DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG25

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_565030.1	Gene:	ABCG25 / 843527	AraportID:	AT1G71960	Length:	662	Species:	Arabidopsis thaliana

Alignment Length:	633	Identity:	201/633 - (31%)
Similarity:	307/633 - (48%)	Gaps:	67/633 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 IFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLN 141
            :.|...:|....|....||                :|..|.|:..|||.:||:|.||:||:||||
plant    64 LLGLKQKPSDETRSTEERT----------------ILSGVTGMISPGEFMAVLGPSGSGKSTLLN 112

  Fly   142 ALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHL 206
            |:|.|. .|..:  :|..|:|...: .|:...|..:|.||||....||.||.|:|.|::|:||.|
plant   113 AVAGRL-HGSNL--TGKILINDGKI-TKQTLKRTGFVAQDDLLYPHLTVRETLVFVALLRLPRSL 173

  Fly   207 TYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGL 271
            |...::...:.||.||.|:||::|::| ...::|:|||||||::.|.|.|.:|.||:.|||||||
plant   174 TRDVKLRAAESVISELGLTKCENTVVG-NTFIRGISGGERKRVSIAHELLINPSLLVLDEPTSGL 237

  Fly   272 DSFTAHSVVQVLKKLSQ-KGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYV 335
            |:..|..:||.|..|:. |||||:.:||||||.:|::||.:||::||:..|:|...:|:.:|..|
plant   238 DATAALRLVQTLAGLAHGKGKTVVTSIHQPSSRVFQMFDTVLLLSEGKCLFVGKGRDAMAYFESV 302

  Fly   336 GAQCPTNYNPADFYV-------QVLAVVPGREIESRDRIAKICDNFAISKVARDMEQLLATKNLE 393
            |.......|||||.:       |...|....:...|..:....|.....:|...:|.....::..
plant   303 GFSPAFPMNPADFLLDLANGVCQTDGVTEREKPNVRQTLVTAYDTLLAPQVKTCIEVSHFPQDNA 367

  Fly   394 KPLEQPENG---YTYKATWFMQFRAVLWRSWLSVLKE------PLLVKVRLIQTTMVAILIGLIF 449
            :.::...||   .|..||||.|...:|.|    :|||      .||   |:.|....:||.||::
plant   368 RFVKTRVNGGGITTCIATWFSQLCILLHR----LLKERRHESFDLL---RIFQVVAASILCGLMW 425

  Fly   450 LGQQLTQVGVMNINGAIFLFLTNMTFQNVFATIN-VFT--SELPVFMREARSRLYRCDTYFLGKT 511
            ....     ..:::..:.|......|..|..:.| |||  .|..:|.||..|.:|...:||:...
plant   426 WHSD-----YRDVHDRLGLLFFISIFWGVLPSFNAVFTFPQERAIFTRERASGMYTLSSYFMAHV 485

  Fly   512 IAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSV 576
            :..|.:.|.:|..|....|.|:.||.|::.|...|:::.|....|...|..:..|......|.::
plant   486 LGSLSMELVLPASFLTFTYWMVYLRPGIVPFLLTLSVLLLYVLASQGLGLALGAAIMDAKKASTI 550

  Fly   577 GPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGE-----ISCTSSN 636
            ....::.|:|.||:::|  .||..:.|:.|:|...|....|:..|:..   ||     :.|.|..
plant   551 VTVTMLAFVLTGGYYVN--KVPSGMVWMKYVSTTFYCYRLLVAIQYGS---GEEILRMLGCDSKG 610

  Fly   637 ----TTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALR 680
                :...|:|...:|........:......|.::...:|||||||||
plant   611 KQGASAATSAGCRFVEEEVIGDVGMWTSVGVLFLMFFGYRVLAYLALR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	201/633 (32%)
ABCG25	NP_565030.1	PLN03211	1..662	CDD:215634	201/633 (32%)
		ABCG_EPDR	70..290	CDD:213180	102/240 (43%)
		ABC2_membrane	393..592	CDD:279410	56/212 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm2959
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.680