DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and PDR5

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	737	Identity:	199/737 - (27%)
Similarity:	307/737 - (41%)	Gaps:	166/737 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KNYGTL--RPPSPPEDSGSGSG------QLAENLTYAWHNMDIFGAVNQPGS----GWRQLVNRT 95
            |..|.|  :..:.||:.|..|.      .|.|:   :....|.:|.:....|    .||.|
Yeast   817 KKRGVLTEKNANDPENVGERSDLSSDRKMLQES---SEEESDTYGEIGLSKSEAIFHWRNL---- 874

  Fly    96 RGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRL 160
                |.|..|.|..:.:|.||.|...||.|.|:||:|||||||||:.||.|...|:   .:|..|
Yeast   875 ----CYEVQIKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGV---ITGDIL 932

  Fly   161 LNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLS 225
            :||.|.| |.......|.||.||.:.:.|.||.|.|.|.:|.|..::..::...|::||:.|.:.
Yeast   933 VNGIPRD-KSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEME 996

  Fly   226 KCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLI-CDEPTSGLDSFTAHSVVQVLKKLSQK 289
            |....::||.|  :||:..:||||....|....|.||: .|||||||||.||.|:.|::|||:..
Yeast   997 KYADAVVGVAG--EGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANH 1059

  Fly   290 GKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPSEA----VDFFSYVGA-QCPTNYNPADF 348
            |:.::.||||||:.|.:.||::|.|.. |:..:.|...|.    :|:|...|| :||.:.|||::
Yeast  1060 GQAILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEW 1124

  Fly   349 YVQVLAVVPGREIESRDRIAKICDNFAISKVARDMEQLLATKN----LEKPLEQPENGYTYKATW 409
            .::|:...||...           |....:|.|:.|:..|.::    :|:  |.|:.|....|..
Yeast  1125 MLEVVGAAPGSHA-----------NQDYYEVWRNSEEYRAVQSELDWMER--ELPKKGSITAAED 1176

  Fly   410 FMQFRAVLWRSWLSVLKEPLLVKVRLIQ---------------TTMVAILIGLIFLGQQLTQVGV 459
            ..:|..       |::.:..||.:||.|               |....:.||..|.....:..|:
Yeast  1177 KHEFSQ-------SIIYQTKLVSIRLFQQYWRSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGL 1234

  Fly   460 MNINGAIFLFLTNMTFQNVFATINVFTSELPVFM--------REARSRLYRCDTYFLGKTIAELP 516
            .|...|:|:|..      :|..|  ....||.|:        ||..||.:...::...:...|:|
Yeast  1235 QNQMLAVFMFTV------IFNPI--LQQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVP 1291

  Fly   517 LFLTVPLVFTAIAYPMIGL-----RAGVLH-------FFNCLALVTLVANVS---TSFGYLISCA 566
            ..:....:...|.|..||.     .||.||       .|:| |....|.::.   .||..:...|
Yeast  1292 WNILAGTIAYFIYYYPIGFYSNASAAGQLHERGALFWLFSC-AFYVYVGSMGLLVISFNQVAESA 1355

  Fly   567 SSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVE----- 626
            ::..|:..::.       |.|.|......::|.:..::..:|...|..:.||....|:|:
Yeast  1356 ANLASLLFTMS-------LSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQALLAVGVANVDVKCAD 1413

  Fly   627 --------PGEISC----------------TSSNTTCPSSGKVILETLNFSAADLPLDYV----- 662
                    |..::|                |..|.|         :|.:|.......||:
Yeast  1414 YELLEFTPPSGMTCGQYMEPYLQLAKTGYLTDENAT---------DTCSFCQISTTNDYLANVNS 1469

  Fly   663 ---------GLAILIVSFRVLA 675
                     |:.|..::|..:|
Yeast  1470 FYSERWRNYGIFICYIAFNYIA 1491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	190/704 (27%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	199/737 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2636
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	1	0.960	-	-
	6	5.750