DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and ABCG8

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_011531331.1	Gene:	ABCG8 / 64241	HGNCID:	13887	Length:	677	Species:	Homo sapiens

Alignment Length:	599	Identity:	180/599 - (30%)
Similarity:	294/599 - (49%)	Gaps:	54/599 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAY 177
            ::|:......|::||::||||.|:.:||:.:..|...|  ...||...:||||...:.::...|:
Human    92 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGG--KIKSGQIWINGQPSSPQLVRKCVAH 154

  Fly   178 VQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLS 242
            |:|.:..:.:||.||.|.|.|.:|:||..:..||..||:.||.||.|.:|..|.:| ...|:|||
Human   155 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVG-NMYVRGLS 218

  Fly   243 GGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFEL 307
            ||||:|::...:.|.:|.:||.|||||||||||||::|:.|.:|::..:.|::::|||.|::|.|
Human   219 GGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRL 283

  Fly   308 FDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAV---VPGREIESRDRIAK 369
            ||.:|||..|...:||.....|.:|:.:|..||...|||||||.:.::   ...:|:.:|::...
Human   284 FDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQS 348

  Fly   370 ICDNFAISKVARDMEQLL---ATKNLEK---------PLE-----QPENGYTYKATWFMQFRAVL 417
            :...| :.|| ||::..|   .||:|::         ||:     .|    |.......||..::
Human   349 LAALF-LEKV-RDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSP----TKMPGAVQQFTTLI 407

  Fly   418 WRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATI 482
            .|...:..::...:.:...:..::::.||.::.|....|:..|:....:|:....:.|..:...|
Human   408 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVI 472

  Fly   483 NVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAG----VLHF- 542
            :...||..:...|....||....||..|.:.|||......:::....|.:..||.|    :|||
Human   473 SKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFL 537

  Fly   543 ------FNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYL 601
                  |.|..:....|.:..:|           .||......:...|.|.|||.:|..|:....
Human   538 LVWLVVFCCRIMALAAAALLPTF-----------HMASFFSNALYNSFYLAGGFMINLSSLWTVP 591

  Fly   602 KWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAI 666
            .|:|.:|:.|:..|||:..|::   .........|.|...||..||..:...:..|...|:.:..
Human   592 AWISKVSFLRWCFEGLMKIQFS---RRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIG 653

  Fly   667 LIVSFRVLAYLALR 680
            |...|.||.|::||
Human   654 LSGGFMVLYYVSLR 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	180/599 (30%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	86/209 (41%)
		3a01204	92..667	CDD:273361	178/597 (30%)
		ABC2_membrane	406..610	CDD:279410	47/214 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141422
Domainoid	1	1.000	98	1.000	Domainoid score	I7174
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.650