DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and abcg5

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001122162.1	Gene:	abcg5 / 557317	ZFINID:	ZDB-GENE-050517-40	Length:	652	Species:	Danio rerio

Alignment Length:	696	Identity:	190/696 - (27%)
Similarity:	334/696 - (47%)	Gaps:	109/696 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 INQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLTYA-------WHNMDIFGAVNQPGSGW-RQL 91
            :|..|.......|.|  |.|:.....|....:|::|:       |.::..|      ...| ||:
Zfish    16 LNGSFKVVSEMETAR--SNPDYIEPSSCLSVKNVSYSVSERVGPWWDLSSF------RKKWTRQI 72

  Fly    92 VNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPS 156
            :|..      ..|:.:               |:::.::|:||:||||||:|:|.|.  |...:..
Zfish    73 LNEV------SFHLDS---------------GQIMGILGNSGSGKTTLLDAIAGRI--GNSGNLQ 114

  Fly   157 GMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQE 221
            |...:||:.:..::.|...:||.|.|..:..||..|.|.:.|.:.:.:|.....| .:|..|:.|
Zfish   115 GEVFVNGRKLKREQFQDCFSYVLQSDNLLSYLTVEETLTYTAQLALRKHSAEAIR-KKVTAVMAE 178

  Fly   222 LSLSKCQHTIIGVPGRV-KGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKK 285
            |||....|::||  ||| .|:|||||:|::.||:.|.||.:::.||||:||||.||:.:|.:|.:
Zfish   179 LSLGHVAHSVIG--GRVFPGISGGERRRVSIASQLLQDPKVILLDEPTTGLDSMTANQIVMLLAE 241

  Fly   286 LSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYV 350
            |:::.:.||:|||||.||||.:|::|.:|::|.:.|.|.|.:.|||||..|.:||...||.|.||
Zfish   242 LARRDRIVIVTIHQPRSELFRIFNRIAIMSQGELVFCGEPHKMVDFFSSCGYECPEYCNPFDIYV 306

  Fly   351 QVLAV---VPGREIESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENG-YTYKA---- 407
            .:.:|   ...||..:..|:..|...:..|::..:|::     .:|:..::|:.. ..:|:
Zfish   307 DLTSVDTRCSEREAATYRRMHDITSAYQNSEIYTNMQE-----KIEQSCQRPDKPMIPFKSKESP 366

  Fly   408 TWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIG--LIFLGQQLTQVGVMNINGAIFLFL 470
            ....:...:|.|::.:|.::.:.:.:||.|..:..:.|.  |:.||:.:|:..|.:..|.|:..:
Zfish   367 NCISKLGVLLRRTFRNVSRDRMGILMRLSQNLIYGLFIAFFLMRLGKDVTKGAVQDRIGLIYQSM 431

  Fly   471 TNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGL 535
            ....:..:...:.:|.:...:..:|::..||:....||...|..||..:....:|.:..|..:|:
Zfish   432 GASPYTGMLNAVALFPALRAISDQESKDGLYQKWQMFLAYIIHILPFSIISVFIFASFLYWTVGM 496

  Fly   536 RAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSV--GPPVI---IPFLLFGGFFLNSG 595
            ....:.|. |.:.|.:|.::   .|.|:      |.:.|.|  .|.::   :..|...|..:.||
Zfish   497 NPDPVRFL-CFSAVVMVPHI---IGELL------TLVLLGVVQDPNMVNSGVALLNIAGIMVGSG 551

  Fly   596 ------SVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCP-----------SSG 643
                  .:||..:|||||::.:|..|.|::.::..:          |.||.           .||
Zfish   552 FLRGFKQMPVVFQWLSYLTFQKYGCELLIVTEFYGL----------NFTCTPIAGLPGECLVDSG 606

  Fly   644 KVILE-----TLNFSAADLPLDYVGLAIL----IVSFRVLAYLALR 680
            .:|::     .|:....|..|.|..|..|    |:||::..:|..|
Zfish   607 NMIIDQGYPGALSRYTQDFLLLYAFLPALVILGIISFKIRDHLVRR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	182/663 (27%)
abcg5	NP_001122162.1	3a01204	50..645	CDD:273361	179/651 (27%)
		ABCG_White	53..279	CDD:213201	89/257 (35%)
		ABC2_membrane	375..582	CDD:279410	50/216 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7419
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920