Protein Alignment w and PDR15

DIOPT Version :10

• Sequence 1: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_010694.1
• Gene: PDR15 / 852015
• SGDID: S000002814
• Length: 1529
• Species: Saccharomyces cerevisiae
• Alignment Length: 670
• Identity: 179/670 - (26%)
• Similarity: 293/670 - (43%)
• Gaps: 99/670 - (14%)

  Fly    40 GQAKNYGTLRPPSPP------EDSGSGSGQLAENLTYAWHNMD-IFGAVNQPGSGWRQLVNRTRG 97
            |..:|.....|.|..      :||..||...::|........: ||        .||.|
Yeast   839 GDIENNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGLSKSEAIF--------HWRDL------ 889

  Fly    98 LFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLN 162
              |.:..|...::.:|.||.|...||.|.|:||:|||||||||:.||.|...|:   .:|...::
Yeast   890 --CYDVPIKGGQRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGV---ITGNIFVD 949

  Fly   163 GQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKC 227
            |:..| :.......|.||.||.:.:.|.||.|.|.|.:|.|..::..::...|::||:.|.:.:.
Yeast   950 GRLRD-ESFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEMQQY 1013

  Fly   228 QHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLI-CDEPTSGLDSFTAHSVVQVLKKLSQKGK 291
            ...::||.|  :||:..:||||....|....|.||: .|||||||||.||....|:::||:..|:
Yeast  1014 SDAVVGVAG--EGLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRKLATHGQ 1076

  Fly   292 TVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPSEA----VDFFSYVGA-QCPTNYNPADFYV 350
            .::.||||||:.|.:.||::|.:.: |:..:.|...|.    :|:|...|| :||.:.|||::.:
Yeast  1077 AILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWML 1141

  Fly   351 QVLAVVPG-REIESRDRIAKICDNF-AISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQF 413
            :|:...|| ...:..:.:.:..|.: |:.:....||:.|..::.|...|:.:   .:.|:.:.||
Yeast  1142 EVVGAAPGSHATQDYNEVWRNSDEYKAVQEELDWMEKNLPGRSKEPTAEEHK---PFAASLYYQF 1203

  Fly   414 RAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNV 478
            :.|..|.:....:.|..:..:.|.|....:.||..|.....:..|:.|...:||::..      :
Yeast  1204 KMVTIRLFQQYWRSPDYLWSKFILTIFNQVFIGFTFFKADRSLQGLQNQMLSIFMYTV------I 1262

  Fly   479 FATINVFTSELPVFM--------REARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGL 535
            |..|  ....||.|:        ||..||.:....:||.:.|.|:|..:....:...|.|..:|.
Yeast  1263 FNPI--LQQYLPSFVQQRDLYEARERPSRTFSWLAFFLSQIIVEIPWNILAGTIAYCIYYYAVGF 1325

  Fly   536 RA-----------GVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGG 589
            .|           |.|.:...:|....:.    |.|.|:...:.....|..:|..:....|.|.|
Yeast  1326 YANASAAGQLHERGALFWLFSIAFYVYIG----SMGLLMISFNEVAETAAHMGTLLFTMALSFCG 1386

  Fly   590 FFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTS---------SNTTCPSSGKV 645
            .......:|.:..::..:|...|..:.||....|:|   ::.|::         |.|||
Yeast  1387 VMATPKVMPRFWIFMYRVSPLTYMIDALLALGVANV---DVKCSNYEMVKFTPPSGTTC------ 1442

  Fly   646 ILETLNFSAADLPLDYVGLA 665
                     .|....|:.||
Yeast  1443 ---------GDYMASYIKLA 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	170/636 (27%)
PDR15	NP_010694.1	ABC_trans_N	47..162	CDD:464194
		3a01205	110..1518	CDD:273362	179/670 (27%)