NFKCNSGYVVQDD 128

  Fly   183 LFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERK 247
            :.:|:||.||:|.|.|.:|:...:|..::..|:::|||||.|.|...:.:|.. .::|:||||||
Human   129 VVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQ-FIRGVSGGERK 192

  Fly   248 RLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKIL 312
            |.:...|.:|||.:|..||||:||||.||::|:.:||::|::|:|:|.:||||...:|:|||.:.
Human   193 RTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLT 257

  Fly   313 LMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVL-----AVVPGREIESR-------- 364
            |:|.||:.|.|...||:.:|...|..|....|||||::.::     ||...||.:.:
Human   258 LLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPS 322

  Fly   365 -------DRIAKICDNFAISKVAR-DMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSW 421
                   :::|:|..|.:..|..: ::.||...:..:|.....|..||  .::..|.|.|..||:
Human   323 KQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYT--TSFCHQLRWVSKRSF 385

  Fly   422 LSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFT 486
            .::|..|.....::|.|.::.::||.|:.|.:....|:.|..|.:|...||..|.:|.| :.:|.
Human   386 KNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSA-VELFV 449

  Fly   487 SELPVFMREARSRLYRCDTYFLGKTIAE-LPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVT 550
            .|..:|:.|..|..||..:|||||.::: ||:.:...::||.|.|.|:||:.....||..:..:.
Human   450 VEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLM 514

  Fly   551 LVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANE 615
            :||..::|....|:...|..|:|..:.....:..::|.|..:|..::..:|.||.|.|..||...
Human   515 MVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFT 579

  Fly   616 GLLINQWADVE--PGEISCTSSN----TTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVL 674
            .|..|::....  || ::.|.:|    .||.....::.:.::.|...|..::|.||.:||.|..:
Human   580 ALQHNEFLGQNFCPG-LNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTI 643

  Fly   675 AYLAL 679
            |||.|
Human   644 AYLKL 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	210/655 (32%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	200/605 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6648
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55852
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2636
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.700