DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG7

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_849922.1	Gene:	ABCG7 / 814660	AraportID:	AT2G01320	Length:	728	Species:	Arabidopsis thaliana

Alignment Length:	616	Identity:	195/616 - (31%)
Similarity:	319/616 - (51%)	Gaps:	43/616 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GSGWRQLVNRTRGLFC--NERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRS 147
            |...|.:..|.|.:.|  :::...:.| .|||||.|.|.||.|||:||.||:|||||||.||.:
plant    62 GDSIRPVTIRWRNITCSLSDKSSKSVR-FLLKNVSGEAKPGRLLAIMGPSGSGKTTLLNVLAGQ- 124

  Fly   148 PQGIQVSP----SGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTY 208
               :.:||    ||:..:||:|..:|..  :.|:|:|:|||...||.||.|.|.|.:::|...:.
plant   125 ---LSLSPRLHLSGLLEVNGKPSSSKAY--KLAFVRQEDLFFSQLTVRETLSFAAELQLPEISSA 184

  Fly   209 RQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDS 273
            .:|...|:.::.:|.|..|..:.:| ..:|:|:||||:|||:.|.|.:..|.::..||||:|||:
plant   185 EERDEYVNNLLLKLGLVSCADSCVG-DAKVRGISGGEKKRLSLACELIASPSVIFADEPTTGLDA 248

  Fly   274 FTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLG-TPSEAVDFFSYVGA 337
            |.|..|::.|:||:|.|.|||.:||||...::..||.|:|:.||.:.:.| ...|.:.:|...|.
plant   249 FQAEKVMETLQKLAQDGHTVICSIHQPRGSVYAKFDDIVLLTEGTLVYAGPAGKEPLTYFGNFGF 313

  Fly   338 QCPTNYNPADFYVQVLAVVPGRE---IESRDRIAKICDNFAISKVARDMEQLLATKNLEKPL--- 396
            .||.:.|||:|...:::|.....   ..|:.|:..:.|.|:    .|....|.||     ||
plant   314 LCPEHVNPAEFLADLISVDYSSSETVYSSQKRVHALVDAFS----QRSSSVLYAT-----PLSMK 369

  Fly   397 EQPENGYTYKAT--------WFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQ 453
            |:.:||...:..        |:.||..:|.|:|:...::....|||...:...|::.|.:|....
plant   370 EETKNGMRPRRKAIVERTDGWWRQFFLLLKRAWMQASRDGPTNKVRARMSVASAVIFGSVFWRMG 434

  Fly   454 LTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLF 518
            .:|..:.:..|.:.:...|.....:..|:.||..|..:..||.....|....|.|.|||||:|:.
plant   435 KSQTSIQDRMGLLQVAAINTAMAALTKTVGVFPKERAIVDRERSKGSYSLGPYLLSKTIAEIPIG 499

  Fly   519 LTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIP 583
            ...||:|.|:.|||..|...:..|.....:||:.:..:::.|..:.....||..|::|||.::..
plant   500 AAFPLMFGAVLYPMARLNPTLSRFGKFCGIVTVESFAASAMGLTVGAMVPSTEAAMAVGPSLMTV 564

  Fly   584 FLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILE 648
            |::|||:::|:.:.|:..:|:...|..|:|.:||.||:::.     :.....||....:|:..||
plant   565 FIVFGGYYVNADNTPIIFRWIPRASLIRWAFQGLCINEFSG-----LKFDHQNTFDVQTGEQALE 624

  Fly   649 TLNFSAADLPLDYVGLAILIVSFRVLAYLAL 679
            .|:|....:.......:.:::.:....||.|
plant   625 RLSFGGRRIRETIAAQSRILMFWYSATYLLL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	195/616 (32%)
ABCG7	NP_849922.1	ABCG_EPDR	67..298	CDD:213180	97/238 (41%)
		3a01204	90..655	CDD:273361	188/585 (32%)
		ABC2_membrane	397..601	CDD:279410	57/203 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1972
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm1120
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730