DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and abcg2a

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_021325521.1	Gene:	abcg2a / 735312	ZFINID:	ZDB-GENE-050517-35	Length:	644	Species:	Danio rerio

Alignment Length:	653	Identity:	199/653 - (30%)
Similarity:	350/653 - (53%)	Gaps:	61/653 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DSGSGSGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVA 120
            ::|..|.......|.::||:: :....:.|             ||..:   :.:|::|..:.|:.
Zfish    19 NTGVSSSPSRRGATVSFHNIN-YSLKMKSG-------------FCKSK---STKKNILIGLNGIM 66

  Fly   121 YPGELLAVMGSSGAGKTTLLNALAFR-SPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLF 184
            .|| |.|::|::|:||::.|:.||.| .|.|:    ||..|::|.| .....:....||.|||:.
Zfish    67 KPG-LNAILGATGSGKSSFLDVLAARKDPAGL----SGEVLIDGAP-QPPNFKCLSGYVVQDDVV 125

  Fly   185 IGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRL 249
            :|:||.||:|.|.|.:|:|:.:..|::..:|:::||||.|||...:.:|.. .::|:|||||||.
Zfish   126 MGTLTVRENLRFSAALRLPKSIKQREKDEKVERLIQELGLSKVADSRVGTQ-LIRGVSGGERKRT 189

  Fly   250 AFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLM 314
            ....|.:.|||:|..||||:|||:.||:||:.:|||:...|:|:||:||||...::.|||.:.|:
Zfish   190 NIGMELIIDPPVLFLDEPTTGLDASTANSVLMLLKKMGNNGRTIILSIHQPRYSIYRLFDSLTLL 254

  Fly   315 AEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVL-----AVVPGR---EIESRDRIA--- 368
            ..|::.:.|...:|:.:||.:|..|..:.|||||::.|:     ||...:   |:..:|:::
Zfish   255 VGGKLVYHGPAQDALSYFSQIGYTCEPHNNPADFFLDVINGDSSAVTLNKLYEEVVDQDQLSSSL 319

  Fly   369 -----KICDNFAISKVAR----DMEQLLATKNLEKPLEQPEN-GYTYKATWFMQFRAVLWRSWLS 423
                 ::.:.:..|.:.:    |:::::..::..   .:|:: ..||..::..||..||.|::.:
Zfish   320 KGIEDRLVEEYQRSSIFQQTHADLQRIVQGQDYS---TRPKSRTITYSTSFCHQFHWVLKRTFRN 381

  Fly   424 VLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSE 488
            ::..|.....::.....:|:::|.||.|......|:.|..||:|...||..|.:|.|. .:|.:|
Zfish   382 LMLNPQTSVAQIGVMIFLALVVGAIFFGVAENSSGIQNRMGALFFITTNQCFSSVSAA-ELFIAE 445

  Fly   489 LPVFMREARSRLYRCDTYFLGKTIAELPLFLTVP-LVFTAIAYPMIGLRAGVLHFFNCLALVTLV 552
            ..:|:.|..|..||...|||.|.::::....|:| ::|:.:||.||||:.....||..|..:.:|
Zfish   446 RKLFVHEYISGYYRVSVYFLSKILSDILTLRTIPAVIFSCVAYFMIGLKPAAEAFFIFLFSIIMV 510

  Fly   553 ANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGL 617
            :..:|:....||...:..::|........:..::|.|..:|..||..:|.||.|.|..||....|
Zfish   511 SYTATAMTLAISADQTVVAIANIFMTISFVFMMIFSGLLVNLPSVATWLNWLKYFSIPRYGLSAL 575

  Fly   618 LINQWADVEPGEISC---TSSNTTCPSSGKVILET--LNFSAADLPLDYVGLAILIVSFRVLAYL 677
            .||::.    |...|   .:|.:.| |||:..|:.  :::||..|..:::.|.|:...|..:|||
Zfish   576 QINEFT----GLFFCDNRNNSGSVC-SSGEEFLQEQGIDYSAWGLWQNHLALGIMTFIFLCIAYL 635

  Fly   678 ALR 680
            .||
Zfish   636 KLR 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	197/641 (31%)
abcg2a	XP_021325521.1	PRK10535	43..638	CDD:333000	192/626 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55852
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm6474
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750