DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and abca3b

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	627	Identity:	143/627 - (22%)
Similarity:	250/627 - (39%)	Gaps:	134/627 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 YPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPV--DAKEMQARCAYVQQDDL 183
            :.|::..::|.:||||||.|:.|.     |:....||...:||..:  |...::.......|.|:
Zfish   555 FEGQITVLLGHNGAGKTTTLSMLT-----GLFPPSSGRAYINGYDICQDMALIRRSLGLCPQHDV 614

  Fly   184 FIGSLTAREHLIFQAMVR-MPRHLTYRQRV-ARVDQVIQELSL-----SKCQHTIIGVPGRVKGL 241
            ...:||.||||:|...:: .|     |::: ..||::|:.|:|     :||           |.|
Zfish   615 LFDNLTVREHLLFYTQLKGYP-----REKIPGEVDRIIRILNLEDKRNAKC-----------KTL 663

  Fly   242 SGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIH-QPSSELF 305
            |||.:::|:.....:.|..:::.||||||:|.....:...:|:. .::|:|::||.| ...::|
Zfish   664 SGGMKRKLSIGIALIGDSKVVMLDEPTSGMDPSARRATWDLLQG-EKRGRTILLTTHFMDEADL- 726

  Fly   306 ELFDKILLMAEGRVAFLGTP-------SEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIES 363
             |.|:|.:||.|.:...|:|       ...........|.|    |.::....|...||...:||
Zfish   727 -LGDRIAIMASGELQCCGSPLFLKNKYGAGYHMVIVKDAFC----NVSEITRLVHMYVPDATLES 786

  Fly   364 RDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGY-TYKATWFMQFRAVLWRSWLSVLKE 427
             ...|::  ::.:.|.:....:||..   |..:.:.|.|. :|.|:             ::.::|
Zfish   787 -SAGAEL--SYILPKESTSRFELLFA---ELEMNRDELGIASYGAS-------------VTTMEE 832

  Fly   428 PLLVKVRLIQTTMVAILIGLIFLGQQ-------LTQVGVMNINGAIFLFLTNMT-FQNVFATINV 484
            ..|...:|:.:::....|.|..|..|       .|.....:|:|     :|::| |.:....|:.
Zfish   833 VFLRVGKLVDSSLDIQAIQLPALQYQHERRSHDWTMDDSSSISG-----MTDVTDFTDSCTMISE 892

  Fly   485 FTSELPVFMREARSRLYRCDTY--FLGKTI-------AELPLFLTVPLVFTAIA----------Y 530
            ..|.:.:   ...:|||....|  ||.:.:       ..:..|| |||:||.:|          :
Zfish   893 DGSNIKL---NTGARLYMQQFYAMFLKRALYSWRNWKVMVAQFL-VPLIFTVLALVVARSLPSSH 953

  Fly   531 PMIGLRAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPF---LLFG---- 588
            ....||..:..:......|.:.||.......|....::......::..|.|..|   :|:.
Zfish   954 SSPQLRLALKQYGQTHVPVAVEANAGPLASLLAEIYTTQLPSQNAIAAPNITDFSEYVLYNAQRE 1018

  Fly   589 --------------------GFFLNSG-SVPVYLKWLSYLSWFR-YANEGLLINQWADVEPGEIS 631
                                |:|.|.| ..|.....|...:.|: .|.....|....|..|..:|
Zfish  1019 GGAFNEHCVVGAAFRSSDVIGYFNNQGYHTPATALMLVDNALFKLLAGPNASIQTGNDPMPRNVS 1083

  Fly   632 CTSSNTTCPS-SGKVILETLNFSAADLPLDYVGLAILIVSFR 672
            .|:.:....| :|..|...|.:..|.|...:   |:|:||.|
Zfish  1084 ETAQSQLSESQTGFAIAINLMYGMASLASTF---ALLLVSER 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	143/627 (23%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	143/627 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000