DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ADP1

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_009937.2	Gene:	ADP1 / 850369	SGDID:	S000000604	Length:	1049	Species:	Saccharomyces cerevisiae

Alignment Length:	732	Identity:	205/732 - (28%)
Similarity:	341/732 - (46%)	Gaps:	132/732 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GFGQAKNYGTLRPPSPPEDSGSGSGQ-----LA----ENLTYAWHNMDIFGAVNQPGSGWRQLVN 93
            |.|.:|:...|    |.||:.:...|     ||    ||:||:      ..::|..|      |.
Yeast   354 GLGSSKSPIRL----PDEDAVNNFLQNEDDTLATLSFENITYS------VPSINSDG------VE 402

  Fly    94 RTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGM 158
            .|                :|..:.|:..||::||:||.|||||||||:.||.:...|   ..||.
Yeast   403 ET----------------VLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTG---HVSGS 448

  Fly   159 RLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELS 223
            ..:||..:|.|.......:|.|||..:.:||..|.::..|::|:|:.|::..:.|||.:|::||.
Yeast   449 IKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKARVYKVLEELR 513

  Fly   224 LSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQ 288
            :...:..|||.... :|:||||::|::.|.|.:|.|.:|..||||||||:..|::|::.|.:||.
Yeast   514 IIDIKDRIIGNEFD-RGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLSS 577

  Fly   289 K-GKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQV 352
            . .:|::|:||||.|.:|.||||::|:::|.:.:.|...:..:|....|..||.|||.||:.:.:
Yeast   578 DYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNIADYLIDI 642

  Fly   353 L-------------------AVVPGREIES------------------------RDRIA------ 368
            .                   |.....:|::                        ||.|.
Yeast   643 TFEAGPQGKRRRIRNISDLEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHRDEIRSLLRDE 707

  Fly   369 ------------------------KICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATW 409
                                    |..|:...:::::::|::|:..:.|..:...:.....::..
Yeast   708 EDVEGTDGRRGATEIDLNTKLLHDKYKDSVYYAELSQEIEEVLSEGDEESNVLNGDLPTGQQSAG 772

  Fly   410 FMQFRAVL-WRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNM 473
            |:|..::| .||:.::.:.|.|:....:.|.::::.:|.::........|..|..|..|..||..
Yeast   773 FLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVSNDISGFQNRMGLFFFILTYF 837

  Fly   474 TFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAE-LPLFLTVPLVFTAIAYPMIGLRA 537
            .|. .|..::.|..|..:|::|..:..|....|::.|.::| :||.:..|::.:.|.|||.||..
Yeast   838 GFV-TFTGLSSFALERIIFIKERSNNYYSPLAYYISKIMSEVVPLRVVPPILLSLIVYPMTGLNM 901

  Fly   538 GVLHFFNCLALVTLVANVSTSFGYL---ISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVP- 598
            ....||.|:.::.|. |:..|...|   |.....:.|:.|||  .|::..|||.|.|:|:.::.
Yeast   902 KDNAFFKCIGILILF-NLGISLEILTIGIIFEDLNNSIILSV--LVLLGSLLFSGLFINTKNITN 963

  Fly   599 VYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVG 663
            |..|:|...|.|.||.|.||||:...:...|.. ...|...|  |..||.|..|...:|..|...
Yeast   964 VAFKYLKNFSVFYYAYESLLINEVKTLMLKERK-YGLNIEVP--GATILSTFGFVVQNLVFDIKI 1025

  Fly   664 LAILIVSFRVLAYLALR 680
            ||:..|.|.::.||||:
Yeast  1026 LALFNVVFLIMGYLALK 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	193/693 (28%)
ADP1	NP_009937.2	EGF_CA	<70..>90	CDD:419698
ADP1	NP_009937.2	3a01204	402..1042	CDD:273361	187/666 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55852
Inparanoid	1	1.050	280	1.000	Inparanoid score	I560
Isobase	1	0.950	-	0	Normalized mean entropy	S2636
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	1	0.960	-	-
	11	10.700