DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and PDR10

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_014973.1	Gene:	PDR10 / 854506	SGDID:	S000005855	Length:	1564	Species:	Saccharomyces cerevisiae

Alignment Length:	757	Identity:	198/757 - (26%)
Similarity:	322/757 - (42%)	Gaps:	151/757 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLT 69
            |.:..|.|..|..:.||.:: .|.:||||                      :|.|.|..:..:.:
Yeast   878 DSDAAIMGNDKTVAKEHYSS-PSSSASQS----------------------NSFSKSDDIELSKS 919

  Fly    70 YAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGA 134
            .|     ||        .|:.|        |.:..|...::.:|.||.|...||.|.|::|:|||
Yeast   920 QA-----IF--------HWKNL--------CYDIPIKNGKRRILDNVDGWVKPGTLTALIGASGA 963

  Fly   135 GKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAM 199
            ||||||:.||.|:..|:   .:|...::|:|.| :.......|.||.||.:.:.|.||.|.|.|.
Yeast   964 GKTTLLDCLAERTTMGL---ITGDVFVDGRPRD-QSFPRSIGYCQQQDLHLKTATVRESLRFSAY 1024

  Fly   200 VRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLI- 263
            :|....::..::...|::||:.|.:......|:||||  :||:..:||||....|....|.||:
Yeast  1025 LRQADDVSIEEKDKYVEEVIEVLEMKLYADAIVGVPG--EGLNVEQRKRLTIGVELAAKPKLLVF 1087

  Fly   264 CDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPSE 327
            .|||||||||.||.|..|::|||:.:|:.::.||||||:.|.:.||::|.:.| |:..:.|...:
Yeast  1088 LDEPTSGLDSQTAWSTCQLMKKLASRGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGELGK 1152

  Fly   328 A----VDFFSYVGA-QCPTNYNPADFYVQVLAVVPGREIESRDRIAKICDNFAI---SKVARDME 384
            .    :::|...|| :||.:.|||::.::::...||.....        |.|||   |:..|:|:
Yeast  1153 GCKTMINYFEAHGAHKCPPDANPAEWMLEIVGAAPGTHASQ--------DYFAIWRDSEEYREMQ 1209

  Fly   385 QLLATKNLEKPL--------EQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMV 441
            :.|.....|.|.        ||.|    :..:...|.:.|.:|.:....:.|..:..:...|.:.
Yeast  1210 KELDWMERELPKRTEGSSNEEQKE----FATSTLYQIKLVSYRLFHQYWRTPFYLWSKFFSTIVS 1270

  Fly   442 AILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFM--------REARS 498
            .:.||..|.....:..|:.|...|||:|..      ||..|  ....||:|:        ||..|
Yeast  1271 ELFIGFTFFKANTSLQGLQNQMLAIFMFTV------VFNPI--LQQYLPLFVQQRELYEARERPS 1327

  Fly   499 RLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGL------------RAGVLHFFNCLALVTL 551
            |.:....:.:.:.:.|:|..|....:...:.|..:|.            |..:...|.|...|.:
Yeast  1328 RTFSWKAFIVSQILVEIPWNLLAGTIAFFVYYYPVGFYRNASYANQLHERGALFWLFACAFYVYI 1392

  Fly   552 VANVSTSFGYL-ISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANE 615
                 :|.|.| |||...:.: |.::.....|..|.|.|.......:|.:..::..:|...|..:
Yeast  1393 -----SSMGVLVISCIEIAEN-AANLASLFFIMSLSFCGVLATPNILPRFWIFMYRVSPLTYLID 1451

  Fly   616 GLLINQWAD-------------VEPGEISCT------------------SSNTTCP----SSGKV 645
            .||....|:             |.|..::|:                  ||.|.|.    ||...
Yeast  1452 ALLSVGLANASVVCSSNELLKIVPPSGMTCSEYMEPYMQSTGTGYLLDGSSETECHFCQFSSTND 1516

  Fly   646 ILETLNFSAADLPLDY-VGLAILIVSFRVLAYLALRLRARRK 686
            .|.|::.|.:...::| :..|.::..:....:|...:|..:|
Yeast  1517 YLATVSSSYSRRWMNYGIFSAYIVFDYCAAIFLYWLVRVPKK 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	184/694 (27%)
PDR10	NP_014973.1	3a01205	110..1556	CDD:273362	197/753 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	1	0.960	-	-
	4	3.890