Protein Alignment w and Abcg8

DIOPT Version :9

• Sequence 1: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_080456.1
• Gene: Abcg8 / 67470
• MGIID: 1914720
• Length: 673
• Species: Mus musculus
• Alignment Length: 608
• Identity: 179/608 - (29%)
• Similarity: 291/608 - (47%)
• Gaps: 71/608 - (11%)

  Fly   113 LKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAY 177
            ::|:......|::||::||||.|:.:||:.:..|...|  ...||...:||||...:.::...|:
Mouse    89 IRNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGG--KMKSGQIWINGQPSTPQLVRKCVAH 151

  Fly   178 VQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLS 242
            |:|.|..:.:||.||.|.|.|.:|:||..:..||..||:.||.||.|.:|.:|.:| ...|:|:|
Mouse   152 VRQHDQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCANTRVG-NTYVRGVS 215

  Fly   243 GGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFEL 307
            ||||:|::...:.|.:|.:||.|||||||||||||::|..|.:|::..:.|::::|||.|::|.|
Mouse   216 GGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLAKGNRLVLISLHQPRSDIFRL 280

  Fly   308 FDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAKICD 372
            ||.:|||..|...:||...:.|.:|:.:|..||...|||||||         ::.|.||.:|..:
Mouse   281 FDLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYV---------DLTSIDRRSKERE 336

  Fly   373 NFAISKVARDMEQLLATKNLEKPLEQPENGYTYKAT----------------------------- 408
            ...:.|.     |.||...|||  .|..:.:.:||.
Mouse   337 VATVEKA-----QSLAALFLEK--VQGFDDFLWKAEAKELNTSTHTVSLTLTQDTDCGTAVELPG 394

  Fly   409 WFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNM 473
            ...||..::.|...:..::...:.:...:..:::::||.::.|....|:..|:....:|:....:
Mouse   395 MIEQFSTLIRRQISNDFRDLPTLLIHGSEACLMSLIIGFLYYGHGAKQLSFMDTAALLFMIGALI 459

  Fly   474 TFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLR-- 536
            .|..:...::...||..:...|....||....||..|.:.|||......:::....|.:..||
Mouse   460 PFNVILDVVSKCHSERSMLYYELEDGLYTAGPYFFAKILGELPEHCAYVIIYAMPIYWLTNLRPV 524

  Fly   537 --AGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPV 599
              ..:|||.    ||.||.....:.....|....:..|:......:...|.|..||.:|..::.:
Mouse   525 PELFLLHFL----LVWLVVFCCRTMALAASAMLPTFHMSSFFCNALYNSFYLTAGFMINLDNLWI 585

  Fly   600 YLKWLSYLSWFRYANEGLLINQWADVEPGEISCTS-SNTTCPSSGKVILETLNFSAADL---PLD 660
            ...|:|.||:.|:...||:..|:    .|.:..|. .|.|....|..::     ||.||   ||.
Mouse   586 VPAWISKLSFLRWCFSGLMQIQF----NGHLYTTQIGNFTFSILGDTMI-----SAMDLNSHPLY 641

  Fly   661 YVGLAILIVS--FRVLAYLALRL 681
            .:.|.::.:|  |..|.||:|:|
Mouse   642 AIYLIVIGISYGFLFLYYLSLKL 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	179/608 (29%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	86/209 (41%)
		3a01204	89..664	CDD:273361	178/606 (29%)
		ABC2_membrane	402..606	CDD:279410	43/207 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831363
Domainoid	1	1.000	90	1.000	Domainoid score	I7740
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650