DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG4

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_194305.1	Gene:	ABCG4 / 828680	AraportID:	AT4G25750	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	586	Identity:	165/586 - (28%)
Similarity:	290/586 - (49%)	Gaps:	59/586 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSP-SGMRLLNGQPVDAKEMQARC 175
            :|:|:...::|.::||::|.|||||:|||:.||.|:      || ||..|||...::....:...
plant    30 ILRNITLTSHPSQILAIIGPSGAGKSTLLDILAART------SPTSGSILLNSVLINPSSYRKIS 88

  Fly   176 AYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKG 240
            :||.|.|.|...||..|...|.|.:.:|::|:....|  |..:::||:|:...||.:|     :|
plant    89 SYVPQHDTFFPLLTVSETFTFSASLLLPKNLSKVSSV--VASLLKELNLTHLAHTRLG-----QG 146

  Fly   241 LSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKL-SQKGKTVILTIHQPSSEL 304
            ||||||:|::.....|.||.:|:.|||||||||.:|..|||:||.: :.:.:.|||:|||||.::
plant   147 LSGGERRRVSIGLSLLHDPEVLLLDEPTSGLDSKSAFDVVQILKSIATSRERIVILSIHQPSFKI 211

  Fly   305 FELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAK 369
            ..|.|::||:::|.:.:.|.......|....|...|:..|..::.:::|..:  |:......||
plant   212 LSLIDRVLLLSKGTIVYHGRLDLLEAFLLSKGFTVPSQLNSLEYAMEILQNI--RDPYENANIA- 273

  Fly   370 ICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVR 434
            :.|:...||.....:.::                .||::...:...:..|.|..:.:...|:...
plant   274 LPDHCPESKKQNQKQSIV----------------RYKSSRITEISLLSSRFWKIIYRTRQLLLTN 322

  Fly   435 LIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSR 499
            ::::.:|.:::|.|:|.....:.|:....| :|.|.......:...|:.:|..|.|:.:||..|.
plant   323 ILESLVVGLVLGTIYLNIGTGKEGIRKRFG-LFAFTLTFLLSSTTQTLPIFIDERPILLRETSSG 386

  Fly   500 LYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGL---RAGVLHFFNCLALVTLVANVSTSFGY 561
            |||..::.|..|:..||..|.:.::::...|.::||   ...:.:|...:.::.|:||   ||..
plant   387 LYRLSSHILANTLVFLPYLLLIAIIYSVSLYFLVGLCFSWQALAYFVLVIWIIVLMAN---SFVL 448

  Fly   562 LISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVE 626
            .:|..:.:.....|....::..|.||.|:|::..|:|.|..::.:.|.::||.:.||||
plant   449 FLSSLAPNYIAGTSSVTILLAAFFLFSGYFISKESLPKYWLFMYFFSMYKYALDALLIN------ 507

  Fly   627 PGEISC----------TSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRL 681
              |.||          .:|..:|..:|..:|:...........:...|....|.:|||.:|.|..
plant   508 --EYSCLHNKCLVWFEEASVNSCLVTGGDVLDKNGLHERQRWFNVYMLLGFFVLYRVLCFLVLLK 570

  Fly   682 R 682
            |
plant   571 R 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	165/586 (28%)
ABCG4	NP_194305.1	3a01204	30..572	CDD:273361	165/586 (28%)
		P-loop_NTPase	30..230	CDD:304359	84/212 (40%)
		ABC2_membrane	304..507	CDD:279410	50/206 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880