DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG39

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_176867.2	Gene:	ABCG39 / 843013	AraportID:	AT1G66950	Length:	1454	Species:	Arabidopsis thaliana

Alignment Length:	693	Identity:	189/693 - (27%)
Similarity:	322/693 - (46%)	Gaps:	109/693 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLTYAWHNMDIFGAVNQPGSG 87
            |.|..|:..:  :|....:....|.:.|..|              |:.|::|::.:  |:.|..
plant   822 NRGTEGSVVE--LNSSSNKGPKRGMVLPFQP--------------LSLAFNNVNYY--VDMPSE- 867

  Fly    88 WRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQG-I 151
                 .:.:|       :...|..||::|.|...||.|.|::|.||||||||::.||.|...| |
plant   868 -----MKAQG-------VEGDRLQLLRDVGGAFRPGILTALVGVSGAGKTTLMDVLAGRKTGGYI 920

  Fly   152 QVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVD 216
            :.|.|    ::|.|.:.........|.:|:|:....:|..|.||:.|.:|:...:..:.|...|:
plant   921 EGSIS----ISGYPKNQTTFARVSGYCEQNDIHSPHVTVYESLIYSAWLRLSTDIDIKTRELFVE 981

  Fly   217 QVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQ 281
            :|::.:.|...:::|:|:|| |.|||..:||||..|.|.:.:|.::..||||||||:..|..|::
plant   982 EVMELVELKPLRNSIVGLPG-VDGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMR 1045

  Fly   282 VLKKLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGT----PSEAVDFFSYVGAQCPT 341
            .::.....|:||:.||||||.::||.||::|||.. |:|.:.|:    ..:.|::|..|......
plant  1046 TVRNTVDTGRTVVCTIHQPSIDIFESFDELLLMKRGGQVIYAGSLGHHSQKLVEYFEAVEGVPKI 1110

  Fly   342 N--YNPADFYVQVLAVVPGREIESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGY- 403
            |  ||||.:.:.|  ..|..|.:.....|:|   |:.|.:.|..::|:  |:|..|....::.|
plant  1111 NDGYNPATWMLDV--TTPSMESQMSLDFAQI---FSNSSLYRRNQELI--KDLSTPPPGSKDVYF 1168

  Fly   404 --TYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVG-------- 458
              .|..::..|.:|..|:.:.|..:.|....:|.:.|.::.:|.||||     .|:|
plant  1169 KTKYAQSFSTQTKACFWKQYWSYWRHPQYNAIRFLMTVVIGVLFGLIF-----WQIGTKTENEQD 1228

  Fly   459 VMNINGAIF---LFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLT 520
            :.|..||::   |||..:....|...|.:   |..||.||..:.:|....|.:.:...|: ::.|
plant  1229 LNNFFGAMYAAVLFLGALNAATVQPAIAI---ERTVFYREKAAGMYSAIPYAISQVAVEI-MYNT 1289

  Fly   521 VPL-VFTAIAYPMIGLRAGVLHF--FNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVII 582
            :.. |:|.|.|.|||....:..|  |....|.:.:  ..|.:|.::...:.:..:|     .:.:
plant  1290 IQTGVYTLILYSMIGCNWTMAKFLWFYYYMLTSFI--YFTLYGMMLMALTPNYQIA-----GICM 1347

  Fly   583 PFL-----LFGGFFLNSGSVPVYLKWLSY---LSWFRYANEGLLINQWADVEPGEISCTSSNTTC 639
            .|.     ||.||.:....:|::.:|..:   ::|..|   ||:.:|..|.:        |....
plant  1348 SFFLSLWNLFSGFLIPRPQIPIWWRWYYWATPVAWTLY---GLITSQVGDKD--------SMVHI 1401

  Fly   640 PSSGKVILETL-----NFSAADLP-LDYVGLAILIVSFRVLAY 676
            ...|.:.|:||     .|....|| :..|.:|.:::...|.||
plant  1402 SGIGDIDLKTLLKEGFGFEHDFLPVVAVVHIAWILLFLFVFAY 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	182/648 (28%)
ABCG39	NP_176867.2	PLN03140	14..1454	CDD:215599	189/693 (27%)
		ABC_trans_N	94..169	CDD:291196
		P-loop_NTPase	180..430	CDD:304359
		ABC2_membrane	531..737	CDD:279410
		PDR_assoc	744..810	CDD:285559
		ABCG_PDR_domain2	850..1088	CDD:213199	90/271 (33%)
		ABC2_membrane	1183..1388	CDD:279410	52/223 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870