DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG8

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_200098.1	Gene:	ABCG8 / 835363	AraportID:	AT5G52860	Length:	589	Species:	Arabidopsis thaliana

Alignment Length:	647	Identity:	172/647 - (26%)
Similarity:	301/647 - (46%)	Gaps:	81/647 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PPSPPEDSGSGSGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPA--PRKHL 112
            |||||.::.      |..||.:..:..|      |.:....|            ..||  |...:
plant     4 PPSPPPETA------AYTLTTSSISYTI------PKTSLSLL------------RFPATEPPSFI 44

  Fly   113 LKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSP-SGMRLLNGQPVDAKEMQARCA 176
            |:|:...|:|.|:|||:|.|||||:|||:.||.::      || ||..|||..|::....:...:
plant    45 LRNITLTAHPTEILAVVGPSGAGKSTLLDILASKT------SPTSGSILLNSIPINPSSYRKISS 103

  Fly   177 YVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGL 241
            ||.|.|.|...||..|...|.|.:.:|......:.|.   .::.||:|:...||.:     .:||
plant   104 YVPQHDSFFPLLTVSETFSFAACLLLPNPSIVSETVT---SLLSELNLTHLSHTRL-----AQGL 160

  Fly   242 SGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLS-QKGKTVILTIHQPSSELF 305
            |||||:|::.....|.||..|:.|||||||||.:|..|:.:||.:: .:.:||||:|||||.::.
plant   161 SGGERRRVSIGLSLLHDPCFLLLDEPTSGLDSKSAFDVIHILKSIAVSRQRTVILSIHQPSFKIL 225

  Fly   306 ELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAKI 370
            .:.|::||:::|.|.:.|.......|..:.|...|...|..::.:::|     :|:...|.
plant   226 SIIDRLLLLSKGTVVYHGRLDSLEGFLLFKGFTVPPQLNSLEYAMEIL-----QELRESDG---- 281

  Fly   371 CDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRL 435
                     ..|...|.:.:|.::  .:.::...|:.:...:...:..|.|..:.:...|:....
plant   282 ---------NTDATALPSIENRKQ--REKQSIVRYRKSRITEISLLARRFWKIIYRTRQLLLTNA 335

  Fly   436 IQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRL 500
            ::..:|.:::|.|::...:.:.|:....| :|.|.......:...|:.:|.:|.|:.:||..|.:
plant   336 LEALVVGLVLGTIYINIGIGKAGIEKRFG-MFAFTLTFLLSSTTETLPIFINERPILLRETSSGI 399

  Fly   501 YRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYLISC 565
            ||..::.|..|:..||....:.::::...|.:|||......|...:.::.::..::.||...:|.
plant   400 YRLSSHILANTLVFLPYLFVISIIYSVSVYFLIGLCPTWQAFGYFVLVIWIILLMANSFVLFLSS 464

  Fly   566 ASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEI 630
            .:.:.....|:...::..|.||.|:|::..|:|.|..::.:.|.::||.:.||||        |.
plant   465 LAPNYITGTSLVTILLAAFFLFSGYFISKESLPKYWLFMYFFSMYKYALDALLIN--------EY 521

  Fly   631 SCTSS----------NTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLR 682
            ||.:|          ...|..:|..:|:...........:...|....|.:|||.:|||..|
plant   522 SCLASKCLVWLEEAQTKICMVTGGDVLKKKGLHEKQRWFNVYVLLGFFVLYRVLCFLALLRR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	166/629 (26%)
ABCG8	NP_200098.1	P-loop_NTPase	29..243	CDD:304359	87/239 (36%)
		3a01204	44..584	CDD:273361	158/583 (27%)
		ABC2_membrane	316..519	CDD:279410	45/203 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880