DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and abcg2b

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001034155.1	Gene:	abcg2b / 570453	ZFINID:	ZDB-GENE-050517-36	Length:	618	Species:	Danio rerio

Alignment Length:	604	Identity:	206/604 - (34%)
Similarity:	330/604 - (54%)	Gaps:	43/604 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFR-SPQGIQVSP 155
            :..:|||.|.:    ||.:.:||||.|:...| |.|:||::|:|||:||:.:|.| .|:|::
Zfish    37 IRESRGLCCKK----APERDILKNVSGIMKTG-LNAIMGATGSGKTSLLDVMAGRKDPRGLR--- 93

  Fly   156 SGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPR-HLTYRQRVARVDQVI 219
            ||..|::.:.| ..:::...|||.|||:.:|:||.||:|:|...:|:|| ..:...:..:|:.:|
Zfish    94 SGQVLVDNKLV-TSDLRLMSAYVVQDDVLMGTLTVRENLLFSGNLRLPREQFSSADKKKKVESII 157

  Fly   220 QELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLK 284
            :||.|..|..|.||.. .::|:|||||||.:...|.:|.|.||..||||:||||.||:|::.:|.
Zfish   158 EELGLEDCADTKIGTE-FIRGVSGGERKRCSIGMELITSPTLLFLDEPTTGLDSNTANSIIALLH 221

  Fly   285 KLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFY 349
            :||:.|:|:|.:||||...:|.|||.:.||.:|...:.|...:|:|:|..:|.:.....|||||:
Zfish   222 RLSRGGRTIIFSIHQPRYSIFRLFDYLTLMHKGETVYAGPAGKAIDYFQSLGYERDAFNNPADFF 286

  Fly   350 VQVLAVVPGREIESRDRIAKICDNFAISK--VARDMEQLLATKNLEKPLEQPENGYTYKATWFMQ 412
               |.:..|....|......:.:.:..|:  .|.|.|....|...:...|......:|..::..|
Zfish   287 ---LDITNGETATSMPTEKSLAELYRESQFCTAVDEELKCITGPSDSLSEAKSKAPSYVTSFSYQ 348

  Fly   413 FRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLT-QVGVMNINGAIFLFLTNMTFQ 476
            .:.|.||:.|:|::.|.....::....:.|:||||::....|| ...:.|..||.|..:.||.|.
Zfish   349 LKVVCWRTGLNVVRNPQTSYAQIAMNILFALLIGLVYYQMPLTLPEALQNRIGAFFFLIINMVFG 413

  Fly   477 NVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVP-LVFTAIAYPMIGLRAGVL 540
            |:.| :.:|.:|..:|:.|.....||...|||.|...:|.....|| |:|::|:|.|:||.....
Zfish   414 NLSA-VELFINERAIFVHENSGGYYRTSVYFLSKVFVDLLPNRIVPILIFSSISYYMMGLNPAFT 477

  Fly   541 HFFNCLAL-VTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPF---LLFGGFFLNSGSVPVYL 601
            .|. |.|| |:||:....|..:|:|.:.|:.:||..:   |::||   ::||||.:|..|:   |
Zfish   478 SFL-CFALTVSLVSLAGVSLAFLVSASVSTFAMANIL---VVLPFVFMMVFGGFLVNLNSM---L 535

  Fly   602 KWLSYLSW---FRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILET--LNFSAADLPLDY 661
            .|||:|.|   |:|..:.:.||     |...:...|.|.|.|  |::.||:  :::|......:.
Zfish   536 NWLSWLKWTSIFKYGLDAVTIN-----EMKGLVLYSGNATLP--GELYLESQGIDYSVWGFWQNE 593

  Fly   662 VGLAILIVSFRVLAYLALR 680
            |.|..:::.....||:.||
Zfish   594 VALLGIVLVCMTFAYIQLR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	206/604 (34%)
abcg2b	NP_001034155.1	P-loop_NTPase	39..260	CDD:304359	96/230 (42%)
		3a01204	41..616	CDD:273361	206/600 (34%)
		ABC2_membrane	354..557	CDD:279410	71/210 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm6474
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750